Analysis of the diagnostic accuracy of the gamma interferon assay for detection of bovine tuberculosis in U.S. herds

Antognoli, M. C.; Remmenga, Marta D.; Bengtson, Steven D.; Clark, Halden J.; Orloski, Kathy A.; Gustafson, Lori; Scott, Aaron E.

doi:10.1016/j.prevetmed.2011.05.012

Cited by 20 publications

(20 citation statements)

References 12 publications

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“…Because AUC was greater than 0.7, MNDWI was able to distinguish seasonal wetlands and dry land with moderately good performance [37]. The error rate for the recognition of the two types of land was moderately low, with an error of 21.2%.…”

Section: Discussionmentioning

confidence: 97%

Evaluation of the Surface Water Distribution in North-Central Namibia Based on MODIS and AMSR Series

et al. 2014

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Semi-arid North-central Namibia has high potential for rice cultivation because large seasonal wetlands (oshana) form during the rainy season. Evaluating the distribution of surface water would reveal the area potentially suitable for rice cultivation. In this study, we detected the distribution of surface water with high spatial and temporal resolution by using two types of complementary satellite data: MODIS (MODerate-resolution Imaging Spectroradiometer) and AMSR-E (Advanced Microwave Scanning Radiometer-Earth Observing System), using AMSR2 after AMSR-E became unavailable. We combined the modified normalized-difference water index (MNDWI) from the MODIS data with the normalized-difference polarization index (NDPI) from the AMSR-E and AMSR2 data to determine the area of surface water. We developed a simple gap-filling method ("database unmixing") with the two indices, thereby providing daily 500-m-resolution MNDWI maps of north-central Namibia regardless of whether the sky was clear. Moreover, through receiver-operator characteristics (ROC) analysis, we determined the threshold MNDWI (−0.316) for wetlands. Using ROC analysis, MNDWI had moderate performance (the area under the ROC curve was 0.747), and the recognition error for seasonal wetlands and dry land was 21.2%. The threshold MNDWI let us calculate probability of water presence (1.6% of the study area).

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Section: Discussionmentioning

confidence: 97%

Evaluation of the Surface Water Distribution in North-Central Namibia Based on MODIS and AMSR Series

et al. 2014

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“…Under the single cutoff, CFT has a sensitivity of 84.9% and specificity of 89.2% (24). While the comparative cervical test (CCT) has a sensitivity of 74% and a specificity of 96%, the IGRA has a sensitivity of 83.9% and a specificity of 90.7% (25,26). It is important to note that a "one-sizefits-all" testing method is not appropriate for all regions, states, and countries, and that the available diagnostic methods do not reflect this.…”

Section: Discussionmentioning

confidence: 99%

Circulating Mycobacterium bovis Peptides and Host Response Proteins as Biomarkers for Unambiguous Detection of Subclinical Infection

et al. 2014

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e Bovine tuberculosis remains one of the most damaging diseases to agriculture, and there is also a concern for human spillover. A critical need exists for rapid, thorough, and inexpensive diagnostic methods capable of detecting and differentiating Mycobacterium bovis infection from other pathogenic and environmental mycobacteria at multiple surveillance levels. In a previous study, Seth et al. (PLoS One 4:e5478, 2009, doi:10.1371/journal.pone.0005478) identified 32 host peptides that specifically increased in the blood serum of M. bovis-infected animals). In the current study, 16 M. bovis proteins were discovered in the blood serum proteomics data sets. A large-scale validation analysis was undertaken for selected host and M. bovis proteins using a cattle serum repository containing M. bovis (n ‫؍‬ 128), Mycobacterium kansasii (n ‫؍‬ 10), and Mycobacterium avium subsp. paratuberculosis (n ‫؍‬ 10), cases exposed to M. bovis (n ‫؍‬ 424), and negative controls (n ‫؍‬ 38). Of the host biomarkers, vitamin D binding protein (VDBP) showed the greatest sensitivity and specificity for M. bovis detection. Circulating M. bovis proteins, specifically polyketide synthetase 5, detected M. bovis-infected cattle with little to no seroreactivity against M. kansasii-and M. avium subsp. paratuberculosis-infected animals. These data indicate that host and pathogen serum proteins can serve as reliable biomarkers for tracking M. bovis infection in animal populations.

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“…Among the advantages of the interferon based techniques over the intradermal tuberculin tests are less frequent handling of animals, objective numerical test results, and comparative response to two different antigens (Bezos et The major difference between previous surveys and the present report in relation to the supposed benefits of the use on Gamma interferon is that most of the above mentioned surveys were conducted under controlled experimental conditions and or in real field situations but with (Gormley et al 2013). Furthermore, Gamma interferon depends on the presence of viable lymphocytes in the blood sample collected in the field; careful handling of blood samples and timely transportation to the laboratories are critical to this test and are limitations of this diagnostic tool (Antognoli et al 2011), for this reason, celular viability must be determined whenever this methodoloy is used to asses infection satus on herds, in the present study Concanavalin-A was used to assess this issue. Due to the above mentioned limitations, specific cutoff lines for interferon based techniques for certain areas with particular low bTB prevalence should be considered (Faye et al 2011), as is the Chilean situation.…”

Section: Resultsmentioning

confidence: 74%

Comparison of common tests performance for Mycobacterium bovis infection diagnosis in low prevalence dairy cattle herds of southern Chile

Raffo

Monti

Salgado

2018

Austral j. vet. sci.

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ABSTRACT. The aim of the present study was to assess the performance of routinely used diagnostic tests to detect M. bovis infection in cattle populations with very low infection prevalence. A cross-sectional study was performed using 609 animals from 17 herds that were sampled for blood interferon, and tested with the caudal fold tuberculin test (CFT). It was planned that animals which showed CFT positive results were sent to the slaughterhouse for post mortem confirmation testing. However, not all the animals considered in the initial sampling were culled. Paired population proportions of positive results for the different diagnostic tools were compared. Apparent sensitivity and specificity was also estimated. Overall, intradermal tuberculin based diagnostics showed better performance in comparison to interferon based test, even though interferon was slightly more specific. From these results, it may be suggested that specific cut-off lines for interferon based techniques for certain areas with particular low bTB prevalence should be considered, as well as the modification of more specific antigens and the use of better combinations of PPDs if in vitro testing is intended must be taken into consideration. The uncertain role of interference bacteria that could be affecting the results of the in vitro analysis must be considered, and perhaps this could explain the apparent lack of consensus of the results obtained in Chile versus the ones obtained elsewhere. More studies must be performed in order to assess this issue.

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Analysis of the diagnostic accuracy of the gamma interferon assay for detection of bovine tuberculosis in U.S. herds

Cited by 20 publications

References 12 publications

Evaluation of the Surface Water Distribution in North-Central Namibia Based on MODIS and AMSR Series

Evaluation of the Surface Water Distribution in North-Central Namibia Based on MODIS and AMSR Series

Circulating Mycobacterium bovis Peptides and Host Response Proteins as Biomarkers for Unambiguous Detection of Subclinical Infection

Comparison of common tests performance for Mycobacterium bovis infection diagnosis in low prevalence dairy cattle herds of southern Chile

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