Analysis of the Evolution of Feline Parvovirus (FPV)

Battilani, Mara; Bassani, Milena; Forti, D; Morganti, L.

doi:10.1007/s11259-006-0046-4

Cited by 29 publications

(31 citation statements)

References 10 publications

(8 reference statements)

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“…10,18 The presence of this variant in cats may reflect the transfer of viruses from dogs, confirming the diffusion and evolution of virus variants of CPV-2 in nature. 4 In conclusion, the current study reports the detection of the 426 Glu variant of CPV in a domestic cat in Portugal. The pathogenicity of extant CPV strains in cats and the relative prevalence of CPV and FPV in cat populations is currently very limited.…”

Section: Research-article2014mentioning

confidence: 56%

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Canine parvovirus 2c infection in a cat with severe clinical disease

2014

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Abstract. Canine parvovirus 2 (CPV-2) is considered the main pathogen responsible for acute gastroenteritis in dogs, causing vomiting and hemorrhagic enteritis mainly. However, infection in cats by CPV variants causes clinical signs similar to Feline panleukopenia virus. The current study reports a case of CPV-2c in a domestic cat, in Portugal. The findings suggest that more surveys are needed to know the true prevalence and significance of cats in CPV epidemiology worldwide.

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Section: Research-article2014mentioning

confidence: 56%

“…3,22 These type infections could potentially facilitate recombinations and high genetic heterogeneity. 4 The current study reports a case of CPV-2c in a female cat with severe disease, in Portugal.…”

mentioning

confidence: 85%

Canine parvovirus 2c infection in a cat with severe clinical disease

2014

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“…Their genetic evolution has been associated with the intrinsic variability related to the single-stranded DNA conformation, as well as to the positive selection pressure related to the host immunity (Shackelton et al, 2005). Feline panleukopenia virus (FPLV) was identified at the beginning of the 20th century (Verge & Christoforoni, 1928), maintaining a certain degree of genetic stability (Battilani et al, 2006a). However, molecular studies have not been carried out for several decades: therefore the antigenic properties of the strains currently circulating are not well known.…”

Section: Introductionmentioning

confidence: 99%

Genetic analysis of feline panleukopenia viruses from cats with gastroenteritis

Decaro¹,

Desario²,

Miccolupo

et al. 2008

Journal of General Virology

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Thirty-nine parvovirus strains contained in faecal samples collected in Italy (n534) and UK (n55) from cats with feline panleukopenia were characterized at the molecular level. All viruses were proven to be true feline panleukopenia virus (FPLV) strains by a minor groove binder probe assay, which is able to discriminate between FPLV and the closely related canine parvovirus type 2. By using sequence analysis of the VP2 gene, it was found that the FPLV strains detected in Italy and UK were highly related to each other, with a nucleotide identity of 99.1-100 and 99.4-99.8 % among Italian and British strains, respectively, whereas the similarities between all the sequences analysed were 98.6-100 %. Eighty-eight variable positions were detected in the VP2 gene of the field and reference FPLV strains, most of which were singletons. Synonymous substitutions (n557) predominated over non-synonymous substitutions (n531), and the ratio between synonymous and non-synonymous substitutions (dN/dS) was 0.10, thus confirming that evolution of FPLV is driven by random genetic drift rather than by positive selection pressure. Some amino acid mutations in the VP2 protein affected sites that are thought to be responsible for antigenic and biological properties of the virus, but no clear patterns of segregation and genetic markers, were identified, confirming that FPLV is in evolutionary stasis.

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“…The original CPV-2 was rapidly replaced with a new antigenic type CPV-2a, CPV-2b in 1979-1984(Parrish et al, 1991 and finally, the newest strain of CPV-2c was detected in 2000 in Italy (Buonavoglia et al, 2001). In contrast with the original CPV-2; CPV-2a/2b/2c earned the ability to replicate in a cat host and could also induce the clinical disease (Mochizuki et al, 1993;Truyen et al, 1996;Ikeda et al, 2000;Battilani et al, 2006a;Muz et al, 2012;Decaro et al, 2008;2011). CPV-2 variants (2a, 2b, 2c) are able to bind with feline Transferrin receptors and enter into the cells (Ikeda et al, 2002;Hueffer and Parrish, 2003) Despite CPV, FPV is evolutionarily static and develops by random genetic drift (Decaro et al, 2008) whereas the mutation rate of CPV is much higher.…”

Section: Introductionmentioning

confidence: 99%

“…There are reports about the presence of two or more strains of parvovirus, simultaneously in one cat as a host (Battilani et al, 2006a;2013; that make cats a suitable host for evolution and genetic recombination of parvoviruses. Based on the authors' knowledge, no molecular study has been performed on parvoviruses which infect cats in Iran, Tehran and therefore, it was considered as the objective of this study.…”

Section: Introductionmentioning

confidence: 99%

Sequence Analysis of VP2 Gene of the Parvoviruses Isolated from Fecal Samples of Domestic Cats in Tehran, Iran

Jahanbin

Jamshidi

Madadgar

2017

American Journal of Animal and Veterinary Sciences

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Panleukopenia is a viral enteritis of high mortality rate in Feline population. It is caused by a small single-stranded DNA virus, belonging to the Family Parvoviridae, called Feline Panleukopenia Virus (FPV). Parvoviruses are capable of adapting to new hosts and can simply mutate like RNA viruses, resulting in the emergence of different strains with antigenic changes. Unlike the original Canine Parvovirus (CPV) type 2, the antigenic variants (CPV-2a, CPV-2b, CPV-2c) earned the ability to replicate in cat hosts either with clinical signs or without any symptoms. Cats may be able to shed Parvoviruses for a long time and can serve as an important reservoir. Co-infection with FPV and CPV-2 variants has been also reported. These characteristics make the cat an important host for Parvoviruses. Since no molecular study has reported on Parvoviruses infected cats in Iran, a decision was made to study these strains of Parvovirus. Twenty-eight fecal samples were collected from kittens under 6 months of age, both male and female and different breeds which had leukemia. PCR was performed on each sample and 26 samples tested positive for Parvoviruses. Randomly, the PCR products of eight samples were sequenced and their phylogenetic tree was generated. Analysis of the results revealed that all eight samples are FPV and it appears that FPV is more clonal than the CPV-2 variants in Iran. Amino acid residue 232 from the VP2 gene of FPVs has been changed from isoleucine to valine, which has only been reported in CPV-2 and its variants. It seems that some FPVs of Iran are changing to the CPV-2 variants. Hence, it is expected that in the future, the CPV-2 variants will be observed in cats.

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Analysis of the Evolution of Feline Parvovirus (FPV)

Cited by 29 publications

References 10 publications

Canine parvovirus 2c infection in a cat with severe clinical disease

Canine parvovirus 2c infection in a cat with severe clinical disease

Genetic analysis of feline panleukopenia viruses from cats with gastroenteritis

Sequence Analysis of VP2 Gene of the Parvoviruses Isolated from Fecal Samples of Domestic Cats in Tehran, Iran

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