Analysis of tumor-infiltrating CD103 resident memory T-cell content in recurrent laryngeal squamous cell carcinoma

Mann, Jacqueline E.; Smith, Joshua D.; Birkeland, Andrew C.; Bellile, Emily L.; Swiecicki, Paul; Mierzwa, Michelle; Chinn, Steven B.; Shuman, Andrew G.; Malloy, Kelly M.; Casper, Keith; McLean, Scott A.; Moyer, Jeffery; Wolf, Gregory T.; Bradford, Carol R.; Prince, Mark E.; Carey, Thomas E.; McHugh, Jonathan B.; Spector, Matthew E.; Brenner, J. Chad

doi:10.1007/s00262-018-2256-3

Cited by 39 publications

(42 citation statements)

References 27 publications

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“…In advanced LSCC we highlighted and confirmed the role of TILs as an independent prognostic factor 8 , 9 . Recently, different studies underline the role of the immune cell infiltrates in head and neck cancer.…”

Section: Discussionsupporting

confidence: 68%

“…The quality and quantity of TILs determines the antitumor response, being directly related with patients’ prognosis and DFS 10 . These data are reported not only for laryngeal cancer but also for HPV-positive oropharyngeal and tongue squamous cell carcinoma 8 – 10 , 27 .…”

Section: Discussionmentioning

confidence: 78%

“…Recent studies have characterized immune infiltrates in the tumor microenvironment (TME) of head and neck cancers and have suggested that low levels of stromal tumor infiltrating lymphocytes (TILs) are tightly associated with cancer relapses 8 – 10 . The quantity of the immune infiltrate is important to mount an efficient antitumor response and, in this regard, the transcriptional level of key genes involved in T cell and B cell function may reveal deregulation 11 .…”

Section: Introductionmentioning

confidence: 99%

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A role for the immune system in advanced laryngeal cancer

Tagliabue

Maffini

Fumagalli

et al. 2020

Sci Rep

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To investigate the role of the altered activation of the immune system in the prognosis of patients affected by laryngeal squamous cell carcinoma (LSCC). We analyzed 56 patients with advanced LSCC divided into two groups according to their prognosis: the first group relapsed within 24 months after treatment, the second group had no evidence of disease at 2 years. The presence of stromal tumor infiltrating lymphocytes (TILs) at the tumor-host border was investigated. In 43 patients we evaluated the expression of 395 genes related to immune system activation through a next generation sequencing panel. Priority-LASSO models and clustering analyses were integrated with multivariate Cox proportional hazard modeling to identify independent genes associated with relapse and estimate hazard ratios in relation to gene expression and TILs. TILs and the expression of genes related with immune system activation (FCGR1A, IFNA17, FCRLA, NCR3, KREMEN1, CD14, CD3G, CD19, CD20 and CD79A) were significantly associated with prognostic factors or disease specific survival. In patients with lymph node metastases and advanced T stage (pT4), the expression of other genes was altered. Low TILs count was highly associated with relapse within 2 years (p < 0.001). Low TILs and altered expression of specific genes associated with tumor-immune systems interactions emerged as independent risk factors, associated to poor prognosis and relapse within 2 years in advanced LSCC. Evaluation of patients’ immune profile could be useful for prognosis and future therapeutic approaches towards personalized therapy.

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Section: Discussionsupporting

confidence: 68%

Section: Discussionmentioning

confidence: 78%

Section: Introductionmentioning

confidence: 99%

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A role for the immune system in advanced laryngeal cancer

Tagliabue

Maffini

Fumagalli

et al. 2020

Sci Rep

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“…Recent findings have revealed an accumulation of CD103 + T RM cells in several human solid tumors including ovarian, [95][96][97] breast, 98 lung, [99][100][101][102] liver, 103 and urinary bladder 48 cancers. The abundance of these T RM cells has been associated with prolonged survival and better prognosis in patients with pulmonary squamous cell carcinoma (pSCC), 101 hepatocellular carcinoma (HCC), 103 triple-negative breast cancer (TNBC), 104 recurrent laryngeal squamous cell carcinoma (LSCC), 105 or HNSCC. 47 In addition, a high number of T RM cells infiltrating the tumors is associated with lower tumor stage in patients with UBC.…”

