Analysis of the Operational Costs of Using Rapid Syphilis Tests for the Detection of Maternal Syphilis in Bolivia and Mozambique

Levin, Carol; Steele, Matt; Atherly, Deborah; García, Sandra G.; Tinajeros, Freddy; Revollo, Rita; Richmond, Kara; Dı́az-Olavarrieta, Claudia; Martin, Thomas E.; Floriano, Florência; Massango, Isabel; Gloyd, Stephen

doi:10.1097/01.olq.0000245986.62775.b6

Cited by 21 publications

(19 citation statements)

References 4 publications

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“…Previously published costs per woman screened with RSTs vary between $1.25 and $4.87 depending on prevalence rates, outcome probabilities used, and costs included in the analysis [29][30][31][32]. Our finding that RST costs for testing and treatment are lower than those for RPR is unique; previous studies have reported RST costs per woman screened to be $0.17 -$1.07 higher than those for RPR.…”

Section: Cost Of Screeningmentioning

confidence: 60%

The costs of accessible quality assured syphilis diagnostics: informing quality systems for rapid syphilis tests in a Tanzanian setting

Sweeney

Mosha

Terris‐Prestholt

et al. 2013

Health Policy and Planning

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Our results suggest that rapid syphilis diagnostics are very inexpensive in this setting and can overcome some critical barriers to ensuring universal access to syphilis testing and treatment. The additional costs for implementation of a quality system were found to be relatively small, and could be reduced through alterations to the programme design. Given the potential for a quality system to improve quality of diagnosis and care, we recommend that QA activities be incorporated into RST roll-out.

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Section: Cost Of Screeningmentioning

confidence: 60%

The costs of accessible quality assured syphilis diagnostics: informing quality systems for rapid syphilis tests in a Tanzanian setting

Sweeney

Mosha

Terris‐Prestholt

et al. 2013

Health Policy and Planning

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“…A recent internet search of the terms “treponemal test kit” showed that these tests currently retail for US$0.20–US$0.50 per unit [27]. However, in order to account for additional equipment that may be required over and above what is contained in a test kit (e.g., gloves), we used the low end of the historical range in our model (e.g., US$0.74) [28]. Similarly, the cost of a single dose of benzathine penicillin injection, excluding the cost of administration, has been reported to be in the range of US$0.77–US$1.92, and we used the higher estimate of that range (US$1.92) [7].…”

Section: Methodsmentioning

confidence: 99%

Antenatal Syphilis Screening Using Point-of-Care Testing in Sub-Saharan African Countries: A Cost-Effectiveness Analysis

et al. 2013

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“…Available data on the antenatal cost-effectiveness of POCT show that the ICS TT tests are cost-effective for the detection of maternal syphilis in low-resource settings compared to either standard 2-test algorithms (i.e., NTT followed by TT) or a NTT alone (65)(66)(67). Owusu-Edesei and colleagues recently reported that a screening strategy employing an ICS TT cost less than a dual-POCT (TT and NTT) strategy in a high-prevalence setting but that the dual-POCT strategy may significantly reduce overtreatment (68).…”

Section: Poctmentioning

confidence: 99%

Recent Trends in the Serologic Diagnosis of Syphilis

Morshed

Singh

2014

Clin. Vaccine Immunol.

163

156

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bComplexities in the diagnosis of syphilis continue to challenge clinicians. While direct tests (e.g., microscopy or PCR) are helpful in early syphilis, the mainstay of diagnosis remains serologic tests. The traditional algorithm using a nontreponemal test (NTT) followed by a treponemal test (TT) remains the standard in many parts of the world. More recently, the ability to automate the TT has led to the increasingly widespread use of reverse algorithms using treponemal enzyme immunoassays (EIAs). Rapid, point-of-care TTs are in widespread use in developing countries because of low cost, ease of use, and reasonable performance. However, none of the current diagnostic algorithms are able to distinguish current from previously treated infections. In addition, the reversal of traditional syphilis algorithms has led to uncertainty in the clinical management of patients. The interpretation of syphilis tests is further complicated by the lack of a reliable gold standard for syphilis diagnostics, and the newer tests can result in false-positive reactions similar to those seen with older tests. Little progress has been made in the area of serologic diagnostics for congenital syphilis, which requires assessment of maternal treatment and serologic response as well as clinical and laboratory investigation of the neonate for appropriate management. The diagnosis of neurosyphilis continues to require the collection of cerebrospinal fluid for a combination of NTT and TT, and, while newer treponemal EIAs look promising, more studies are needed to confirm their utility. This article reviews current tests and discusses current controversies in syphilis diagnosis, with a focus on serologic tests.

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Analysis of the Operational Costs of Using Rapid Syphilis Tests for the Detection of Maternal Syphilis in Bolivia and Mozambique

Abstract: It is feasible to introduce rapid syphilis testing in settings without laboratory services at a small incremental cost per woman screened. In settings with laboratories, the cost of ICS is similar to that of RPR.

Cited by 21 publications

References 4 publications

The costs of accessible quality assured syphilis diagnostics: informing quality systems for rapid syphilis tests in a Tanzanian setting

The costs of accessible quality assured syphilis diagnostics: informing quality systems for rapid syphilis tests in a Tanzanian setting

Antenatal Syphilis Screening Using Point-of-Care Testing in Sub-Saharan African Countries: A Cost-Effectiveness Analysis

Recent Trends in the Serologic Diagnosis of Syphilis

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