Analysis of the Biocompatibility of Polymer Implant Materials

Карпунина, Т. И.; Годовалов, А. П.; Yakusheva, D. E.

doi:10.1007/s10527-020-09958-6

Cited by 3 publications

(2 citation statements)

References 18 publications

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“…Moreover, all these materials have been used in many different structural formats including thin films, foams, nano-/microfibers, hydrogels, etc. [Karpunina et al, 2020]. One of the most challenging parts of cell analysis in the biomaterials field is to obtain the cells from such complex structures without damaging them and also high-quality imaging of cells in such complex environments [Vrana et al, 2019].…”

Section: Biomaterials Risk Assessmentmentioning

confidence: 99%

Basis of Image Analysis for Evaluating Cell Biomaterial Interaction Using Brightfield Microscopy

Uka

Halili

Polisi

et al. 2021

Cells Tissues Organs

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Medical imaging is a growing field that has stemmed from the need to conduct noninvasive diagnosis, monitoring, and analysis of biological systems. With the developments and advances in the medical field and the new techniques that are used in the intervention of diseases, very soon the prevalence of implanted biomedical devices will be even more significant. The implanted materials in a biological system are used in diverse fields, which require lengthy evaluation and validation processes. However, currently the evaluation of the toxicity of biomaterials has not been fully automated yet. Moreover, image analysis is an integral part of biomaterial research, but it is not within the core capacities of a significant portion of biomaterial scientists, which results in the use of predominantly ready-made tools. The detailed image analysis can be conducted once all the relevant parameters including the inherent characteristics of image acquisition techniques are considered. Herein, we cover the currently used image analysis-based techniques for assessment of biomaterial/cell interaction with a specific focus on unstained brightfield microscopy acquired mostly in but not limited to microfluidic systems, which serve as multiparametric sensing platforms for noninvasive experimental measurements. We present the major imaging acquisition techniques that enable point-of-care testing when incorporated with microfluidic cells, discuss the constraints enforced by the geometry of the system and the material that is analyzed, and the challenges that rise in the image analysis when unstained cell imaging is employed. Emerging techniques such as utilization of machine learning and cell-specific pattern recognition algorithms and potential future directions are discussed. Automation and optimization of biomaterial assessment can facilitate the discovery of novel biomaterials together with making the validation of biomedical innovations cheaper and faster.

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Section: Biomaterials Risk Assessmentmentioning

confidence: 99%

Basis of Image Analysis for Evaluating Cell Biomaterial Interaction Using Brightfield Microscopy

Uka

Halili

Polisi

et al. 2021

Cells Tissues Organs

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“…на подопытных животных В экспериментальных исследованиях на крысах апробирован разработанный и запатентованный авторами способ имплантации полиуретановых образцов, снижающий побочные эффекты и позволяющий сфокусировать реактивность опытной модели преимущественно на свойствах имплантата [19].…”

Section: тестирование биосовместимостиunclassified

Implantable polyurethaneurea medical devices: synthesis, surface modification,bioсompatibility

Yakusheva¹,

Карпунина²,

Godovalov³

et al. 2021

Perm Sci. Cent. J.

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Bioinert coatings of Ti-Ta-N for medical implants obtained by electric explosion spraying and subsequent electron-ion-plasma modification

Романов¹,

Sosonin²,

Pronin³

et al. 2020

Mater. Res. Express

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The purpose of the research was to form a Ti-Ta-N- system bioinert coating on Ti6Al4V alloy surface as well as to study its structure and properties. The main contribution of the research is in the following. Electro-explosion spraying of tantalum coating on VT6 titanium alloy surface was pioneered in the research. After that the processing of the coating by low-energy high-current electron beam and subsequent nitriding was carried out in a single technological cycle. It has been established that a nanocrystalline coating based on tantalum, nitrogen and titanium was formed as a result of the technological operations. The phase composition of the coatings has been detected. The variations in crystal lattice parameters being formed in coating of phases and coherent scallering regions of these phases depending on power density of electron beam have been determined. Structural characteristics of the coatings at nano- and microlevel have been detected. Tests of coatings for nanohardness, the Young modulus, wear resistance and friction factor have been carried out. By all technical characteristics Ti-Ta-N-system coating exceeds titanium of VT6 grade. The cause of the increase in mechanical characteristics of the Ti-Ta-N-system coating is their nanostructural state and strengthening phases. Tests for proliferation activity of fibroplasts and antimicrobial activity have shown better results in comparison with VT6 titanium alloy as well. It is due to escape of vanadium ions from VT6 alloy into nutrient cell medium and their destructive effect on cell cultures. Variations in proliferation and antimicrobial activity develop due to amplification of cell proliferation. A complex of the obtained characteristics makes it possible to recommend Ti-Ta-N-system coating for its application as a bioinert coating on different implants in furure.

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Analysis of the Biocompatibility of Polymer Implant Materials

Cited by 3 publications

References 18 publications

Basis of Image Analysis for Evaluating Cell Biomaterial Interaction Using Brightfield Microscopy

Basis of Image Analysis for Evaluating Cell Biomaterial Interaction Using Brightfield Microscopy

Implantable polyurethaneurea medical devices: synthesis, surface modification,bioсompatibility

Bioinert coatings of Ti-Ta-N for medical implants obtained by electric explosion spraying and subsequent electron-ion-plasma modification

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