Section: Cd8 + T Rm Cells In Anti-tumor Immunitymentioning

confidence: 99%

Tissue-resident lymphocytes: from adaptive to innate immunity

et al. 2019

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Efficient immune responses against invading pathogens often involve coordination between cells from both the innate and adaptive immune systems. For multiple decades, it has been believed that CD8 + memory T cells and natural killer (NK) cells constantly and uniformly recirculate. Only recently was the existence of noncirculating memory T and NK cells that remain resident in the peripheral tissues, termed tissue-resident memory T (T RM) cells and tissue-resident NK (trNK) cells, observed in various organs owing to improved techniques. T RM cells populate a wide range of peripheral organs, including the skin, sensory ganglia, gut, lungs, brain, salivary glands, female reproductive tract, and others. Recent findings have demonstrated the existence of T RM in the secondary lymphoid organs (SLOs) as well, leading to revision of the classic theory that they exist only in peripheral organs. trNK cells have been identified in the uterus, skin, kidney, adipose tissue, and salivary glands. These tissue-resident lymphocytes do not recirculate in the blood or lymphatic system and often adopt a unique phenotype that is distinct from those of circulating immune cells. In this review, we will discuss the recent findings on the tissue residency of both innate and adaptive lymphocytes, with a particular focus on CD8 + memory T cells, and describe some advances regarding unconventional T cells (invariant NKT cells, mucosal-associated invariant T cells (MAIT), and γδ T cells) and the emerging family of trNK cells. Specifically, we will focus on the phenotypes and functions of these subsets and discuss their implications in anti-viral and anti-tumor immunity.

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“…Among the features that predict for good survival and/or successful (immuno-) therapy is the presence of tumour immune infiltrates that recognise cancer-associated antigens [ 22 , 23 , 24 ], providing histological evidence that the patient’s immune system is attempting immune attack. The impact on patient survival was found to be independent of the treatment regimens [ 25 , 26 ].…”

Section: Introductionmentioning

confidence: 99%

HNSCC: Tumour Antigens and Their Targeting by Immunotherapy

Witzleben

Wang

Laban

et al. 2020

Cells

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Head and neck squamous cell carcinomas (HNSCC) are a heterogeneous group of malignant tumours typically caused by alcohol and tobacco consumption, although an increasing number of HNSCC arise due to persistent infection with high-risk human papilloma virus (HPV). The treatment of HNSCC remains challenging, and the first-line setting is focused on surgery and chemoradiotherapy. A substantial proportion of HNSCC patients die from their disease, especially those with recurrent and metastatic disease. Among factors linked with good outcome, immune cell infiltration appears to have a major role. HPV-driven HNSCC are often T-cell rich, reflecting the presence of HPV antigens that are immunogenic. Tumour-associated antigens that are shared between patients or that are unique to an individual person may also induce varying degrees of immune response; studying these is important for the understanding of the interaction between the host immune system and the cancer. The resulting knowledge is critical for the design of better immunotherapies. Key questions are: Which antigens lead to an adaptive immune response in the tumour? Which of these are exploitable for immunotherapy? Here, we review the current thinking regarding tumour antigens in HNSCC and what has been learned from early phase clinical trials.

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Analysis of tumor-infiltrating CD103 resident memory T-cell content in recurrent laryngeal squamous cell carcinoma

Cited by 39 publications

References 27 publications

A role for the immune system in advanced laryngeal cancer

A role for the immune system in advanced laryngeal cancer

Tissue-resident lymphocytes: from adaptive to innate immunity

HNSCC: Tumour Antigens and Their Targeting by Immunotherapy

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