Analysis of the expression of immunoglobulins throughout lactation suggests two periods of immune transfer in the tammar wallaby (Macropus eugenii)

Daly, Kerry A.; Digby, Matthew R.; Lefèvre, Christophe; Mailer, Sonia; Thomson, Peter; Nicholas, Kevin R.; Williamson, Peter

doi:10.1016/j.vetimm.2007.07.008

Cited by 50 publications

(42 citation statements)

References 69 publications

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“…Ingested antibodies provide the young not only immediate immunity, but also long term resistance against certain infections (Telemo and Hanson, 1996). In marsupials, a microarray study in the tammar wallaby and transcriptome analysis in the Tasmanian devil both showed that all four marsupial Ig isotypes (IgA, IgG, IgE, and IgM) are expressed in the milk (Daly et al, 2007; Hewavisenti et al, 2016). In the tammar wallaby, milk Ig expression exhibits two peak periods, with the first period occurring around parturition and the second around the end of phase 2 of lactation (Daly et al, 2007).…”

Section: Protection Through the Milkmentioning

confidence: 99%

Antimicrobial Protection of Marsupial Pouch Young

Cheng

Belov

2017

Front. Microbiol.

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Marsupials diverged from eutherian mammals about 148 million years ago and represent a unique lineage of mammals with distinctive morphological and reproductive characteristics. Marsupials have significantly shorter gestation periods than eutherians. Pregnancy typically ranges from 15 to 35 days, with young being born at a very early developmental stage and lacking differentiated lymphoid tissues and mature effector cells. Recent microbiome studies of the marsupial pouch revealed that marsupial young can face intense microbial challenges after birth, as the pouch contains a broad range of Gram-positive and Gram-negative bacteria. Antimicrobials are believed to play a significant role in the immune protection of marsupial newborns during their pouch life. The skin of the post-reproductive pouch secretes antimicrobial lysozyme and dermcidin, which may contribute to the decreased density of certain bacteria in the pouch. A range of antimicrobial agents, such as immunoglobulins, lysozyme, transferrin, and cathelicidins, have been identified in marsupial milk. Antimicrobial assays have revealed that marsupial cathelicidins have broad-spectrum activity against a variety of bacteria and fungi, including several multi-drug resistant strains. In this article, we will review the action mechanisms of these antimicrobial compounds and discuss how they protect marsupial newborns from potentially pathogenic bacteria inside the pouch. We will also discuss the potential of marsupial antimicrobial compounds as a source of novel antibiotics.

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Section: Protection Through the Milkmentioning

confidence: 99%

Antimicrobial Protection of Marsupial Pouch Young

Cheng

Belov

2017

Front. Microbiol.

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“…These include polymeric immunoglobulins, transferrin, lysozyme, a-lactalbumin, complement factors, CCL28, cathelicidin, and leukocytes. [40][41][42][43][44][45][46] Furthermore, concentrations of many of those agents change as lactation proceeds. [40][41][42][43][44][45][46] In addition, the immunological functions of the metatherian mammary gland are crucial to neonatal survival because marsupial young do not develop adult immune responses until just before detaching from a teat and leaving the pouch.…”

Section: Metatheriansmentioning

confidence: 99%

Evolution of Immune Functions of the Mammary Gland and Protection of the Infant

Goldman

2012

Breastfeeding Medicine

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The evolution of immunological agents in milk is intertwined with the general aspects of the evolution of the mammary gland. In that respect, mammalian precursors emerged from basal amniotes some 300 million years ago. In contrast to the predominant dinosaurs, proto-mammals possessed a glandular skin. A secondary palate in the roof of the mouth that directed airflow from the nostrils to the oropharynx and thus allowed mammals to ingest and breathe simultaneously first appeared in cynodonts 230 million years ago. This set the stage for mammalian newborns to nurse from the future mammary gland. Interplays between environmental and genetic changes shaped mammalian evolution including the mammary gland from dermal glands some 160 millions of years ago. It is likely that secretions from early mammary glands provided nutrients and immunological agents for the infant. Natural selection culminated in milks uniquely suited to nourish and protect infants of each species. In human milk, antimicrobial, anti-inflammatory, and immunoregulatory agents and living leukocytes are qualitatively or quantitatively different from those in other mammalian milks. Those in human milk compensate for developmental delays in the immunological system of the recipient infant. Consequently, the immune system in human milk provided by evolution is much of the basis for encouraging breastfeeding for human infants.

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“…ncbi.nlm.nih.gov) using common brushtail possum ( Trichosurus vulpecula ) TRA @ (AF133097) and TRB @ (AF133098) sequences. Overgos from Ig heavy and light chain genes were designed from previously characterised Ig heavy chain constant genes and light chain genes in the tammar wallaby [Daly et al, 2007]. Overgos used to screen the tammar wallaby BAC library are listed in table 1 .…”

Section: Overgo Designmentioning

confidence: 99%

“…Although TCR and Ig genes have previously been isolated in the tammar wallaby [Zuccolotto et al, 2000;Harrison et al, 2003;Parra et al, 2006Parra et al, , 2007Daly et al, 2007], their location within the tammar wallaby genome is unknown. Here we have isolated tammar wallaby bacterial artificial chromosomes (BACs) containing TCR genes, TRA @ /TRD @ , TRB @ , TRG @ and TCRM and BACs containing the Ig heavy chain gene ( IGH @ ) and light chain genes ( IGL @ and IGK @ ) and physically mapped these to chromosomes in the tammar wallaby.…”

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confidence: 99%

Physical Mapping of Immune Genes in the Tammar Wallaby <i>(Macropus eugenii)</i>

Sanderson

Belov

Deakin

2009

Cytogenet Genome Res

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The tammar wallaby (Macropus eugenii) is a model marsupial that has recently had its genome sequenced to a depth of 2-fold coverage. Although this is a great resource for comparative genomic studies, information on gene location is essential if this resource is to be used to its full potential. In this study, tammar wallaby bacterial artificial chromosomes (BACs) containing key immune genes were isolated from the tammar wallaby BAC library. BACs containing T cell receptor (TCR) and immunoglobulin (Ig) genes were physically mapped using fluorescence in situ hybridisation (FISH) to tammar wallaby chromosomes. Congruence between the locations of these immune genes in the tammar wallaby genome, with those predicted from chromosome painting data, highlights the conservation of genomic context of these important immune genes in marsupials. The isolation and mapping of these key immune genes in the tammar wallaby will aid in the assembly of the recently sequenced light coverage genome and assignment of sequence to chromosomes.

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Analysis of the expression of immunoglobulins throughout lactation suggests two periods of immune transfer in the tammar wallaby (Macropus eugenii)

Cited by 50 publications

References 69 publications

Antimicrobial Protection of Marsupial Pouch Young

Antimicrobial Protection of Marsupial Pouch Young

Evolution of Immune Functions of the Mammary Gland and Protection of the Infant

Physical Mapping of Immune Genes in the Tammar Wallaby <i>(Macropus eugenii)</i>

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