Analysis of the genetic divergence in Asian strains of ZIKA virus with reference to 2015-2016 outbreaks

Shrinet, Jatin; Agrawal, Aditi; Bhatnagar, Raj K.; Sunil, Sujatha

doi:10.2471/blt.16.176065

Cited by 8 publications

(9 citation statements)

References 33 publications

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“…The recombination signal represents a possible recombination change due to a segment substitution near the amino terminus of the polyprotein. Other putative recombination events have been described by WHO in a preprint [ 18 ], using the RDP4 tool to detect recombination[ 19 ]. Notably all these sequences in both analyses were African, not Asian.…”

Section: Resultsmentioning

confidence: 99%

Comprehensive Annotation of Mature Peptides and Genotypes for Zika Virus

et al. 2017

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The rapid spread of Zika virus (ZIKV) has caused much concern in the global health community, due in part to a link to fetal microcephaly and other neurological illnesses. While an increasing amount of ZIKV genomic sequence data is being generated, an understanding of the virus molecular biology is still greatly lacking. A significant step towards establishing ZIKV proteomics would be the compilation of all proteins produced by the virus, and the resultant virus genotypes. Here we report for the first time such data, using new computational methods for the annotation of mature peptide proteins, genotypes, and recombination events for all ZIKV genomes. The data is made publicly available through the Virus Pathogen Resource at www.viprbrc.org.

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Section: Resultsmentioning

confidence: 99%

Comprehensive Annotation of Mature Peptides and Genotypes for Zika Virus

et al. 2017

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“…ZIKV strains can be grouped into two major groups based on sequence similarities-African and Asian. 89 ZIKV was first isolated from a rhesus monkey in 1947 in the Zika forest in Uganda, and human cases of ZIKV were documented there and in other areas of East Africa beginning in the 1950s. 57 By the mid-1950s, ZIKV was found scattered throughout East and West Africa, India, and Southeast Asia.…”

Section: Box 1 a Brief History Of Zikv Strains And Infectionsmentioning

confidence: 99%

“…Multiple ZIKV isolates, especially those of the Asian group, exhibit evidence of rapid mutation, including adaptive changes for human infection. 57,89,93 Analyses of 50 currently circulating Asian strains (isolated from Micronesia as well as South and Central America) exhibit conserved variation when compared to African strains, especially within structural proteins and this may be linked to increased ZIKV virulence over the past 10 years. 89,94,95 For additional information about the diverging and myriad ZIKV strains, see also infected with a microcephaly-associated Asian ZIKV strain with other closely related flaviviruses (an African ZIKV and DENV) highlights the importance of apoptotic regulators and viral response genes.…”

Section: Box 1 a Brief History Of Zikv Strains And Infectionsmentioning

confidence: 99%

Potential mechanisms of Zika‐linked microcephaly

Merfeld

Ben-Avi

Kennon

et al. 2017

WIREs Developmental Biology

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A recent outbreak of Zika virus (ZIKV) in Brazil is associated with microcephaly in infants born of infected mothers. As this pandemic spreads, rapid scientific investigation is shedding new light on how prenatal infection with ZIKV causes microcephaly. In this analysis we provide an overview of both microcephaly and ZIKV, explore the connection between prenatal ZIKV infection and microcephaly, and highlight recent insights into how prenatal ZIKV infection depletes the pool of neural progenitors in the developing brain. WIREs Dev Biol 2017, 6:e273. doi: 10.1002/wdev.273For further resources related to this article, please visit the WIREs website.

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“…As Figure 1 B displays, the WebLogo representation of the newly predicted four ZGQ sequences shows that the guanine residues involved in the GQ formation are highly conserved among the different evaluated strains and the residues present in the loop region are mostly divergent. Because ZIKV is an RNA virus, it is prone to a higher mutation rate, 39 and thus, the conservation of these ZGQs across the isolates suggests functional importance associated with viral life cycle and pathogenesis. In addition, we have also identified highly conserved ZGQ sequence motifs in the viral anti-genomic (negative-sense) RNA ( Figure S1 ; Table S3 ).…”

Section: Resultsmentioning

confidence: 99%

Inhibition of Zika virus replication by G-quadruplex-binding ligands

Majee

Pattnaik

Sahoo

et al. 2021

Molecular Therapy - Nucleic Acids

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Zika virus (ZIKV), a mosquito-transmitted Flavivirus, emerged in the last decade causing serious diseases and affecting human health globally. Currently, no licensed vaccines or antivirals are available to combat ZIKV, although several vaccine candidates are in the pipeline. In recent years, the presence of non-canonical G-quadruplex (GQ) secondary structures in viral genomes has ignited significant attention as potential targets for antiviral strategy. In this study, we identified several novel conserved potential GQ structures by analyzing published ZIKV genome sequences using an in-house algorithm. Biophysical and biochemical analysis of the RNA sequences containing these potential GQ sequences suggested the existence of such structures in the ZIKV genomes. Studies with known GQ structure-binding and -stabilizing ligands such as Braco-19 and TMPyP4 provided support for this contention. The presence of these ligands in cell culture media led to significant inhibition of infectious ZIKV yield, as well as reduced viral genome replication and viral protein production. Overall, our results, for the first time, show that ZIKV replication can be inhibited by GQ structure-binding and -stabilizing compounds and suggest a new strategy against ZIKV infection mitigation and control.

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Analysis of the genetic divergence in Asian strains of ZIKA virus with reference to 2015-2016 outbreaks

Cited by 8 publications

References 33 publications

Comprehensive Annotation of Mature Peptides and Genotypes for Zika Virus

Comprehensive Annotation of Mature Peptides and Genotypes for Zika Virus

Potential mechanisms of Zika‐linked microcephaly

Inhibition of Zika virus replication by G-quadruplex-binding ligands

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