Analysis of the performance of a two-stage fermentor with cell recycle for continuous ethanol production using different kinetic models

Nishiwaki, Akio; Dunn, Irving J.

doi:10.1016/s1369-703x(99)00029-7

Cited by 28 publications

(10 citation statements)

References 14 publications

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“…5. Distinction between the volume fraction of wet cells (biotic phase) and that of surrounding liquid (abiotic phase) in the culture broth was taken into account [8,9,19,20]. The biomass concentrations expressed as g cell dry weight l À1 were calculated based on the total volume.…”

Section: Methodsmentioning

confidence: 99%

“…With a microfiltration system, Groot et al [5] demonstrated that the ethanol productivity could be increased to 55 g l À1 h À1 with concomitant ethanol and glucose concentrations of 53 and 183 g l À1 , respectively. However, due to (1) the inhibitory effect of the ethanol concentration on the yeast growth and ethanol production, and (2) the uncoupling between growth and ethanol production above high ethanol concentration, theoretical approaches [8,9] showed that recycle twostage continuous fermentations with membrane separator would be potentially the most efficient system for improving ethanol productivity. In these numerical works, the proposed configuration was a first stage dedicated to cell growth and a second stage to ethanol production in a bioreactor coupled to an external membrane module in order to reach high cell density.…”

Section: Introductionmentioning

confidence: 99%

“…In these numerical works, the proposed configuration was a first stage dedicated to cell growth and a second stage to ethanol production in a bioreactor coupled to an external membrane module in order to reach high cell density. Nishiwaki and Dunn [8,9] demonstrated numerically that this system was more efficient than either a recycle chemostat or a two-stage bioreactor with a single separator after the final stage. At the optimum dilution rate, Nishiwaki and Dunn demonstrated numerically that for the two-stage reactor with membrane ultrafiltration, the ethanol productivity and the substrate conversion were higher than for the other configurations.…”

Section: Introductionmentioning

confidence: 99%

“…Moreover, the total fermentor volume of the two-stage system was always found to be smaller than that of a single one with recycling: therefore, their prediction made the two-stage configuration attractive for practical evaluation. However, no experimental demonstration on recycle two-stage continuous systems have been reported in the literature since Nishiwaki and Dunn predictive works were published in 1999 [9].…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Very high ethanol productivity in an innovative continuous two-stage bioreactor with cell recycle

Chaabane

Aldiguier

Alfenore³

et al. 2006

Bioprocess Biosyst Eng

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The performance of an innovative two-stage continuous bioreactor with cell recycle-potentially capable of giving very high ethanol productivity-was investigated. The first stage was dedicated to cell growth, whereas the second stage was dedicated to ethanol production. A high cell density was obtained by an ultrafiltration module coupled to the outlet of the second reactor. A recycle loop from the second stage to the first one was tested to improve cell viability and activity. Cultivations of Saccharomyces cerevisiae in mineral medium on glucose were performed at 30 degrees Celsius and pH 4. At steady state, total biomass concentrations of 59 and 157 gDCW l(-1) and ethanol concentrations of 31 and 65 g l(-1) were obtained in the first and second stage, respectively. The residual glucose concentration was 73 g l(-1) in the first stage and close to zero in the second stage. The present study shows that a very high ethanol productivity (up to 41 g l(-1) h(-1)) can indeed be obtained with complete conversion of the glucose and with a high ethanol titre (8.3 degrees GL) in the two-stage system.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Very high ethanol productivity in an innovative continuous two-stage bioreactor with cell recycle

Chaabane

Aldiguier

Alfenore³

et al. 2006

Bioprocess Biosyst Eng

View full text Add to dashboard Cite

show abstract

“…In such recycle systems, the cell concentration can also reach high levels, leading to improved productivities. Membrane-based cell recycle fermentation has been proved to be efficient in producing primary and secondary metabolites such as lactic acid, xylitol, and ethanol (Bae et al, 2004;Nishiwaki and Dunn, 1999;Oh et al, 2003;Roca and Olsson, 2003). In addition, repeated batch fermentation gave several ad-vantages of timesaving processes for cleaning, sterilization and inoculation.…”

Section: Introductionmentioning

confidence: 99%

Production of pentocin 31-1 by high cell density Lactobacillus pentosus 31-1 repeated batch cell recycle fermentations

Gui¹,

Li²

2013

Afr. J. Microbiol. Res.

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Pentocin 31-1 was produced by Lactobacillus pentosus 31-1, isolated from the traditional Chinese fermented Xuan-Wei Ham. The wide range of antimicrobial activity especially to Listeria spp showed its potential use as food preservative. The study of pentocin 31-1 production was carried out in repeated batch cell recycle fermentations in 5 L bioreactor and up to 50 L pilot bioreactor. Batch fermentation of L. pentosus 31-1 gave bacteriocin production and productivity of 1395.3 IU/mL and 66.4 IU/(mL h), respectively. The higher bacteriocin production (2186.2 and 2004.5 IU/mL, respectively) and productivity (260.7 and 237.4 IU/(mL h), respectively) was measured in repeated batch cell recycle fermentations in 5 and 50 L bioreactors. Biomass (4.8 and 5.8 g/L, respectively) were also increased with repeated batch cell recycle fermentations in 5 and 50 L bioreactors, which were equivalent to 1.48-and 1.8-fold increases compared with the biomass (3.2 g/L) obtained from batch fermentation. Fermentations were successfully scaled up from 5 to 50 L because there were no significant differences (p<0.05) in production and productivity of bacteriocin between the two volumes by using the same strain and fermentation conditions. These results suggest a reasonable solution to develop large-scale production of both pentocin 31-1 and L. pentosus 31-1 in food industry.

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Recent Advances in Production of Bioethanol from Lignocellulosic Biomass

et al. 2009

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Ethanol is considered the most potential next generation automotive fuel because it is carbon-neutral and could be produced from renewable resources like lignocellulosic biomass. There are some technological barriers such as pretreatment, saccharification of cellulose and hemicellulose matrix, and simultaneous fermentation of hexose and pentose sugars which needs to be addressed for efficient conversion of lignocellulosic biomass to bioethanol. This paper reviews the various process options and kinetic models adopted towards resolving the technological challenges to develop a low-cost commercial process.

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Analysis of the performance of a two-stage fermentor with cell recycle for continuous ethanol production using different kinetic models

Cited by 28 publications

References 14 publications

Very high ethanol productivity in an innovative continuous two-stage bioreactor with cell recycle

Very high ethanol productivity in an innovative continuous two-stage bioreactor with cell recycle

Production of pentocin 31-1 by high cell density Lactobacillus pentosus 31-1 repeated batch cell recycle fermentations

Recent Advances in Production of Bioethanol from Lignocellulosic Biomass

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