Purpose: To compare tear film osmolarity (TFO) between patients with diabetes mellitus (DM) and normal healthy individuals. Methods: In this prospective case-controlled study, the TFO in 46 normal subjects (control group) and 55 patients with DM (study group) was evaluated. TFO in milliosmole (mOsm) was measured by using an auto-osmometer. The serum levels of glycosylated hemoglobin (HbA₁c) and blood glucose in all participants were also measured. Mean outcome measures were TFO and its relationship with HbA1c level and duration of DM. Results: Mean TFO was 320.40 ± 21.80 mOsm/l in the study group and 308.22 ± 18.16 mOsm/l in the control group (p < 0.001). The TFO values were significantly associated with duration of DM (r = 0.476, p < 0.001), but no significant correlation was found with HbA₁c level (r = 0.225, p = 0.114). Conclusions: The study shows a significantly higher TFO in patients with DM than in the healthy controls. TFO also correlates with the duration of DM.

Objectives: To evaluate dry eye symptoms and clinical tear film alterations in patients with chronic renal failure (CRF). Materials and methods: Thirty-five non-diabetic CRF patients undergoing hemodialysis, and 31 healthy individuals were enrolled. An ocular surface disease index questionnaire (OSDI) was administered, and after a complete ocular examination, Schirmer and tear break-up time (TBUT) tests were performed. Results: OSDI scores were significantly higher (p50.01) and TBUT tests were significantly lower (p ¼ 0.01) in CRF patients than in the control group. Schirmer test results were also lower in the CRF patients group, but lacked statistical significance (p ¼ 0.20). Conclusion: Patients with CRF should be advised to obtain an ophthalmic examination, especially for dry eye.

Smoking results in increased osmolarity of the tear film, which can damage the ocular surface and tear function.

The purpose of this study was to compare the efficacy and safety of selective laser trabeculoplasty (SLT) for patients with primary open-angle glaucoma (POAG) and pseudoexfoliative glaucoma (PXG). In this retrospective case series, 85 eyes (48 POAG, 37 PXG) of 85 patients were investigated. The medical records of patients who underwent SLT for POAG or PXG were reviewed. The main outcome measures included intraocular pressure (IOP)-lowering effect and ocular side effects. The mean decrease in IOP differed significantly (p < 0.001) between eyes with POAG (-4.4 ± 2.1 mmHg) and eyes with PXG (-6.1 ± 3.6 mmHg) at a mean follow-up period of 1 year. The rate of side effects, such as early IOP spike and uveitis, did not significantly differ between the two groups. In conclusion, SLT has a greater IOP-lowering effect in PXG compared with POAG.

High MPV values may be an important risk factor for the development of PDR and DME in patients with diabetic retinopathy.