Analysis of structure, causes, and risk factors of ischemic optic neuro-pathy

Шеремет, Н Л; Smirnova, T B; Ронзина, И А; Khanakova, N A; Мешков, А. Д.; Kozlovskaya, N L; Sheludchenko, V M

doi:10.17116/oftalma2017133650-58

Cited by 4 publications

(1 citation statement)

References 8 publications

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“…Бань продемонстрировала взаимосвязь стенозирования и псилатеральной ВСА с состоянием гемодинамики глаза и зрительных функций при острых артериальных нарушениях кровообращения сетчатки и зрительного нерва. По данным различных неврологических и офтальмологических исследований, за последние 5 лет вновь неоднократно подчёркивалась этиопатогенетическая связь между появлением и развитием хронической ишемии мозга и сосудистой оптической нейропатии [21,23,26,[76][77][78][79][80]. Результаты обследования пациентов с дисциркуляторной энцефалопатией, сочетанной с сосудистой оптической нейропатией, проведённого на базе Иркутского филиала НМИЦ МНТК «Микрохирургия глаза» и Больницы ИНЦ СО РАН, также выявили в качестве этиологических факторов наличие фоновых сосудистых заболеваний: гипертонической болезни, церебрального атеросклероза, ишемической болезни сердца в форме фибрилляции предсердий.…”

Section: концепция коморбидности дэ и ишемических оптических нейропатийunclassified

The concept of comorbidity of dyscirculatory encephalopathy and vascular optical neuropathy (literature review)

Юрьева

Zaika

2022

Acta biomedica scientifica

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The analysis of literature data on ischemic damage to the brain and the organ of vision was carried out in order to study etiological factors, pathogenetic processes, parallel flow and mutual influence of two nosological forms: dyscirculatory encephalopathy and vascular optic neuropathy. According to the World Health Organization, there is much more people suffering from cardiovascular diseases: atherosclerosis, hypertension, diabetes mellitus and coronary heart disease. These diseases result in ischemic damage to a number of vital organs, including the central nervous system and the visual analyzer. Chronic vascular pathology of both the brain and the eye is one of the leading causes of patients’ life quality decrease of and their disability. The “triggering” causes of brain and eye damage, according to researchers, are cerebral atherosclerosis, elevating/fluctuating blood pressure, coronary heart disease, and carbohydrate metabolism disorders. Disorders of the systemic blood supply caused by these etiological factors lead to a progressive lack of oxygen supply to organs and tissues, followed by the development of intracellular and cellular hypoxia, and an ischemic intracellular cascade of biochemical disorders leading to dysfunction and sometimes cell death.In addition to direct hypoxic-ischemic damage of the nervous and visual systems cells, endothelial dysfunction contributes to the progression of these diseases, leading to a pronounced change in the wall at the level of small vessels, a change in its reactivity and a violation of the coagulation properties of blood, and as a consequence, to a gradual accumulation of ischemic and secondary degenerative changes in brain and eye cells.Knowledge of etiological factors and patterns of development of brain and eye combined ischemic damage can allow clarifying the complex of diagnostic measures, developing preventive measures, as well as prescribe pathogenetically justified treatment of existing pathology.

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Section: концепция коморбидности дэ и ишемических оптических нейропатийunclassified