Oxidative stress-related biomarkers in Parkinson’s disease: A systematic review and meta-analysis

Khan, Zahid H.; Ali, Sharique A.

doi:10.18502/ijnl.v17i3.373

Cited by 22 publications

(24 citation statements)

References 24 publications

(27 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In a meta-analysis of observational studies, lower levels of SOD, CAT and GPx were found in persons with coronary heart disease (CHD) [ 186 ]. Decreased activity of these enzymes was also observed in a meta-analysis in subjects with Parkinson’s disease [ 187 ]. For peroxiredoxins, little data is available, but elevated levels of several isoforms were measured in plasma of individuals with T2D [ 267 ], and prevention of apoptosis of pancreatic-beta cells was reported [ 272 ].…”

Section: Markers Of Os Relation To Disease and Practical Aspectsmentioning

confidence: 92%

Common and Novel Markers for Measuring Inflammation and Oxidative Stress Ex Vivo in Research and Clinical Practice—Which to Use Regarding Disease Outcomes?

Menzel¹,

Samouda

Dohet³

et al. 2021

Antioxidants

View full text Add to dashboard Cite

Many chronic conditions such as cancer, chronic obstructive pulmonary disease, type-2 diabetes, obesity, peripheral/coronary artery disease and auto-immune diseases are associated with low-grade inflammation. Closely related to inflammation is oxidative stress (OS), which can be either causal or secondary to inflammation. While a low level of OS is physiological, chronically increased OS is deleterious. Therefore, valid biomarkers of these signalling pathways may enable detection and following progression of OS/inflammation as well as to evaluate treatment efficacy. Such biomarkers should be stable and obtainable through non-invasive methods and their determination should be affordable and easy. The most frequently used inflammatory markers include acute-phase proteins, essentially CRP, serum amyloid A, fibrinogen and procalcitonin, and cytokines, predominantly TNFα, interleukins 1β, 6, 8, 10 and 12 and their receptors and IFNγ. Some cytokines appear to be disease-specific. Conversely, OS—being ubiquitous—and its biomarkers appear less disease or tissue-specific. These include lipid peroxidation products, e.g., F2-isoprostanes and malondialdehyde, DNA breakdown products (e.g., 8-OH-dG), protein adducts (e.g., carbonylated proteins), or antioxidant status. More novel markers include also –omics related ones, as well as non-invasive, questionnaire-based measures, such as the dietary inflammatory-index (DII), but their link to biological responses may be variable. Nevertheless, many of these markers have been clearly related to a number of diseases. However, their use in clinical practice is often limited, due to lacking analytical or clinical validation, or technical challenges. In this review, we strive to highlight frequently employed and useful markers of inflammation-related OS, including novel promising markers.

show abstract

Section: Markers Of Os Relation To Disease and Practical Aspectsmentioning

confidence: 92%

Common and Novel Markers for Measuring Inflammation and Oxidative Stress Ex Vivo in Research and Clinical Practice—Which to Use Regarding Disease Outcomes?

Menzel¹,

Samouda

Dohet³

et al. 2021

Antioxidants

View full text Add to dashboard Cite

show abstract

“…In addition to the dysregulation of blood oxidative stress markers in patients with HD found in this study, other meta-analyses also showed significant associations between AD, PD, ALS, and blood oxidative stress markers. Similar to HD, blood levels of MDA and 8-OHdG were elevated in patients with AD, PD, and ASL [ 7 – 10 , 38 ]. In contrast, in AD patients, GPx activity tended to decrease in plasma or serum [ 9 ]; in PD patients, GPx activity showed no significant differences, and GSH was significantly decreased when compared with controls [ 8 ].…”

Section: Discussionmentioning

confidence: 99%

Blood Oxidative Stress Marker Aberrations in Patients with Huntington’s Disease: A Meta-Analysis Study

