Analysis of the expression of neurokinin B, kisspeptin, and their cognate receptors NK3R and KISS1R in the human female genital tract

Roman, Antonio Cejudo; Pinto, Francisco M.; Dorta, I.; Almeida, Teresa; Hernández, Mariano; Illanes, Matilde; Tena‐Sempere, Manuel; Candenas, Luz

doi:10.1016/j.fertnstert.2012.02.021

Cited by 97 publications

(41 citation statements)

References 44 publications

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“…This is consistent with previous reports that the concentration of kisspeptin is seen to increase during the pre‐ovulatory period and the luteal phase during the menstrual cycle . It is known that kisspeptin is expressed in the ovarian granulosa‐lutein cells and theca cells of growing follicles and the rise in plasma kisspeptin concentration coincides with the time when the expression of kisspeptin increases in the ovary. Although there are multiple expression sites of kisspeptin in the peripheral organs, the concentrations show a constant fluctuation in the short period of ovarian stimulation; thus, an increase in kisspeptin in the ovary accompanying follicular growth might contribute to an increase in plasma concentrations.…”

Section: Discussionsupporting

confidence: 92%

“…In contrast, recently it has been reported that kisspeptin is expressed in granulosa‐lutein cells and theca cells in the ovary . There are reports that, if a kisspeptin antagonist is locally administered to the ovary, delayed vaginal opening and a disorder of the estrous cycle occur, and that mice heterozygous for kisspeptin receptors are in the same state as premature ovarian failure .…”

Section: Introductionmentioning

confidence: 98%

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Intra‐follicular kisspeptin levels are related to oocyte maturation and gonadal hormones in patients who are undergoing assisted reproductive technology

Taniguchi

Kuwahara

Tachibana

et al. 2017

Reprod Medicine & Biology

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PurposeTo assess the kisspeptin concentrations in follicular fluid and their relationship with clinical outcomes during assisted reproductive technology.MethodsThirty‐nine patients who were aged 24‐40 years and underwent oocyte retrieval for in vitro fertilization/intracytoplasmic sperm injection participated in this study. In 65 follicular fluid samples that had been obtained from 30 patients and their blood samples, the kisspeptin levels were measured in order to investigate the correlations with their gonadal hormone levels. Venous blood samples were collected from 14 patients to investigate their plasma kisspeptin levels across different phases of assisted reproductive technology.ResultsThe follicular fluid kisspeptin level was significantly higher than that of the plasma level and was positively associated with the follicular fluid estradiol concentration and with the serum estradiol and number of mature oocytes. In the plasma, the maximum concentration of kisspeptin was observed on the day of ovum pick‐up and on the day of embryo transfer during ovarian stimulation for assisted reproductive technology.ConclusionKisspeptin was present in the follicular fluid and the plasma kisspeptin concentration was affected by ovarian stimulation. Kisspeptin appears to affect oocyte maturation and ovulation.

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Section: Discussionsupporting

confidence: 92%

Section: Introductionmentioning

confidence: 98%

Intra‐follicular kisspeptin levels are related to oocyte maturation and gonadal hormones in patients who are undergoing assisted reproductive technology

Taniguchi

Kuwahara

Tachibana

et al. 2017

Reprod Medicine & Biology

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“…The pituitary, which is vital in the control of metabolic homeostasis and reproduction, highly expresses Rfrp, GnIHR, Kiss1, and Kiss1r (Lee et al 1996, Muir et al 2001, Ohtaki et al 2001, Shahab et al 2005, Ubuka et al 2009b, Smith et al 2010a,b, Tsutsui et al 2010, Wahab et al 2011a, Cejudo Roman et al 2012, Irfan et al 2014.…”

Section: Kp and Gnih Signaling In Conditions Of Altered Energy Balancmentioning

confidence: 99%

The involvement of gonadotropin inhibitory hormone and kisspeptin in the metabolic regulation of reproduction

