“…Despite a focus on links between serotonergic and cholinergic transmitter systems (Ahlander-Luttgen et al, 2003;Hu et al, 2007;Rutz et al, 2006;Wolff et al, 2003a,b), modulation of glutamatergic currents has also been demonstrated in a variety of brain regions (Bouryi and Lewis, 2003;Lemos et al, 2006;Li and Bayliss, 1998;Muramatsu et al, 1998). Here, it is thought that 5-HT 1B R activation exerts an effect through pre-synaptic mechanisms, predominantly via action as inhibitory auto-and/or heteroreceptors, thereby modulating neurotransmitter release (Sari, 2004).…”