Analysis of the Association between Fat Mass Distribution and Bone Mass in Chinese Male Adolescents at Different Stages of Puberty

Deng, Kaili; Li, Hui; Yang, Wenyan; Jin-li, Hou; Xu, Yang; Xiao, Su-Mei

doi:10.3390/nu13072163

Cited by 7 publications

(9 citation statements)

References 65 publications

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“…As adipogenesis and osteogenesis involve dynamic processes related to multiple factors (30), it is challenging to predict the ultimate impact of adipose tissue on bone. The ndings of this study indicate that adipose tissue is detrimental to bone health, which is consistent with those of previous studies (31)(32)(33)(34). Maurin et al (35)found that adipose tissue could inhibit the proliferation of human osteoblasts in vitro utilizing the co-culture paradigm.…”

Section: Discussionsupporting

confidence: 92%

Association Between Segmental Body Composition and Bone Mineral Density in US Adults：Results from the NHANES (2011- 2018)

Lin

Wang

et al. 2023

Preprint

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Objective The association between segmental body composition and bone mineral density (BMD) is unclear. This study analyzed the representative adult sample from the US in order to evaluate the association between segmental body composition and BMD. Method Ten thousand and ninety-six people aged 20–59 from the National Health and Nutrition Examination Survey (NHANES) database participated in this cross-sectional study. Segmental body composition and total BMD were examined using weighted multivariate linear regression analysis. Additionally, a subgroup analysis was performed according to age and gender group. Result The fat proportion of each body region was negatively related to total BMD once confounding variables were taken into account, while the arm and leg showing the most significant negative correlation. Lean mass and BMD were positively correlated in each region. Similar results were observed in all hierarchical analyses. Conclusion In essence, we discovered that BMD in American individuals aged 20 to 59 was inversely linked with the percentage of fat mass in various body locations. The increase of lean mass in each region had a protective effect on bones. Segmental body composition analysis may be used to provide information for predicting the health status of bone.

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Section: Discussionsupporting

confidence: 92%

Association Between Segmental Body Composition and Bone Mineral Density in US Adults：Results from the NHANES (2011- 2018)

Lin

Wang

et al. 2023

Preprint

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“…Sex hormone concentration grows in mid-childhood [50]. Puberty, or sex hormone concentration, is a variable that has been suggested to have a significant impact on the relationship between body composition and bone mass [28,51]. In this study, the subgroup analysis showed that the pooled correlation coefficients of LM with total body BMD were higher in adolescents than in children.…”

Section: Discussionmentioning

confidence: 60%

“…However, some of the included studies only had data for total body bone measurements that included the head. Third, it is known that age and puberty stage play an important role in bone development [51]. Due to the lack of specific data, this study could not examine the effects of age or puberty status on the relationships between body composition and BMD.…”

Section: Discussionmentioning

confidence: 96%

“…Therefore, caution should be exercised when drawing conclusions from studies that report associations between FM and bone parameters without adjusting for LM or body weight. In addition, a previous study pointed out that the pattern of fat distribution may play a more important role than the total body fat in determining bone health [51]. Therefore, more emphasis should be given to the association between regional adiposity and bone health in the future.…”

Section: Discussionmentioning

confidence: 99%

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Association between Body Composition and Bone Mineral Density in Children and Adolescents: A Systematic Review and Meta-Analysis

