Analysis of the contribution of -5t/c polymorphism in the GP1BA gene to the development of ischemic stroke in young patients

Abstract

The impact of -5T/C polymorphism in the GP1BA gene on the risk of ischemic stroke (IS) was studied in patients younger than 50 years of age. Ninety-two patients (73 men and 19 women; mean age 42.6±6.7 years) with atherothrombotic, lacunar, and cryptogenic IS were examined on days 1-21 after its development. All the patients underwent brain magnetic resonance imaging or computed tomography, brachiocephalic artery duplex scanning, echocardiography, and laboratory studies (antiphospholipid antibodies, coagulogram and platelet aggregation, homocysteine, clinical and biochemical blood analyses, rheumatic tests, determination of -5T/C polymorphism in the GP1BA gene). An increased risk for IS was found in the young males versus the controls (healthy individuals; p = 0.03; OR 2.7; CI 1.14; 6.47). This association was not found in the women. Analysis of pathogenetic types ascertained that the lacunar IS men with CC and CT genotypes had a higher risk for stroke than the healthy individuals (p = 0.04, OR 3.5, CI 1.1; 10.9). In other subtypes of stroke, there was no association with this polymorphism. A group of patients with IS caused by thrombosis of the great arteries of the brain. In this group, the patients had CC and CT genotypes significantly more frequently than the controls (p = 0.003; OR 6.7; CI 2.0; 21.8), as well as C allele (p = 0.0008; OR 5.1; CI 1.97; 13.3). The -5T/C polymorphism in the GP1BA gene was associated with the development of IS in young males. The -5C allele and -5T/C and -5C/C genotypes are increased risk factors for lacunar and arterial thrombosis-induced IS in men.