Analysis of the interrelation between immune factors and inflammatory markers, and the course of chronic heart failiure in patients with rheumathoid arthritis

Ankudinov, A.S.; Калягин, Алексей Николаевич

doi:10.18087/cardio.2495

Cited by 2 publications

(1 citation statement)

References 20 publications

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“…Однако существует ряд патологий, наличие которых у пациентов, на первый взгляд, остается незамеченным для врача, что соответственно не учитывается при подборе терапии. Из наиболее активно изучаемых ассоциаций стоит выделить заболевания опорно-двигательного аппарата, в частности ревматоидный артрит (РА) [6]. Роль системного воспаления обсуждается не только в качестве фактора, ухудшающего течение ССЗ, но и как причины, их вызывающей.…”

Section: Introductionunclassified

Analysis of the relationship between systemic inflammation and diastolic dysfunction in patients with heart failure and rheumatoid arthritis

Ankudinov¹,

Калягин²

2020

Cardiovasc Ther Prev

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Aim. To study the relationship of the systemic inflammation with the morphological and functional myocardial parameters in patients with heart failure (HF) due to hypertension and coronary artery disease in combination with rheumatoid arthritis (RA).Material and methods. The study included 57 women with NYHA class I-II HF. Patients were divided into two comparable groups: group 1 (n=31) — patients with HF and seropositive RA (Steinbrocker X-ray stage I-III); group 2 (n=26) — HF patients without RA.Results. A comparative analysis of morphological and functional parameters did not reveal significant differences: left ventricular ejection fraction in groups 1 and 2 were 51,06±5,6% and 51,6±6,4%, respectively (p=0,7); the ratio of peak velocity blood flow in early diastole to peak velocity flow in late diastole (E/A) was 0,9±0,1 and 0,8±0,1, respectively (p=0,7). For other echocardiographic parameters, differences were also not detected (p>0,05). Nevertheless, significant regression model was created between the RA activity score (DAS28), rheumatoid factor, and E/A was created: R=0,5; R2 =0,3; F=2,6; p=0,04.Conclusion. As a result of the study, significant direct moderate correlation of the RA activity score (DAS28) with E/A ratio was revealed in the group of patients with HF and RA. The data obtained may indicate an unfavorable prognosis of HF with an increase in RA activity.

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Section: Introductionunclassified

Analysis of the relationship between systemic inflammation and diastolic dysfunction in patients with heart failure and rheumatoid arthritis

Ankudinov¹,

Калягин²

2020

Cardiovasc Ther Prev

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Pentraxin-3 – a promising biological marker in heart failure: literature review

et al. 2022

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According to many studies, inflammation plays a very significant role in the pathogenesis of heart failure. Many studies have demonstrated an increase in circulating levels of inflammatory markers and cytokines such as C-reactive protein, tumor necrosis factor-a (TNF-a), and interleukins. C-reactive protein is produced in the liver in response to stimulation by various cytokines, mainly interleukin-6, and is a member of the pentraxin superfamily. Pentraxin-3, which is a long pentraxin, has a C-terminal domain of pentraxin similar to the classic short pentraxins, but differs from them in the presence of an unrelated long N-terminal domain. Various cell types can produce pentraxin-3 when exposed to primary inflammatory signals such as interleukin-1, tumor necrosis (TNF-a), oxidized low density lipoprotein, and microbial fragments (eg, lipopolysaccharide, lipoarabinomannans). Data in experimental animal models have demonstrated that pentraxin-3 can play cardioprotective and atheroprotective roles through its influence on the inflammatory process. Pentraxin-3 has been studied in several clinical protocols as a potential biomarker for cardiovascular disease.

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Analysis of the interrelation between immune factors and inflammatory markers, and the course of chronic heart failiure in patients with rheumathoid arthritis

Cited by 2 publications

References 20 publications

Analysis of the relationship between systemic inflammation and diastolic dysfunction in patients with heart failure and rheumatoid arthritis

Analysis of the relationship between systemic inflammation and diastolic dysfunction in patients with heart failure and rheumatoid arthritis

Pentraxin-3 – a promising biological marker in heart failure: literature review

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