Analysis of the T Descriptors and Other Prognosis Factors in Pathologic Stage I Non-small Cell Lung Cancer in China

Li, Ziming; Yang, Yu; Lu, Jiade J.; Luo, Qinquan; Wu, Chunxiao; Liao, Meilin; Zheng, Ying; Ai, Xinghao; Gu, Lingping; Lü, Shun

doi:10.1097/jto.0b013e3181a5269d

Cited by 39 publications

(34 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In this study, no statistically significant effect was detected between patients aged <65 years and those aged >65 years when compared in terms of their survival rates (p=0.885). Some studies that assessed the relationship between sex and survival reported that women have higher survival rates than men (7)(8)(9)(10)(11)17). However, other studies, including ours, determined that sex had no effect on survival (p=0.924) (14-16).…”

Section: Discussionmentioning

confidence: 71%

“…Lobectomy or bilobectomy was found to be superior to pneumonectomy in terms of survival rates in a series of 6.644 patients diagnosed with NSCLC (p=0.01) (8). A study on the prognosis of stage 1 NCSLC patients stated that survival rates in the lobectomy or bilobectomy group were higher than those in the pneumonectomy group (p=0.021) (9). There was no significant difference in terms of disease-free survival (p=0.2422).…”

Section: Discussionmentioning

confidence: 93%

“…Demographic characteristics of patients, smoking history, tumor histology, tumor stage, and genetic factors are all thought to influence prognosis. When the effect of age on survival rate was examined, patients aged <65 years had high survival rates (7)(8)(9). When based on different age groups, some studies reported no statistically significant differences, whereas others showed significant differences between survival and age (10)(11)(12)(13)(14)(15)(16).…”

Section: Discussionmentioning

confidence: 99%

“…In multivariate analysis, there were no significant differences among the histologic types. However, numerous studies have indicated that there is no statistically significant relationship between survival and histopathologic type (7)(8)(9)(10)14). Generally, study groups on thoracic oncology consider adenocarcinomas to have worse prognosis than epidermoid carcinomas.…”

Section: Discussionmentioning

confidence: 99%

See 3 more Smart Citations

Evaluation of Prognostic Factors for Survival in Stage I Non-small Cell Lung Carcinoma

Gürler¹,

Önal²,

Demir³

2017

Erciyes Med J

View full text Add to dashboard Cite

Objective: Surgical resection is currently considered the most appropriate treatment option in early-stage lung cancer. However, surgical treatment of early-stage patients still results in different survival times. The aim of this study was to evaluate the effects of age, sex, smoking history, tumor size, localization, histopathologic type, and resection type on survival after surgically resected pathologic stage 1 non-small cell lung cancer (NSCLC). Materials and Methods:Sixty consecutive patients who underwent surgical treatment between July 2006 and January 2011 for pathologic stage 1 primary lung cancer were included in this study.Results: Fifty-five (91.7%) of the patients were males, and they were 46-88 (median, 64.4±8.5) years old. Age, sex, smoking history, histopathologic type, anatomical localization, stage, resection type, and postoperative complications did not affect survival rates. Patients with incomplete resection or metastases during the follow-up period had statistically significant decreased survival rates.Conclusions: Staging according to anatomical markers in stage 1 NSCLC patients is not prognostically decisive. Therefore, we believe that staging in NSCLC may be accomplished according to not only anatomic indicatives but also molecular markers.

show abstract

Section: Discussionmentioning

confidence: 71%

Section: Discussionmentioning

confidence: 93%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Evaluation of Prognostic Factors for Survival in Stage I Non-small Cell Lung Carcinoma

Gürler¹,

Önal²,

Demir³

2017

Erciyes Med J

View full text Add to dashboard Cite

show abstract

“…Both the worsening of the risk factors for the disease and the aging of population may be the two major contributors to current status. Lung cancer has become one of the most common malignant neoplasm in China [1,2]. The majority of patients are already in a fairly advanced stage when they first seek medical attention and only 25-30% of patients can be offered therapeutic resection at most [3].…”

