Analysis of the expression of HMGB-1, CXCL16, miRNA-30a, and TGF-β1 in primary nephritic syndrome patients and its significance

Wang, W J; Qu, Xiaoyan; Xi, Yu; Lv, Wen; Yu, Hongxiang

doi:10.4238/2015.august.19.17

Cited by 3 publications

(3 citation statements)

References 22 publications

(21 reference statements)

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“…21 Likewise, in children with NS, before starting therapy, GR expression was decreased in PBMC samples with initial SRNS. 23 While, in the steroidresponsive NS cases, increased levels of glomerular and T lymphocytes' GRs were observed in comparison to steroidresistant patients. 14,24 Similar to children, in adult with minimal change disease (MCD), decreased glomerular GR expression was observed in delayed responders than early responders.…”

Section: Discussionmentioning

confidence: 91%

“…In children with idiopathic NS, decreased GR expression was observed in the T lymphocytes of late responders compared to the controls and early responders 21 . Likewise, in children with NS, before starting therapy, GR expression was decreased in PBMC samples with initial SRNS 23 . While, in the steroid‐responsive NS cases, increased levels of glomerular and T lymphocytes' GRs were observed in comparison to steroid‐resistant patients 14,24 .…”

Section: Discussionmentioning

confidence: 94%

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Glucocorticoid receptors and their upstream epigenetic regulators in adults with steroid‐resistant nephrotic syndrome

et al. 2020

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Steroid-resistant nephrotic syndrome (SRNS) is a clinical challenge with variable clinical outcomes. In patients with SRNS, unsuccessful anti-inflammatory and anti-proteinuric effects of steroids lead to end-stage renal disease (ESRD). Our objective was to define the expression pattern of the glucocorticoid receptors (GR) α and β and their epigenetic regulators (miR-24, miR-30a, and miR-370) in a group of adults with SRNS. In this regard, sixty primary NS patients with focal segmental glomerulosclerosis (FSGS, N = 30) and membranous glomerulonephritis (MGN, N = 30) and also healthy volunteers (N = 24) were enrolled. Real-time PCR was performed to evaluate the expression levels of the aforementioned genes in peripheral blood mononuclear cell (PBMC) samples.

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Section: Discussionmentioning

confidence: 91%

Section: Discussionmentioning

confidence: 94%

Glucocorticoid receptors and their upstream epigenetic regulators in adults with steroid‐resistant nephrotic syndrome

et al. 2020

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“… 19 Among 56 patients with primary nephritic syndromes, as compared with 50 healthy subjects, serum High Mobility Group Box 1 (HMGB-1), Chemokine [C-X-C motif ] ligand 6 (CXCL16), miRNA-30a and urinary Transforming Growth Factor Beta1 (TGF-ß1) were highly expressed in the former and correlated with the pathognomic biochemical alterations of nephrosis and were speculated to play important roles in the pathogenesis and development of these disorders. 20 …”

Section: Introductionmentioning

confidence: 99%

Can microRNA profiles predict corticosteroid responsiveness in childhood nephrotic syndrome? A study protocol

Patnaik¹,

Kumar²,

Yadav³

et al. 2018

bmjpo

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IntroductionIn last few years, several studies have revealed the remarkable stability of extracellular microRNAs (miRNAs) circulating in the blood or excreted in the urine and underscored their key importance as biomarkers of certain diseases. Since miRNA in urinary sediment is relatively stable and easily quantified, it has the potential to be developed as a biomarker for disease diagnosis and monitoring. Identification of serum and urinary levels of certain miRNAs may assist in the diagnosis and assessment of disease activity in patients with nephrotic syndrome (NS). The global expression profile of miRNAs in childhood NS in Indian population remains unknown. Hence, further research is warranted in this area. This study seeks to prospectively evaluate whether a multipronged multiomics approach concentrating on microRNA expression profiles in children with NS vis-a-vis normal healthy children is discriminant enough to predict steroid responsiveness in childhood NS.Methods and analysisIn this prospective multicentric cohort study, subjects will be recruited from general paediatric and paediatric nephrology outpatient departments (OPDs) in tertiary care level referral hospitals. Age-matched and sex-matched healthy individuals with normal renal function (as assessed by normal serum creatinine and normal ultrasound of kidneys, ureter and bladder) in 1:1 ratio between study and control groups will be recruited from among the healthy siblings of children presenting to the OPDs. Differential microRNA expression profiles in urine and serum samples of children with steroid-sensitive NS (SSNS) and steroid-resistant NS (SRNS) with healthy children will be compared in a two-phased manner: a biomarker discovery phase involving pooled samples across SSNS, SRNS and healthy siblings analysed in triplicate using next-generation sequencing, slide microarray and quantitative reverse transcriptase PCR (qRT-PCR) arrays covering human miRNome followed by a validation phase with customised qRT-PCR primers based on the concordance in the discovery phase differential expression profiles and bioinformatics analysis.Ethics and disseminationThe study is funded after dueInstitutional Ethics Committee (IEC) clearance, and results will be available as open access.

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Urinary Biomarkers for Bladder Outlet Obstruction

Monastyrskaya

Burkhard

2017

Curr Bladder Dysfunct Rep

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Analysis of the expression of HMGB-1, CXCL16, miRNA-30a, and TGF-β1 in primary nephritic syndrome patients and its significance

Cited by 3 publications

References 22 publications

Glucocorticoid receptors and their upstream epigenetic regulators in adults with steroid‐resistant nephrotic syndrome

Glucocorticoid receptors and their upstream epigenetic regulators in adults with steroid‐resistant nephrotic syndrome

Can microRNA profiles predict corticosteroid responsiveness in childhood nephrotic syndrome? A study protocol

Urinary Biomarkers for Bladder Outlet Obstruction

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