Association Between Segmental Body Composition and Bone Mineral Density in US Adults：Results from the NHANES (2011- 2018)

Lin, Yanze; Wu, Ruiji; Wang, Xun; Zhou, Jinlei; Feng, Fabo

doi:10.21203/rs.3.rs-2558735/v1

Cited by 1 publication

(1 citation statement)

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“…An estimated 1.5 million fractures are caused by OP each year in the United States (3,4). The economic burden of treating osteoporotic fractures is expected to reach nearly $50 billion by 2040, putting tremendous strain on American society (5,6). Currently, the gold standard for diagnosing OP is to assess a patient's bone mineral density (BMD) (7,8).…”

Section: Introductionmentioning

confidence: 99%

Association between the atherogenic index of plasma and bone mineral density among adult women: NHANES (2011–2018)

He,

Chen,

Liang

et al. 2024

Front. Endocrinol.

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BackgroundStudies on the relationship between the atherogenic index of plasma (AIP) and bone mineral density (BMD) among adult women in the United States are limited. The purpose of this study was to explore this association using a sizable, nationally representative sample.MethodsData from the 2011 to 2018 National Health and Nutrition Examination Survey (NHANES) were used in this observational study. The AIP was computed as log10 (triglycerides/high-density lipoprotein cholesterol). Total BMD was measured via dual-energy X-ray densitometry. We constructed multiple linear regression models to evaluate the correlation between the AIP and BMD. The non-linear relationship was characterized by smooth curve fitting and generalized additive models. We also conducted subgroup and interaction analyses.ResultsIn this study, we included 2,362 adult women with a mean age of 38.13 ± 12.42 years. The results of multiple linear regression analysis, the AIP and total BMD showed a negative association (β = −0.021, 95%CI: −0.037, −0.006). The curve fitting analysis and threshold effect analysis showed a non-linear relationship between the two variables, and the inflection point of the AIP was found to be -0.61. The total BMD decreased significantly when the AIP reached this value (β = −0.03, 95%CI: −0.04, −0.01). The results of the subgroup analysis showed that AIP and total BMD had a strong negative relationship in participants who were below 45 years old (β = -0.023; 95% CI: -0.041, -0.004), overweight (BMI ≥ 25 kg/m2) (β = -0.022; 95% CI: -0.041, -0.002), had a higher education level (β = -0.025; 95% CI: -0.044, -0.006), and had no partners (β = -0.014; 95% CI: -0.06, -0.009).ConclusionsWe found a negative correlation between the AIP and total BMD. Clinicians should pay attention to patients with high AIP, which might indicate a low BMD and has reference significance in preventing osteoporosis.

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