mentioning

confidence: 99%

Fiber-optic bronchoscope and detection of lung cancer: A five year study

Gao

Asmitanand²,

Ren³

et al. 2012

neo

View full text Add to dashboard Cite

White light bronchoscopy [WLB] has been used for identification and localization of intra-epithelial pre-neoplastic and neoplastic lesions within the bronchus. Aim of the study was to evaluate the uses of WLB to detect and localize the precancerous and cancerous lesions, and in addition to analyze morphologic presentation, and association to histological type and the variation between genders.A total of 4983 patients were examined by WLB from 2004 to 2009 in a local tertiary teaching hospital. The following parameters were collected: morphological presentation, biopsy sites, histology. The patients' records of age, sex, smoking status, blood-gas, X-RAY/CT, CBC, ECG, PT, and APTT were obtained for analysis. Differences between the patients groups were analyzed using Chi square test.1489 patients who had hyperplasia or neoplasic lesions were further confirmed as having lung cancer pathologically. Lung cancer was more commonly found in the right lung (51.58% vs 42.82%). The upper lobe was more frequently found to have lesions (44.17% vs 22.42%) than the lower lobe. Male patients with squamous cell carcinoma showed more commonly upper lobe involvement, while left main bronchus was more commonly involved in female patients. Adenocarcinoma was mostly involved in lesions of the upper lobe. Proliferative type was found in 80.15% of squamous cell carcinoma cases and in 76.16 % of small cell carcinoma cases.Fiberoptic bronchoscopy is an effective method for the detection of preinvasive neoplasic lesions. The morphological presentation is associated to histological type. There is variation in presentation and histology of cancerous lung lesion between the genders.

show abstract

Prognostic value of MMP9 activity level in resected stage I B lung adenocarcinoma

et al. 2016

Self Cite

View full text Add to dashboard Cite

The clinical outcomes of patients with early‐stage non‐small cell lung cancer (NSCLC) have remained unsatisfactory after complete surgical resection. The objective of this study was to explore the prognostic value of matrix metalloproteinase 9 (MMP9) activity level in Chinese patients with stage I B lung adenocarcinoma. A sensitive and validated method was employed for determining the activity of MMP9 in human lung adenocarcinoma cells in vitro. Then, the association was examined between the level of MMP9 enzymatic activity and clinical outcomes. A total of 104 cases were stratified according to the IASLC/ATS/ERS classification scheme and activity of MMP9 was analyzed by SensoLyte® assay kit. The results showed that the MMP9 activity was the highest in solid predominant and micropapillary predominant subtypes, intermediate in acinar predominant and papillary predominant subtypes, and the lowest in lepidic predominant subtype. Multivariate analysis revealed that pathological subtype and activity of MMP9 were independent prognostic factors for disease‐free survival (DFS), respectively (P = 0.005 and 0.029). Significant relationship existed between enzyme activity of MMP9 and prognosis. And the 30 months DFS of high‐ and low‐level MMP9 activity tumors was 44.2% and 84.1% (P < 0.0001), respectively. High‐level MMP9 activity is correlated with aggressive tumor behaviors and poor clinical outcomes in early‐stage lung adenocarcinoma after complete resection.

show abstract

Analysis of the T Descriptors and Other Prognosis Factors in Pathologic Stage I Non-small Cell Lung Cancer in China

Abstract: The tumor size is a significant independent prognostic factors in stage I NSCLC.

Cited by 39 publications

References 33 publications

Evaluation of Prognostic Factors for Survival in Stage I Non-small Cell Lung Carcinoma

Evaluation of Prognostic Factors for Survival in Stage I Non-small Cell Lung Carcinoma

Fiber-optic bronchoscope and detection of lung cancer: A five year study

Prognostic value of MMP9 activity level in resected stage I B lung adenocarcinoma

Contact Info

Product

Resources

About

Analysis of the T Descriptors and Other Prognosis Factors in Pathologic Stage I Non-small Cell Lung Cancer in China

Abstract: The tumor size is a significant independent prognostic factors in stage I NSCLC.

Cited by 39 publications

References 33 publications

Evaluation of Prognostic Factors for Survival in Stage I Non-small Cell Lung Carcinoma

Evaluation of Prognostic Factors for Survival in Stage I Non-small Cell Lung Carcinoma

Fiber-optic bronchoscope and detection of lung cancer: A five year study

Prognostic value of MMP9 activity level in resected stage I B lung adenocarcinoma

Contact Info

Product

Resources

About

Fiber-optic bronchoscope and detection of lung cancer: A five year study