Analysis of total immunoglobulin E and specific immunoglobulin E of 3,721 patients with allergic disease

Abstract

Abstract. Due to the increase in the prevalence and incidence of allergic diseases, improving the sensitivity and specificity of screening indexes is critical. Total immunoglobulin E (IgE) is a traditional index for judging allergic diseases, while its specificity is relatively poor. Serum-specific IgE (sIgE) is an objective index with high specificity in the diagnosis of allergic diseases. In the present research, the total IgE and sIgE of 3,721 patients with allergic diseases were analyzed to further illuminate the association between them. The data were derived from 3,721 patients. The serum-sIgE to 14 types of common allergens and total IgE were detected. A total of 2,419 cases (65.0%) of 3,721 patients exhibited increasing total IgE and 1,215 patients (32.7%) exhibited positive sIgE. The consistency rate of the two indexes was 60.4%, and the κ-value was 0.28. In 135 patients with normal total IgE, 82.2% exhibited one sIgE positive and 17.8% exhibited two or more sIgE positive. While the number of positive sIgE increased and the detecting level enhanced, the number of positive total IgE markedly increased. Patients (84.1%) with increasing total IgE were associated with positive sIgE, but the increase of total IgE could not be completely explained by the total accumulation of sIgE. Total IgE may play an important role on screening allergic disease while sIgE could be used as crucial evidence for allergy diagnosis. Although the consistency of the two methods was poor, neither total IgE nor sIgE could replace each other. Combining the two indexes with clinical manifestations together will improve the method.

Diamine oxidase enzyme: a novel biomarker in respiratory allergy

“…High levels of circulating IgE can be found in various diseases, including infections, primary immunodeficiency, inflammatory diseases, hyper‐IgE syndrome, and malignancies . Although IgE measurement is helpful in screening for respiratory allergies, other diagnostic tools are mandatory for complete evaluation . On the other hand, the present study found that the DAO test had a high sensitivity and negative predictive values, and therefore, may be a promising test to rule out the presence of allergic disease.…”

“…Total IgE is a poor test because numerous factors affect its level, and therefore, can seldom be used in diagnosis of allergic disease. Although normal values of total IgE cannot exclude the presence of allergic disease, high values of total IgE also cannot prove incidence of allergy . High levels of circulating IgE can be found in various diseases, including infections, primary immunodeficiency, inflammatory diseases, hyper‐IgE syndrome, and malignancies .…”

Testes laboratoriais de triagem para doenças alérgicas: ainda têm espaço na prática clínica?

“…A eleição de ponto de corte para identificar um indivíduo alérgico do não alérgico com relação à concentração sérica de IgE total tem sido assunto controverso. Alguns autores têm adotado valores arbitrários de IgE sérica total de 100 UI/mL para o diagnóstico de possível doença atópica 25,30,31 . Já para Hamilton e cols.…”

“…Segundo os autores, embora a IgE total seja empregada na triagem de doenças alérgicas, a IgE específica pode ser usada como evidência para o diagnóstico de alergia. A consistência entre os dois métodos foi baixa e recomendam que devam ser usados em combinação às manifestações clínicas para melhorar o método diagnóstico 31 .…”

Exposure to mould allergens and rhinoconjunctivitis in Korean children

“…Serum immunoglobulin E (IgE) is a good predictor of allergic disease since allergies cause inflammation . However, total IgE has a relatively poor specificity because high level of total IgE was associated with allergic disease as well as other diseases . Although studies have suggested that a critical level of IgE could diagnose allergic disease , the levels of total IgE vary among individuals and increase with age .…”