Analysis of the domestic pharmaceutical market of anthelmintic medicines

Abstract

The problem of helminthiases is particularly relevant not only in veterinary medicine, but also in medical practice of mankind. Today, the spread of parasitic diseases concerns any country in the world, including countries with high living standards. The greatest danger is the fact that the vast majority of cases of the digestive system helminthiases is in children of the preschool and early school age. In all age groups of patients there is also a significant deterioration of the immune system and development of autoimmune diseases as a consequence of the disease. Aim. To analyze the range of anthelmintic medicines presented at the pharmaceutical market of Ukraine. Materials and methods. Distribution of anthelmintic medicines by their origin and dosage forms, as well as by price offers was studied at the level of the industrial area of Kharkiv and the Kharkiv region. The data processing was performed using the methods of economic and statistical analysis, and the results were processed using computer programs. Results and discussion. The domestic market of anthelmintic medicines offers 19 medicines on the basis of praziquantel, mebendazole, albendazole, piperazine, pyrantel, levamisole and one medicine in the form of a herbal tea-tansy flowers. Medicines of the Ukrainian production are only 36.8 %, while the most (63.2 %) of medicinal products comes from manufacturers of the UK, France and India. Anthelmintic medicines are presented in 3 dosage forms, among them coated tablets dominate. The analysis of price offers on the example of those that are available in Kharkiv and the Kharkiv region, taking into account the offers of internet pharmacies, showed their significant variation (from 2 to 1248). Among the medicines with albendazole as the active ingredient the greatest difference of price offers is typical for vormil in the form of coated tablets. Conclusions. It has been found that the existing range of anthelmintic medicines requires development and implementation of new domestic products in the industrial production. A particular attention should be paid to development of products based on the medicinal plant raw material.

Toxic action of substances from male fern Dryopteris filix-mas (L.) Schott (1834) on free-living soil nematode Caenorhabditis elegans Maupas (1900)

“…At present we have no sufficient scientific basis for use of plant-derived substances for treatment helminthiases of humans and animals. acethylcholine esterase inhibitors, agonists and antagonists of acethylcholine receptors [9,21]. Tansy Tanacetum vulgare, wormwood Artemisia absintium and some other plants using for helminthiases treatment contain thujone -antagonist of one of subtypes of γaminobutiric acid receptors [9,22].…”

“…acethylcholine esterase inhibitors, agonists and antagonists of acethylcholine receptors [9,21]. Tansy Tanacetum vulgare, wormwood Artemisia absintium and some other plants using for helminthiases treatment contain thujone -antagonist of one of subtypes of γaminobutiric acid receptors [9,22]. Valerenic acid containing in ground parts of Valeriana officinalis is agonist of serotonin receptors with high affinity to 5-HT5A receptor and low affinity to 5-HT2B receptor and serotonin transporter [23].…”

“…Folk medicine traditionally uses spermaphytes [9][10]. Higher sporophytes are used in folk medicine and ethnoveterinary more rarely, although medicinal qualities of ferns were known long ago [7,11].…”

Study of anthelmintic activity and acute toxicity of medicine of combined composition

“…As the range of anthelminthic medicines is represented by monodrugs [8], whereas in most cases it is recommended to combine several active pharmaceutical ingredients while etiotropic treatment to achieve a quick and complete elimination of pathogens from the patient's body [9], there were conducted the relevant studies on combination of albendazole and praziquantel in different ratios.…”

Nematicidal activity of menthol and its dithiophosphoric derivatives

“…One of the ways to solve this problem can be use of secondary plant metabolites and their derivatives [18]. In folk medicine, along with tansy, wormwood and elecampane, mint is used to treat helminthiasis [19].…”