Analysis of the APOB Gene and Apolipoprotein B Serum Levels in a Mexican Population with Acute Coronary Syndrome: Association with the Single Nucleotide Variants rs1469513, rs673548, rs676210, and rs1042034

Abstract

Apolipoprotein B (APOB) is associated with the development of atherosclerosis and consequently in the acute coronary syndrome (ACS) physiopathology. Single number variants (SNVs) in apolipoprotein B gene (APOB) influence over the susceptibility for this syndrome. The aim of this study was to determine the impact of the rs1469513, rs673548, rs676210, and rs1042034 SNVs and serum levels of APOB in the risk of ACS in a population from western Mexico. We included 300 patients in the group of cases (ACSG) and 300 individuals in the control group (CG). APOB levels were evaluated by immunonephelometry, and SNVs were genotyped with TaqMan probes. We found significant allelic and genotypic differences between groups for rs673548 and rs676210 (OR = 1.33, p = 0.030 , OR = 2.69, p < 0.001 ) and rs1042034 (OR = 0.50, p = 0.037 ) SNVs. We found a risk haplotype TAGT (OR: 2.14, IC 1.50–3.04, p < 0.001 ). Our findings support a significant risk association between rs673548 and rs676210 variants for ACS; meanwhile, rs1042034 could be considered protective factor in a western Mexican population. Also, in this population, haplotype TAGT may confer 2.14 times a higher risk. APOB serum levels were compared by genotype variants in both groups without any significant statistical difference.

Haplotype analysis and linkage disequilibrium of ApoB gene polymorphisms and its relationship with hyperlipidemia in patients with acne vulgaris

“…Increased levels of serum ApoB and TG, TC, and LDL‐C in patients with AV can be explained by the important role of serum ApoB as a primary protein component in the biosynthesis of LDL‐C. Also, serum ApoB binds with TG, lipoprotein A and intermediate low‐density lipoprotein in plasma 15 . Interestingly, we indicated clearly in this study the linear correlation between serum ApoB and TG, TC and LDL‐C.…”

“…Our study revealed significant variations between the acne group and healthy controls in serum ApoB, TG, TC and LDL-C, and this result aligns with those of several studies 3,4,7,12,14. Increased levels of serum ApoB and TG, TC, and LDL-C in patients with AV can be explained by the important role of serum ApoB as a primary protein component in the biosynthesis of LDL-C. Also, serum ApoB binds with TG, lipoprotein A and intermediate low-density lipoprotein in plasma 15. Interestingly, we indicated clearly in this study the linear correlation between serum ApoB and TG, TC and LDL-C.Since it is well known that genetic factors play a vital role in changing lipid profiles in patients with AV, we selected a group of SNPs in different areas of the ApoB gene in order to study the correlations with serum levels of lipid profiles and ApoB.…”

Population-enriched innate immune variants may identify candidate gene targets at the intersection of cancer and cardio-metabolic disease

“…Another population-enriched missense APOB variant, 2-21008652-G-A (rs676210) (present in 73% of East Asians vs. 15% of Africans/African Americans (gnomAD)) correlated with the occurrence of initial non-cardioembolic ischemic stroke in a small European cohort ( 239 ). A third population-enriched missense APOB variant, 2-21028042-G-A (rs679899) (present in 85% of East Asians vs. 17% of Africans/African Americans (gnomAD)) and was protective against acute coronary syndrome in a Mexican population ( 238 ). This was associated with both hypertension and chronic kidney disease in a cohort of 3696 Japanese individuals ( 240 ).…”