Tang

Liu

Xiao

et al. 2020

Oxidative Medicine and Cellular Longevity

View full text Add to dashboard Cite

Huntington’s disease (HD) is a hereditary autosomal dominant neurodegenerative disease. Although studies have shown that blood oxidative stress markers are dysregulated in HD patients, clinical data on the blood oxidative stress markers of HD patients is inconsistent. To better understand the pathogenesis of HD, we performed a systematic review and meta-analysis of blood oxidative stress markers in HD patients and healthy control (HC) subjects. A database search from PubMed and Web of Science identified 12 studies with 375 HD patients and 447 HC subjects in this meta-analysis. A random-effects meta-analysis showed that blood lipid peroxidation products (Hedges’ g=0.883, 95%CI=0.637 to 1.130, p<0.001), 8-hydroxyguanosine (Hedges’ g=1.727, 95%CI=0.489 to 2.965, p=0.006) levels, and the activity of glutathione peroxidase (Hedges’ g=2.026, 95%CI=0.570 to 3.482, p=0.006) were significantly increased in HD patients compared to controls. In contrast, reduced glutathione levels were lower in HD patients than in controls (Hedges’ g=−0.611, 95%CI=−1.016 to−0.207, p=0.003). However, blood superoxide dismutase, cholesterol, high-density lipoproteins, low-density lipoproteins, and triglycerides did not show significant differences between cases and controls. Taken together, this study clarified the associations between blood oxidative stress markers and HD, supporting the clinical evidence that HD is accompanied by increased oxidative stress.

show abstract

“…Because most molecular oxygen is utilized by mitochondria for ETC activity (and is reduced to water), mitochondria are particularly susceptible to OS. OS damage has been described in ALS [ 74 , 75 ], AD [ 31 , 35 , 44 , 45 , 50 , 52 , 53 , 55 , 76 , 77 , 78 , 79 , 80 , 81 , 82 , 83 , 84 , 85 , 86 , 87 , 88 , 89 ], and PD [ 24 , 36 , 53 , 55 , 56 , 57 , 60 , 62 , 63 , 64 , 65 , 66 , 67 , 71 , 77 , 90 , 91 , 92 , 93 , 94 , 95 , 96 , 97 ] tissues and models.…”

Section: Oxidative Phosphorylation (Oxphos) Alterations In Nddsmentioning

confidence: 99%

Energy, Entropy and Quantum Tunneling of Protons and Electrons in Brain Mitochondria: Relation to Mitochondrial Impairment in Aging-Related Human Brain Diseases and Therapeutic Measures

Bennett

Onyango

2021

Biomedicines

View full text Add to dashboard Cite

Adult human brains consume a disproportionate amount of energy substrates (2–3% of body weight; 20–25% of total glucose and oxygen). Adenosine triphosphate (ATP) is a universal energy currency in brains and is produced by oxidative phosphorylation (OXPHOS) using ATP synthase, a nano-rotor powered by the proton gradient generated from proton-coupled electron transfer (PCET) in the multi-complex electron transport chain (ETC). ETC catalysis rates are reduced in brains from humans with neurodegenerative diseases (NDDs). Declines of ETC function in NDDs may result from combinations of nitrative stress (NS)–oxidative stress (OS) damage; mitochondrial and/or nuclear genomic mutations of ETC/OXPHOS genes; epigenetic modifications of ETC/OXPHOS genes; or defects in importation or assembly of ETC/OXPHOS proteins or complexes, respectively; or alterations in mitochondrial dynamics (fusion, fission, mitophagy). Substantial free energy is gained by direct O2-mediated oxidation of NADH. Traditional ETC mechanisms require separation between O2 and electrons flowing from NADH/FADH2 through the ETC. Quantum tunneling of electrons and much larger protons may facilitate this separation. Neuronal death may be viewed as a local increase in entropy requiring constant energy input to avoid. The ATP requirement of the brain may partially be used for avoidance of local entropy increase. Mitochondrial therapeutics seeks to correct deficiencies in ETC and OXPHOS.

show abstract

Oxidative stress-related biomarkers in Parkinson’s disease: A systematic review and meta-analysis

Cited by 22 publications

References 24 publications

Common and Novel Markers for Measuring Inflammation and Oxidative Stress Ex Vivo in Research and Clinical Practice—Which to Use Regarding Disease Outcomes?

Common and Novel Markers for Measuring Inflammation and Oxidative Stress Ex Vivo in Research and Clinical Practice—Which to Use Regarding Disease Outcomes?

Blood Oxidative Stress Marker Aberrations in Patients with Huntington’s Disease: A Meta-Analysis Study

Energy, Entropy and Quantum Tunneling of Protons and Electrons in Brain Mitochondria: Relation to Mitochondrial Impairment in Aging-Related Human Brain Diseases and Therapeutic Measures

Contact Info

Product

Resources

About