Analysis of the FGFR spatiotemporal expression pattern within the chicken scleral ossicle system

Kumar, Shruti; Franz‐Odendaal, Tamara A.

doi:10.1016/j.gep.2018.08.004

Cited by 6 publications

(5 citation statements)

References 45 publications

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“…Perhaps the comparison of these data corroborates the reports of questions about the endoskeletal function of the scleral ring 6 . The trapezoid shape observed in individual diaphanized SOs was similar to that described by Zhang et al 8 and Kumar & Franz‐Odendaal, 34 both in birds; however, it differed from the hourglass shape reported by Franz‐Odendaal & Hall 35 for lizards and turtles of diverse species. Such findings support the existence of morphological variation in different groups 7,31,32 …”

Section: Discussionsupporting

confidence: 87%

Morphobiometry of the scleral ossicle rings in Chelonia mydas sea turtles

Boyda-Andrade

Silva

Raposo

et al. 2023

Veterinary Ophthalmology

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ObjectiveScleral ossicle rings of reptiles have endoskeletal functions that are not completely understood. Moreover, descriptive reports on the anatomy of those rings are scarce. We tried to make an anatomical description that could contribute to a better understanding of their functions.Animal Studied and ProceduresWe quantified, histologically characterized and evaluated the morphobiometry of the scleral ossicles, and measured the aditus orbitae of 25 sea turtle (Chelonia mydas) heads.ResultsThe aditus orbitae represented about one‐third of the total head length and the mean area of the internal opening of each ring was up to 8.37% of the aditus orbitae area. The mean internal diameter of the rings (6.32 mm) was characteristic of scotopic species and the most frequent number of ossicles per ring varied between 11 and 12. Two new classifications were proposed for the ossicle types: plus‐Verzahnung (+V) and minus‐Verzahnung (‐V). The bone tissue revealed a lamellar arrangement typical of compact and resistant bones.ConclusionThe obtained data may be used to support and expand the understanding of functions, animal activity patterns, distinctions between taxa and taphonomic interpretations.

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Section: Discussionsupporting

confidence: 87%

Morphobiometry of the scleral ossicle rings in Chelonia mydas sea turtles

Boyda-Andrade

Silva

Raposo

et al. 2023

Veterinary Ophthalmology

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“…Supporting evidence for the involvement of the above signaling molecules has been obtained over the past several decades, for both osteogenic and chondrogenic condensations. BMP and fibroblast growth factor ( FGF ) are potential inductive factors in the chicken scleral ossicle system [31,32,33,34]. During the onset of scleral ossicle induction at HH35, BMP2 was localized to the conjunctival epithelium and upon inhibition by Noggin bead implantation, a gap in the scleral ossicle ring where the bead had been implanted was found [33].…”

Section: Epithelial–mesenchymal Induction: When Where and Howmentioning

confidence: 99%

The Forgotten Skeletogenic Condensations: A Comparison of Early Skeletal Development Amongst Vertebrates

Giffin

Gaitor

Franz‐Odendaal

2019

JDB

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The development of a skeletogenic condensation is perhaps the most critical yet considerably overlooked stage of skeletogenesis. Described in this comprehensive review are the mechanisms that facilitate skeletogenic condensation formation, growth, and maintenance to allow for overt differentiation into a skeletal element. This review discusses the current knowledge of gene regulation and characterization of skeletogenic condensations in the chicken, mouse, zebrafish, and other developmental models. We limited our scope to condensations that give rise to the bones and cartilages of the vertebrate skeleton, with a particular focus on craniofacial and limb bud regions. While many of the skeletogenic processes are similar among vertebrate lineages, differences are apparent in the site and timing of the initial epithelial–mesenchymal interactions as well as in whether the condensation has an osteogenic or chondrogenic fate, both within and among species. Further comparative studies are needed to clarify and broaden the existing knowledge of this intricate phenomenon.

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“…FGFs are essential factors for www.nature.com/scientificreports/ ocular development during both prenatal and postnatal periods. FGFRs are well known to be expressed in the mammalian and avian sclera 22,23 . Thus, FGFs are thought to be involved in the axial growth of ocular dimensions.…”

Section: Discussionmentioning

confidence: 99%

Ocular biometric features of pediatric patients with fibroblast growth factor receptor-related syndromic craniosynostosis

Lee

Chung

et al. 2021

Sci Rep

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Ametropia is reported as a common ophthalmic manifestation in craniosynostosis. We retrospectively compared childhood refractive error and ocular biometric features of fibroblast growth factor receptor (FGFR)-related syndromic craniosynostosis patients with those of non-syndromic craniosynostosis and control subjects. Thirty-six eyes (18 patients) with FGFR-related syndromic craniosynostosis, 76 eyes (38 patients) with non-syndromic craniosynostosis, and 114 eyes (57 patients) of intermittent exotropes were included in the analysis. Mean age at examination was 7.82 ± 2.51 (range, 4–16) years and mean spherical equivalent was -0.09 ± 1.46 Diopter. Mean age and refractive error were not different between groups, but syndromic craniosynostosis patients had significantly longer axial length, lower corneal power, and lower lens power than other groups (p < 0.01, p < 0.01, and p < 0.01, respectively). Axial length was positively correlated and keratometry and lens power were negatively correlated with age in non-syndromic craniosynostosis and controls, while these correlations between age and ocular biometric parameters were not present in the FGFR-related syndromic craniosynostosis. In conclusion, ocular biometric parameters in FGFR-related syndromic craniosynostosis differed from those of non-syndromic craniosynostosis and age-matched controls, and did not show the relations with age, suggesting this cohort may have abnormal refractive growth.

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Analysis of the FGFR spatiotemporal expression pattern within the chicken scleral ossicle system

Cited by 6 publications

References 45 publications

Morphobiometry of the scleral ossicle rings in Chelonia mydas sea turtles

Morphobiometry of the scleral ossicle rings in Chelonia mydas sea turtles

The Forgotten Skeletogenic Condensations: A Comparison of Early Skeletal Development Amongst Vertebrates

Ocular biometric features of pediatric patients with fibroblast growth factor receptor-related syndromic craniosynostosis

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