Analysis of Transfusion-Related Acute Lung Injury and Possible Transfusion-Related Acute Lung Injury Reported to the French Hemovigilance Network From 2007 to 2013

Andreu, G.; Boudjedir, Karim; Muller, Jean‐Yves; Pouchol, Elodie; Ozier, Yves; Fèvre, Guillaume; Gautreau, C.; Quaranta, Jean-François; Drouet, Christian; Rieux, Claire; Mertès, Paul-Michel; Clavier, B.; Carlier, M.; Sandid, Imad

doi:10.1016/j.tmrv.2017.07.001

Cited by 58 publications

(56 citation statements)

References 48 publications

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“…Hematologic malignancy is another condition with multiple TRALI risk factors (e.g., inflammation, multiple transfusions), although in one study, it remained an independent risk factor after correction for multiple transfusions . Other clinical conditions requiring multiple transfusions and associated with increased TRALI risk include intensive care unit patients admitted with gastrointestinal bleeding, abdominal aortic surgery, postpartum hemorrhage, stem cell transplantation, and thrombotic microangiopathy …”

Section: Resultsmentioning

confidence: 99%

A consensus redefinition of transfusion‐related acute lung injury

et al. 2019

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BACKGROUND Transfusion‐related acute lung injury (TRALI) is a serious complication of blood transfusion and is among the leading causes of transfusion‐related morbidity and mortality in most developed countries. In the past decade, the pathophysiology of this potentially life‐threatening syndrome has been increasingly elucidated, large cohort studies have identified associated patient conditions and transfusion risk factors, and preventive strategies have been successfully implemented. These new insights provide a rationale for updating the 2004 consensus definition of TRALI. STUDY DESIGN AND METHODS An international expert panel used the Delphi methodology to develop a redefinition of TRALI by modifying and updating the 2004 definition. Additionally, the panel reviewed issues related to TRALI nomenclature, patient conditions associated with acute respiratory distress syndrome (ARDS) and TRALI, TRALI pathophysiology, and standardization of reporting of TRALI cases. RESULTS In the redefinition, the term “possible TRALI” has been dropped. The terminology of TRALI Type I (without an ARDS risk factor) and TRALI Type II (with an ARDS risk factor or with mild existing ARDS) is proposed. Cases with an ARDS risk factor that meet ARDS diagnostic criteria and where respiratory deterioration over the 12 hours before transfusion implicates the risk factor as causative should be classified as ARDS. TRALI remains a clinical diagnosis and does not require detection of cognate white blood cell antibodies. CONCLUSIONS Clinicians should report all cases of posttransfusion pulmonary edema to the transfusion service so that further investigation can allow for classification of such cases as TRALI (Type I or Type II), ARDS, transfusion‐associated circulatory overload (TACO), or TRALI or TACO cannot distinguish or an alternate diagnosis.

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Section: Resultsmentioning

confidence: 99%

A consensus redefinition of transfusion‐related acute lung injury

et al. 2019

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“…The risk factors of severe transfusion-related diseases including TRALI and anaphylactic shock depend on patient's disease, number of transfusions, and history of adverse events. [6][7][8][9] Thus, it is necessary to list the patients who have ever had signs and symptoms after transfusion. We constructed a system of transfusion-associated signs and symptoms to be reported for all transfused patients, which made it possible to accurately assess the frequency of adverse reactions.…”

Section: Discussionmentioning

confidence: 99%

Analysis of Acute Transfusion Reactions and Their Occurrence Times

et al. 2018

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Acute transfusion reactions (ATRs) are significantly relevant to the morbidity and mortality of patients. ATRs are mostly not severe and rarely cause severe conditions, including anaphylactic shock. The aim of this study was to clarify the frequency of ATRs and the time of event occurrence. A total of 18,745 transfusions were administered to 11,718 patients during a 3-year period. Adverse reactions including at least one sign or symptom were collected through a report system in 143 of 2,478 (5.7%) platelet concentrate transfusions, 105 of 6,629 (1.6%) red blood cell component transfusions and 51 of 2,307 (2.2%) fresh frozen plasma transfusions. Allergic signs and symptoms accounted for 70% of all adverse events. Severe signs and symptoms were observed in 7.1% of patients. These events appeared significantly earlier than those of non-severe signs and symptoms (median time 20 min vs 100 min, P < 0.05). For patients who have had repetitive transfusion-associated adverse events, preventive treatments for adverse events should be proactively promoted.

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“…In the fourth case, the patient had a booster of known weakly anti‐HLA reactive DR7 donor‐specific antibodies, which was not taken into account in the first granulocyte transfusion. The development and booster of HLA antibodies is an inherent risk associated with granulocyte transfusions, and it is known that reverse TRALI is a severe complication after granulocyte transfusions . Systematic screening of patient's HLA antibodies before granulocyte infusion is therefore indicated, as was done in our patient.…”

Section: Discussionmentioning

confidence: 89%

Are we underestimating reverse TRALI?

Clippel¹,

Emonds

Compernolle

2019

Transfusion

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A 30-year-old woman diagnosed with aplastic anemia following parvovirus B19 infection was hospitalized from March 15 to March 29, 2016. The patient had had a successful kidney transplant in the past. The pretransfusion hemoglobin (Hb) was ABBREVIATIONS: HLA = human leukocyte antigen; HNA = human neutrophil antigen; MFI = mean fluorescence intensity; TRALI = transfusion-related acute lung injury.From the

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Analysis of Transfusion-Related Acute Lung Injury and Possible Transfusion-Related Acute Lung Injury Reported to the French Hemovigilance Network From 2007 to 2013

Cited by 58 publications

References 48 publications

A consensus redefinition of transfusion‐related acute lung injury

A consensus redefinition of transfusion‐related acute lung injury

Analysis of Acute Transfusion Reactions and Their Occurrence Times

Are we underestimating reverse TRALI?

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