Wahab¹,

Shahab²,

Behr³

2015

Journal of Endocrinology

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Recently, kisspeptin (KP) and gonadotropin inhibitory hormone (GnIH), two counteracting neuropeptides, have been acknowledged as significant regulators of reproductive function. KP stimulates reproduction while GnIH inhibits it. These two neuropeptides seem to be pivotal for the modulation of reproductive activity in response to internal and external cues. It is well-documented that the current metabolic status of the body is closely linked to its reproductive output. However, how reproductive function is regulated by the body's energy status is less clear. Recent studies have suggested an active participation of hypothalamic KP and GnIH in the modulation of reproductive function according to available metabolic cues. Expression of KISS1, the KP encoding gene, is decreased while expression of RFRP (NPVF), the gene encoding GnIH, is increased in metabolic deficiency conditions. The lower levels of KP, as suggested by a decrease in KISS1 gene mRNA expression, during metabolic deficiency can be corrected by administration of exogenous KP, which leads to an increase in reproductive hormone levels. Likewise, administration of RF9, a GnIH receptor antagonist, can reverse the inhibitory effect of fasting on testosterone in monkeys. Together, it is likely that the integrated function of both these hypothalamic neuropeptides works as a reproductive output regulator in response to a change in metabolic status. In this review, we have summarized literature from nonprimate and primate studies that demonstrate the involvement of KP and GnIH in the metabolic regulation of reproduction.

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“…By acting through its G‐protein coupled receptor, Kiss1‐R, Kiss1 centrally stimulates pulsatile GnRH release (Funes et al., ; Seminara et al., ). Kiss1 and its receptor were also found in human and rat ovarian tissues, as well as in granulosa‐lutein cells in vitro (Cejudo Roman et al., ; Gaytan et al., ). Also, the presence of GnRH‐R transcripts was confirmed in ovarian follicles and corpus luteum (CL), for example in mouse (Torrealday, Lalioti, Guzeloglu‐Kayisli, & Seli, ) and human (Choi, Gilks, Auersperg, & Leung, ).…”

Section: Introductionmentioning

confidence: 98%

Expression of GnRH receptor in the canine corpus luteum, and luteal function following deslorelin acetate‐induced puberty delay

Kaya

Gram

Kowalewski

et al. 2017

Reprod Domestic Animals

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The goals of this study were as follows: (Experiment 1) to examine the basic capability of canine corpora lutea (CL) to respond to GnRH by assessing expression of gonadotropin-releasing hormone receptor (GnRH-R) in luteal samples collected throughout the luteal lifespan from non-pregnant dogs, and (Experiment 2) to investigate the effects of pre-pubertal application of the GnRH agonist deslorelin acetate on luteal function following the first oestrus. Mature CL were collected during the mid-luteal phase (days 30-45) from treated and control bitches. Transcript levels of several factors were determined: estrogen receptors (ESR1/ERα, ESR2/ERβ), progesterone (P4)-receptor (PGR), prolactin receptor (PRLR), PGE2-synthase (PTGES) and PGE2 receptors (PTGER2/EP2, PTGER4/EP4), vascular endothelial growth factor (VEGFA) and VEGF receptors (VEGFR1 and VEGFR2), cyclooxygenase 2 (COX2/PTGS2), steroidogenic acute regulatory protein (STAR) and 3β-hydroxysteroid dehydrogenase (3βHSD). Additionally, levels of Kisspeptin 1 (Kiss1) and its receptor (KISS1-R) were evaluated. Although generally low, GnRH-R expression was time dependent and was elevated during early dioestrus, with a significant decrease towards luteal regression. In deslorelin-treated and control dogs, its expression was either low or frequently below the detection limit. EP2 and VEGFR1 were higher in the treated group, which could be caused by a feedback mechanism after long-term suppression of reproductive activity. Despite large individual variations, 3βHSD was higher in the deslorelin-treated group. This, along with unchanged STAR expression, was apparently not mirrored in increased luteal functionality, because similar P4 levels were detected in both groups. Finally, the deslorelin-mediated long-term delay of puberty does not have negative carry-over effects on subsequent ovarian functionality in bitches.

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Analysis of the expression of neurokinin B, kisspeptin, and their cognate receptors NK3R and KISS1R in the human female genital tract

Cited by 97 publications

References 44 publications

Intra‐follicular kisspeptin levels are related to oocyte maturation and gonadal hormones in patients who are undergoing assisted reproductive technology

Intra‐follicular kisspeptin levels are related to oocyte maturation and gonadal hormones in patients who are undergoing assisted reproductive technology

The involvement of gonadotropin inhibitory hormone and kisspeptin in the metabolic regulation of reproduction

Expression of GnRH receptor in the canine corpus luteum, and luteal function following deslorelin acetate‐induced puberty delay

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