Deng

Yang

Jin-li

et al. 2021

IJERPH

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Background: Bone mass acquisition during growth is a major determinant of the risk of developing osteoporosis later in life. Body composition is an anthropometric determinant of bone mineral density (BMD) and significantly influences its development during childhood and adolescence. Objective: This study aimed to systematically examine the association between body composition and bone mineral density in children and adolescents. Methods: Observational studies addressing this association were identified from PubMed (MEDLINE), Embase, Scopus and the Cochrane Library (up to January 2021). The study populations consisted of healthy children and adolescents. The DerSimonian and Laird method was used to compute pooled estimates of effect size and the respective 95% confidence intervals for upper limbs, femoral neck (FN), lumbar spine (LS) and total body, respectively. Subgroup analyses were further performed based on age, sex and ethnicity. Results: Thirty-one published studies were eligible for inclusion in this systematic review and meta-analysis, including three longitudinal studies. The combined population from all the studies amounted to 21,393 (11,205 males and 10,188 females). The pooled estimates of the correlation coefficients for lean mass (LM) and BMD ranged from 0.53 to 0.74 (p < 0.050), and the pooled regression coefficients ranged from 0.23 to 0.79 for FN, LS and total body (p < 0.050). For fat mass (FM), the pooled correlation coefficients ranged from 0.10 to 0.50 (p < 0.050) and the pooled regression coefficient was only significant for FN BMD with a weak strength (pooled β = 0.07, p < 0.050). The pooled regression coefficients for body fat percentage (BF%) were between −0.54 and −0.04 (p < 0.050). The subgroup analysis revealed a stronger association in Asians than in Caucasians for LM and in males compared to females for BF% (p < 0.050). Conclusions: This systematic review and meta-analysis supports a positive association between LM and BMD. BF% appears to have a deleterious effect on bone acquisition in children and adolescents.

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“…The anthropometric characteristics of participants including age, sex, and BMI were collected. BMI is defined as a participant’s weight in kilograms divided by the square of the height in meters in adults (kg/m 2 ) ( 25 ). Following the WHO BMI norms, the participants were divided into two groups of normal BMI (18.5<BMI<24.9 kg/m 2 ) and excess BMI (overweight/obesity, BMI≥ 25 kg/m 2 ).…”

Section: Methodsmentioning

confidence: 99%

The Optimal Axial Anatomical Site for a Single-Slice Area to Quantify the Total Volume of Visceral Adipose Tissue in Quantitative CT

Chen

et al. 2022

Front. Endocrinol.

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PurposeDetermine the association between cross-sectional visceral adipose tissue (VAT) area of different anatomic locations and total abdominopelvic VAT volume; identify the optimal measurement site in a single-slice to quantify the total VAT volume.MethodParticipants who underwent non-contrast abdominal scan by quantitative CT (QCT) were enrolled from May 2021 to October 2021. The VAT area (cm2) at different anatomic sites as upper-pole, lower-pole, and hilum of the kidney, intervertebral disc of L2/L3 and L5/S1, and umbilical level were measured on QCT PRO BMD workstation (Mindways QCT PRO workstation). The total VAT volume (cm3) from the upper pole of kidney to the L5/S1 intervertebral disc of the pelvis (abdominopelvic region) was obtained by using Siemens Healthineers Syngo via Frontier cardiac risk assessment. Regression models were used to identify the optimal single-slice in different gender for estimating VAT volume. Statistical significance was established at P < 0.05.ResultsTotal of 311 Chinese participants including 179 men [age, 55.1 ± 14.9 years; body mass index (BMI), 24.2 ± 3.2 kg/m2; total VAT volume, 2482.6 ± 1276.5 mL] and 132 women [age, 54.3 ± 14.9; BMI, 23.5 ± 2.9; total VAT volume, 1761.5 ± 876.4]. Pearson’s correlation analysis revealed a strong association between the VAT area and total abdominopelvic VAT volume at the hilum of the kidney in both men (r=0.938, P<0.001) and women (r=0.916, P<0.001). Adjust for covariates including age, BMI, and waist circumference make a relatively small effect on predicting the total VAT volume.ConclusionsMeasurement of cross-sectional areas at the hilum of the kidney in both genders showed a strongest relation to TVAT volume. Our results may provide an identifiable and valuable axial landmark for measuring visceral adipose tissue in clinical practice.

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Analysis of the Association between Fat Mass Distribution and Bone Mass in Chinese Male Adolescents at Different Stages of Puberty

Cited by 7 publications

References 65 publications

Association Between Segmental Body Composition and Bone Mineral Density in US Adults：Results from the NHANES (2011- 2018)

Association Between Segmental Body Composition and Bone Mineral Density in US Adults：Results from the NHANES (2011- 2018)

Association between Body Composition and Bone Mineral Density in Children and Adolescents: A Systematic Review and Meta-Analysis

The Optimal Axial Anatomical Site for a Single-Slice Area to Quantify the Total Volume of Visceral Adipose Tissue in Quantitative CT

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