Analysis of the parameters of oxidative stress in patients with Parkinson’s disease

Nikolova, Galina; Mancheva, Velina

doi:10.1007/s00580-012-1407-8

Cited by 9 publications

(7 citation statements)

References 29 publications

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“…Maximum studies were conducted in an Asia continent. 10 studies were conducted in India, 12 , 15 - 17 , 19 , 20 , 22 - 25 and the others were from Taiwan, 25 Romania, 18 Bulgaria, 11 Spain, 14 Germany, 10 Brazil, 13 and Turkey. 21 Both male and female sexes were included in all studies.…”

Section: Resultsmentioning

confidence: 99%

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Oxidative stress-related biomarkers in Parkinson’s disease: A systematic review and meta-analysis

Khan¹,

Ali²

2019

CJN

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Parkinson’s disease (PD) is a neurodegenerative disease characterized with the loss of dopamine-producing neurons in a mid-brain. This loss is believed to be associated with number of environmental and genetic factors. Oxidative stress is found to be one of the factors responsible for the initiation and progression of PD. However, studies are still continued to confirm the connection and mechanism associated with oxidative stress and PD. This systematic review and meta-analysis aimed to assess the association between oxidative stress markers and PD, and explore factors that may elucidate the contradictions in these results. As per Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guideline systematic literature search was carried out. Meta-analysis was carried out on pooled standardized mean differences with 95% confidence interval (CI) of patients with PD and controls using random effect model in comprehensive meta-analysis statistical software. Total 17 studies were included into which 25 oxidative stress markers were analyzed. The results revealed that oxidative stress markers [nitrate and nitric oxide (NO)] and antioxidant markers [total antioxidant status (TAS) and thiols] were not statistically different between the PD and control group (P > 0.05). In case of oxidative stress markers, levels of malondialdehyde (MDA), 8-Oxo-2'-deoxyguanosine (8-oxo-dG), and lipid hydro-peroxide (LPO) were found to be high in patients with PD as compared to controls with P < 0.05, whereas lower levels of antioxidant activity of superoxide dismutase (SOD), glucose 6 phosphate dehydrogenase (G6PD), catalase (CAT), and glutathione peroxidase (GPx) were noticed in the PD group as compared to controls (P < 0.05 for all). From the results, it is concluded that patients with PD have high oxidative stress and lower antioxidant activity, and these studied biomarkers would be used as potential diagnostic tool to measure oxidative stress in patients with PD.

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Section: Resultsmentioning

confidence: 99%

“…Out of the 25 studies, 17 met the inclusion criteria for addition to the review. [10][11][12][13][14][15][16][17][18][19][20][21][22][23][24][25][26] Included studies were conducted in 9 different countries. Maximum studies were conducted in an Asia continent.…”

Section: Methodsmentioning

confidence: 99%

Oxidative stress-related biomarkers in Parkinson’s disease: A systematic review and meta-analysis

Khan¹,

Ali²

2019

CJN

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“…This is a slow, progressive disease, characterized by loss of dopaminergic neurons in the Subs-tantia Nigra (SN) pars compacta [1]. To explain the neurodegenerative mechanisms that occur in PD, numerous hypotheses have been proposed and some of them show that oxidative stress plays a considerable role [2]- [5]. Imbalance between levels of reactive oxygen species (ROS) resulting in the body and the capacity of antioxidant defense mechanisms provokes oxidative stress (OS).…”

Section: Introductionmentioning

confidence: 99%

Influence of Therapy on Some Important Final Products of Oxidation of Lipids, Proteins and Nucleic Acids in Patients with Parkinson’s Diseases

Nikolova¹,

Grigorov²,

Zheleva³

et al. 2014

ABC

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The major clinical disturbances in Parkinson's disease (PD) are consequence of dopamine depletion in the neostriatum, due to degeneration of dopaminergic neurons. The aim of the present study was to determine whether oxidative stress (OS) occurs during the clinical course of Parkinson's disease and to evaluate the influence of therapy on the levels of some important final products of oxidation of lipids, proteins and nucleic acids in PD patients with drug therapy. For this purpose, we investigated the levels of malondialdehid (MDA), protein carbonyl content (PCC) and 8hydroxy-2'-deoxyguanosine quantity (8-OHdG) in PD patients with and without drug therapy. The observed changes in MDA levels, PCC and 8-OHdG quantity in blood of untreated PD patients, suggested impaired antioxidant status and presence of oxidative stress in Parkinson disease. After treatment with Madopar, the elevation in by-products significantly progresses. Our results demonstrate that administration of Madopar causes in greater degree oxidative stress than that induced by Parkinson disease, by itself.

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“…(36). Thus, mitochondria are the main source of intracellular ROS (e.g., superoxide and hydrogen peroxide) ( Figure 3) (26,(37)(38)(39)(40)(41). The production of ROS in mitochondria is tightly regulated by the mitochondrial superoxide dismutase (SOD2) and glutathione-peroxidase (GPx), as well as by catalase and non-enzymatic antioxidants.…”

Section: Role Of Mitochondria In "Free Radical Pathologies"mentioning

confidence: 99%

Mitochondrial Dysfunction and Redox Imbalance as a Diagnostic Marker of “Free Radical Diseases”

2017

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Analysis of the parameters of oxidative stress in patients with Parkinson’s disease

Cited by 9 publications

References 29 publications

Oxidative stress-related biomarkers in Parkinson’s disease: A systematic review and meta-analysis

Oxidative stress-related biomarkers in Parkinson’s disease: A systematic review and meta-analysis

Influence of Therapy on Some Important Final Products of Oxidation of Lipids, Proteins and Nucleic Acids in Patients with Parkinson’s Diseases

Mitochondrial Dysfunction and Redox Imbalance as a Diagnostic Marker of “Free Radical Diseases”

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