Analysis of the Retinal Nerve Fiber Layer in Retinitis Pigmentosa Using Optic Coherence Tomography

Yıldırım, Medine Aslı; Erden, Burak; Tetikoğlu, Mehmet; Kuru, Özlem; Elçioğlu, Mustafa Nuri

doi:10.1155/2015/157365

Cited by 7 publications

(3 citation statements)

References 26 publications

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“…However, the RNFL thickness was found to be retained or thickened in the majority of RP patients, and the measurement results are shown in table 2[44,53,54,55,56,57,58]. In addition to the mean RNFL changes [44,55], the quadrants of the RNFL thickening or thinning were different.…”

Section: Retinal Nerve Fiber Layermentioning

confidence: 99%

Optical Coherence Tomographic Analysis of Retina in Retinitis Pigmentosa Patients

Liu

Liu²,

Li³

et al. 2016

Ophthalmic Res

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Retinitis pigmentosa (RP) is a progressive inherited retinal disease characterized by nyctalopia, visual field constriction, and reduced full-field electroretinograms. The progressive loss of photoreceptors leads to vision loss at the end stage of RP. The prevalence of RP is approximately 1/4,000. Since it is one of the major causes of visual impairment worldwide, morphological and functional assessments are useful for estimating the retinal structure and function in RP. Optical coherence tomography (OCT) is a well-established method of examining retinal structure in situ, and the obtained images by OCT help to analyze morphological abnormalities. Changes revealed by OCT have provided insights into the pathology of RP as well as for predicting the prognosis of RP. In this review, we present the typical morphological changes in RP and their relationships with visual function in eyes with RP.

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Section: Retinal Nerve Fiber Layermentioning

confidence: 99%

Optical Coherence Tomographic Analysis of Retina in Retinitis Pigmentosa Patients

Liu

Liu²,

Li³

et al. 2016

Ophthalmic Res

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“…One explanation could be the topographic distribution of the radial peripapillary capillary plexus (RPPC), which is not noticeable in the temporal sector of the macula compared to the inferior and superior sectors. The RPPC contributes to the SVC together with the superficial capillary plexus (SCP) and is usually preserved in RP as is the thickness of the retinal nerve fiber layers 25,26 . In the 6 × 6-mm OCTA, the SVC density measures globally the www.nature.com/scientificreports/ density of both the SCP and RPPC, hence, the decrease of the SVC density in the superior and inferior sectors could be masked by the normal density of the RPPC.…”

Section: Discussionmentioning

confidence: 99%

Near-infrared fundus autofluorescence alterations correlate with swept-source optical coherence tomography angiography findings in patients with retinitis pigmentosa

Nassisi

Lavia

Mohand‐Saïd

et al. 2021

Sci Rep

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Thirty-eight patients from 37 families with retinitis pigmentosa (RP) underwent macular 6 × 6-mm swept-source optical coherence tomography angiography (SS-OCTA) and 30° near-infrared fundus autofluorescence (NIR-FAF) acquisitions in one eye. Superficial vascular complex (SVC), deep capillary complex (DCC) and choriocapillaris (CC) angiograms were registered with NIR-FAF acquisitions to comparatively assess subjects with and without central area of preserved NIR-FAF (APA). On the subset of patients showing an APA, the vessel densities for SVC and DCC and flow deficits for CC were assessed in three directions (superior, inferior and temporal) from the fovea and compared to healthy 1:1 age-matched controls. Nine patients with no APA had evidence of severe central OCTA alterations at all levels, especially in the DCC. In the other 29 subjects presenting APA, all OCTA parameters were similar to healthy eyes within the APA, where the retina preserves its structural integrity. Outside the APA, both the DCC and CC were significantly reduced in all directions. These alterations are probably related to the outer retinal atrophy outside the APA. Comparing OCTA to other imaging modalities is helpful to determine the potential interest of OCTA findings as an outcome measure for disease status and progression.

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“…Walia et al reported RNFL thinning in approximately 40% of RP patients using SD-OCT[25] and Oishi et al reported no signi cant difference between RNFL thickness in normal populations and RP patients using time domain OCT[26]. Yilldirim et al reported that 48% of patients had temporal quadrant RNFL thickening and suggested that glial tissue proliferation, which is secondary to the nerve ber layer atrophy or edema of the remnant RNFL, causes the retinal thickening[27]. These results indicate that RNFL thinning may not be linear and may vary from one stage to another of degeneration.…”

mentioning

confidence: 99%

Multimodal imaging of the optic nerve head in retinitis pigmentosa

Wada

Takagi

Yoshikawa

et al. 2023

Preprint

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Background: A pallor optic nerve head (ONH) is one of the three features in retinitis pigmentosa (RP). This study aimed to assess the ONH by color tone, presence of hyper-reflective structure, blood flow, and retinal nerve fiber layer (RNFL) thickness, and investigate the change in these parameters with and without ONH pallor. Methods: The presence of ONH pallor was assessed by three independent examiners through careful examination using fundus photographs. The presence of a hyper-reflective structure on the ONH was carefully evaluated using a volume scan optical coherence tomography (OCT). RNFL thickness and ellipsoid zone (EZ) width around the macula were also evaluated by OCT. Laser speckle flowgraphy was used to measure the mean blur rate of the entire ONH area, which was subsequently divided into the vessel area (MV) and tissue area (MT). Results: Twenty-eight eyes of 28 patients with RP (55.4±16.23 years old) were included. The pale ONH was observed in 10 (35%) eyes. Hyper-reflective structures were observed in 7 (25%) eyes. No significant correlation was found between the pale ONH and presence of a hyper-reflective structure (Pearson’s chi-squared test, p=0.364). The average of the ONH area, MV, and MT was 8.65±3.08 AU, 17.81±7.54 AU, and 6.4±2.66 AU, respectively, which significantly decreased in patients with pallor ONH (all p<0.05). The global RNFL thickness was 73.54±18.82 μm. The nasal and superior quadrants and global RNFL thickness in patients with a pale ONH were significantly thinner than in patients without a pale ONH (all p<0.05). There was no difference in the EZ width between patients with and without a pale ONH (p=0.107). Conclusion: We conducted multiple assessments of the ONH in patients with RP and investigated its clinical significance. Our findings suggest that ONH pallor may indicate a comprehensive change that emerges alongside the progression of retinal degeneration in RP. Trial registration: This trial was retrospectively registered in the UMIN Clinical Trial Registry(UMIN000048168 01/07/2022).

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Analysis of the Retinal Nerve Fiber Layer in Retinitis Pigmentosa Using Optic Coherence Tomography

Cited by 7 publications

References 26 publications

Optical Coherence Tomographic Analysis of Retina in Retinitis Pigmentosa Patients

Optical Coherence Tomographic Analysis of Retina in Retinitis Pigmentosa Patients

Near-infrared fundus autofluorescence alterations correlate with swept-source optical coherence tomography angiography findings in patients with retinitis pigmentosa

Multimodal imaging of the optic nerve head in retinitis pigmentosa

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