Analysis of the circRNAs expression profile in mouse lung with H7N9 influenza A virus infection

Liu, Zhiyuan; Guo, Yanna; Zhao, Lingcai; Liu, Qingzheng; Tian, Miao; Huang, Nan; Fan, Menglu; Yu, Min; Xia, Huizhi; Ping, Jihui

doi:10.1016/j.ygeno.2020.10.002

Cited by 9 publications

(10 citation statements)

References 34 publications

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“…Liu C. C. et al (2021) reported that 7,126 circRNAs were expressed in the lungs of mice infected with H7N9 or H7N9 PB2-mutant viruses, of which 186 were differentially expressed. This result shows that differentially expressed circRNAs have vital roles in immune regulation against viral infection (Liu Z. et al, 2021).…”

Section: Roles Of Circular Rnas In Virus Infectionmentioning

confidence: 86%

“…In terms of their unique ring structure, circRNAs have no terminated 5 end caps or 3 poly (A) tails, thus indicating the highly stable nuclease resistance (Starke et al, 2015). Accumulating evidences have indicated that circRNAs play vital roles in the regulation of IAV infection (Yu et al, 2019;Liu Z. et al, 2021;Shi et al, 2021; Table 1).…”

Section: Characteristics and Modes Of Action Of Non-coding Rnasmentioning

confidence: 99%

“…The authors concluded that circ-GATAD2A promoted the IAV replication by inhibiting autophagy (Yu et al, 2019; Table 1). Although numerous studies have characterized the expression profiling of circRNAs during virus infection and large numbers of circRNAs have been identified involving in the regulation of host-virus interactions (Liu Z. et al, 2021;Wang et al, 2021), the detailed molecular mechanisms are still limited and needs further investigation.…”

Section: Roles Of Circular Rnas In Virus Infectionmentioning

confidence: 99%

“…Generally, ncRNAs are involved in regulating biological, developmental, and physiological processes, even serving as molecular markers of some diseases (Pavet et al, 2011;Salzman, 2016;Adams et al, 2017;Zhu et al, 2018;Liu C. X. et al, 2019). Besides, the expression pattern of ncRNAs usually changes in response to various viral infections, indicating that ncRNAs play important roles in modulating viral infection by different mechanisms (Li et al, 2015;Ouyang et al, 2016;Liu Z. et al, 2021;Othumpangat et al, 2021).…”

Section: Introductionmentioning

confidence: 99%

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Functional Roles of Non-coding RNAs in the Interaction Between Host and Influenza A Virus

et al. 2021

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Non-coding RNAs (ncRNAs) are extensively expressed in various cells and tissues, and studies have shown that ncRNAs play significant roles in cell regulation. However, in the past few decades, the knowledge of ncRNAs has been increased dramatically due to their transcriptional ability and multiple regulatory functions. Typically, regulatory ncRNAs include long ncRNAs (lncRNAs), miRNAs, piRNAs, Y RNAs, vault RNAs, and circular RNAs (circRNAs), etc. Previous studies have revealed that various ncRNAs are involved in the host responses to virus infection and play critical roles in the regulation of host-virus interactions. In this review, we discuss the conceptual framework and biological regulations of ncRNAs to elucidate their functions in response to viral infection, especially influenza A virus (IAV) infection. In addition, we summarize the ncRNAs that are associated with innate immunity and involvement of interferons and their stimulated genes (ISGs) during IAV infection.

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Section: Roles Of Circular Rnas In Virus Infectionmentioning

confidence: 86%

Section: Characteristics and Modes Of Action Of Non-coding Rnasmentioning

confidence: 99%

Section: Roles Of Circular Rnas In Virus Infectionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Functional Roles of Non-coding RNAs in the Interaction Between Host and Influenza A Virus

et al. 2021

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“…It has been shown that a number of miRNAs are able to enhance the production of pro-inflammatory immune cells through upregulation of Th1 and Th17 signaling pathway ( 15 ). CircRNAs can serve as miRNA sponges to regulate the downstream mRNAs indirectly by carrying out the function of competing endogenous RNA (ceRNA) ( 16 – 18 ). A recent report reviewes the role of some “star circRNAs” in systemic lupus erythematosus (SLE) ( 19 , 20 ).…”

Section: Introductionmentioning

confidence: 99%

Analyses of circRNA and mRNA Profiles in Vogt–Koyanagi–Harada Disease

Shu

Zhang

et al. 2021

Front. Immunol.

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Recent studies revealed that circular RNAs (circRNAs) are important in numerous biological process and involved in autoimmune diseases. However, their role in Vogt–Koyanagi–Harada (VKH) disease, a classical autoimmune disease, is not yet known. This research aimed to study the expression profile of mRNAs, microRNAs (miRNAs) and circRNAs and investigate the influence of circRNAs on the pathogenesis of VKH disease. We identified circRNAs, miRNAs, and mRNAs expression profiles in CD4+ T cells between 4 VKH patients and 3 healthy controls using the whole-transcriptome sequencing (RNA-seq) technique. We discovered that a total of 5088 mRNAs, 451 circRNAs and 433 miRNAs were differently expressed. The GO and KEGG pathway enrichment analyses were performed for significantly differentially expressed circRNAs and mRNAs. GSEA was conducted for all mRNAs. The functional enrichment suggested that the inflammatory response, the adaptive immune response, NF-kappa B signaling pathway, Th17 cell differentiation, Th1 and Th2 cell differentiation and T cell receptor signaling pathway were associated with VKH disease. In addition, based on the immune-related genes we screened, the circRNA-miRNA-mRNA ceRNA network was analyzed and constructed. Ten differently expressed mRNAs (LAT, ZAP70, ITK, ICOS, RASGRP1, PAG1, PLCG1, PRKCQ, LCK, CARD11) and 5 differently expressed circRNAs (hsa_circ_0033144, hsa_circ_0000233, hsa_circ_0000396, hsa_circ_0001924, hsa_circ_0001320) were selected to be validated by Real-time qPCR (RT-qPCR). The results of RT-qPCR turned out to be consistent with RNA-seq data. Further analysis showed that hsa_circ_0001320 and hsa_circ_0001924 may serve as crucial candidate marker genes of VKH disease. These results reveal that circRNAs may have a crucial immunomodulatory function in the pathophysiological process of VKH disease.

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Regulatory role of ncRNAs in pulmonary epithelial and endothelial barriers: Molecular therapy clues of influenza-induced acute lung injury

Zhang

Yang

Liu

et al. 2022

Pharmacological Research

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Analysis of the circRNAs expression profile in mouse lung with H7N9 influenza A virus infection

Cited by 9 publications

References 34 publications

Functional Roles of Non-coding RNAs in the Interaction Between Host and Influenza A Virus

Functional Roles of Non-coding RNAs in the Interaction Between Host and Influenza A Virus

Analyses of circRNA and mRNA Profiles in Vogt–Koyanagi–Harada Disease

Regulatory role of ncRNAs in pulmonary epithelial and endothelial barriers: Molecular therapy clues of influenza-induced acute lung injury

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