Introduction. The regional programs of the subsidized provision of medicines (RPSPM) implemented in the subjects of the Russian Federation are an important state instrument in the field of medicine provision of citizens. Purpose. To study the features of the implementation of RPSPM in various subjects of the Russian Federation over 2018-2019. Material and methods. During the study, the data provided by the health authorities and the pharmaceutical service of 21 constituent entities of the Russian Federation were processed. Results. The median of funding in the studied subjects of the Russian Federation amounted to 713.1 million rubles in 2018 and 753.1 million rubles in 2019. The average actual costs per one applied beneficiary (± standard error) was 2685 ± 941 rubles in 2018 and 2404 ± 780 rubles in 2019. At the end of 2018, about 22.7 million prescriptions were established to be written out in the analyzed subjects of the Russian Federation within the framework of the RPPPM, at the end of 2019 - about 26.2 million prescriptions. The median cost of one prescription reached 1,327 rubles in 2018 and 2,162 rubles in 2019. Comparative analysis showed that the indicators of the funding volume for the RPSPM per beneficiary per year in different subjects of the Russian Federation differ significantly, the median (interquartile range) in 2018 was 6,704 rubles (3,436-11,576 rubles), in 2019 - 8,166 rubles (4,162-10,211 rubles). Limitations. Taking into account the administrative-territorial division of the Russian Federation, in the study we analyzed data on the implementation of the RPSPM for about 25% of the constituent entities of the Russian Federation with various infrastructural, socio-economic, demographic indicators, which is a fairly reference sample group. Conclusion. Thus, we studied the indicators of the implementation of the RPSPM in 21 subjects of the Russian Federation. During 2018-2019 in the analyzed subjects of the Russian Federation, regional beneficiaries had different opportunities to receive medicine assistance within the framework of the RPSPM.