Analysis of the cannabinoids

Harvey, David J.

doi:10.1007/978-1-349-06715-2_10

Cited by 6 publications

(5 citation statements)

References 207 publications

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“…The mouse showed the highest relative concentration of l l-hydroxy-Clibl with very little side-chain hydroxylation. This is similar to in vivo studies with other cannabinoids made in this laboratory where very little, if any, side-chain monohydroxy metabolites are produced by this species (5). A similar result bas recently been reported by Yamamoto et al (14).…”

Section: Discussionsupporting

confidence: 78%

“…The side-chain positions hydroxylated in these and other species were mainly the 1'-(benzylic) and 4'-(w-l) positions. Side-chain hydroxylation was prominent in the guinea pig, again correlating well with in vivo results where side-chain hydroxylation appears a feature of metabolism of a number of cannabinoids by this species (5,15). Yamamoto et al (14) have recently reported the in vitro metabolism of CBN in the guinea pig, but, interestingly, no 4'-hydroxylation was observed.…”

Section: Discussionsupporting

confidence: 56%

“…This is particularly significant in aged samples where its concentration can exceed that of delta-9-THC. Its metabolism had been studied in several laboratories (5) but, in common with other cannabinoids, different investigators have used a variety of species and conditions, thus making comparisons of metabolism by different species difficult This paper describes the in vitro metabolism of this drug in seven common laboratory species under the same conditions. …”

Section: Introductionmentioning

confidence: 99%

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In vitro metabolism of cannabinol in rat, mouse, rabbit, guinea pig, hamster, gerbil and cat

Brown

Harvey

1990

Eur. J. Drug Metab. Pharmacokinet.

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Metabolism of cannabinol (CBN) was studied in hepatic microsomal incubates from mouse, rat, rabbit, guinea pig, cat, hamster and gerbil. Metabolites were extracted with ethyl acetate, concentrated by chromatography on Sephadex LH-20 and identified by GC/MS as TMS derivatives. Six monohydroxy metabolites were identified. These had hydroxy groups at C-11 and at all positions of the pentyl side-chain. Metabolism varied considerably between the species. 11-Hydroxylation was the most prominent route in the majority of species, but in the hamster and cat the major metabolic pathway was 4'-hydroxylation. Metabolites hydroxylated in the pentyl chain were generally more abundant in guinea pig, hamster and cat.

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Section: Discussionsupporting

confidence: 78%

Section: Discussionsupporting

confidence: 56%

Section: Introductionmentioning

confidence: 99%

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In vitro metabolism of cannabinol in rat, mouse, rabbit, guinea pig, hamster, gerbil and cat

Brown

Harvey

1990

Eur. J. Drug Metab. Pharmacokinet.

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“…Its metabolism, which has been studied in rat microsomal preparations (4,5), mouse (6) and guinea pig (7) liver, microorganisms (8,9) and in both dog (10) and human urine (11), has been reviewed (12). This paper reports the identification of metabolites of CBO in the rat urine, bile and in the perfusion fluid from a rat perfusion preparation to determine the main excretory pathways of different metabolite types.…”

Section: Introductionmentioning

confidence: 99%

Metabolism of cannabidiol by the rat

Samara

Bialer

Harvey

1991

European Journal of Drug Metabolism and Pharmacokinetics

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Metabolites of CBD excreted into the bile and perfusion fluid were examined in a rat liver perfusion preparation. Metabolites were extracted with ethyl acetate and identified by GC/MS as TMS derivatives. Four mono- and five di-hydroxy metabolites were identified with major sites of metabolic attack being at C-7 and C-4". A hydroxy-ketone was detected but not fully identified. All biliary metabolites were conjugated with glucuronic acid. Urinary metabolites were studied in rats with samples taken at times to 25 h after drug administration. Unmetabolized CBD and 13 metabolites were identified by GC/MS. Major metabolites were acids with beta-oxidation being a prominent pathway. The 6- and 7-hydroxy derivatives of 4",5"-bis,nor-CBD-3"-oic acid were the most abundant compounds but substantial concentrations of the di-acids, CBD-5",7-dioic acid and 4",5"-bis,nor-CBD-3",7-dioic acid were present. Concentrations of the more highly oxidized metabolites increased with time.

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“…85 cannabinoids estimated to be synthesized by Cannabis sativa. [2][3][4] Receptors for cannabinoids were difficult to identify because of their highly lipophilic nature. During the 1980s, Pfizer embarked on a major effort to synthesize analogues based on the THC structure, one of which, CP55,940, a high affinity CB1 ligand, led to identification of two receptors for THC in the early 1990s.…”

mentioning

confidence: 99%

Cannabinoids Part I – Legal policies and physiological effects

Kerwin

2012

Drug Testing and Analysis

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Analysis of the cannabinoids

Cited by 6 publications

References 207 publications

In vitro metabolism of cannabinol in rat, mouse, rabbit, guinea pig, hamster, gerbil and cat

In vitro metabolism of cannabinol in rat, mouse, rabbit, guinea pig, hamster, gerbil and cat

Metabolism of cannabidiol by the rat

Cannabinoids Part I – Legal policies and physiological effects

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