Analysis of the anatomy of the Papez circuit and adjoining limbic system by fiber dissection techniques

Shah, Abhidha; Jhawar, Sanjay; Goel, Atul

doi:10.1016/j.jocn.2011.04.039

Cited by 183 publications

(136 citation statements)

References 11 publications

Supporting

Mentioning

130

Contrasting

Unclassified

Order By: Relevance

“…2). Finally, we found damage in the long inter-regional connections formed by the inferior and superior longitudinal fasciculi, and more localized damage to the cingulum of the hippocampus, which is a critical pathway within the Papez Circuit (Shah et al, 2012).…”

Section: Resultsmentioning

confidence: 77%

White Matter Damage Disorganizes Brain Functional Networks in Amnestic Mild Cognitive Impairment

et al. 2014

View full text Add to dashboard Cite

Although progressive functional brain network disruption has been one of the hallmarks of Alzheimer's Disease, little is known about the origin of this functional impairment that underlies cognitive symptoms. We investigated how the loss of white matter (WM) integrity disrupts the organization of the functional networks at different frequency bands. The analyses were performed in a sample of healthy elders and mild cognitive impairment (MCI) subjects. Spontaneous brain magnetic activity (measured with magnetoencephalography) was characterized with phase synchronization analysis, and graph theory was applied to the functional networks. We identified WM areas (using diffusion weighted magnetic resonance imaging) that showed a statistical dependence between the fractional anisotropy and the graph metrics. These regions are part of an episodic memory network and were also related to cognitive functions. Our data support the hypothesis that disruption of the anatomical networks influences the organization at the functional level resulting in the prodromal dementia syndrome of MCI.

show abstract

Section: Resultsmentioning

confidence: 77%

White Matter Damage Disorganizes Brain Functional Networks in Amnestic Mild Cognitive Impairment

et al. 2014

View full text Add to dashboard Cite

show abstract

“…For example, although the hippocampal formation is one of the few areas in the adult brain where neurogenesis continues to occur, it is surprising that the images that give a comprehensive view of this important limbic region and its main efferent fiber pathway are sparse (Shah et al, 2012). In the dissected brains, it is possible to observe the location of the hippocampus proper in the inferior wall of the inferior horn of the lateral ventricle, the dentate gyrus and the fimbria.…”

Section: Discussionmentioning

confidence: 99%

“…Finally, it is possible to visualize the dissected mamillothalamic tract directed to the anterior part of the dissected thalamus. As the cingulate gyrus is also visible, the main components of the classic Papez circuit can be observed and named (Shah et al, 2012). Further examples are the cerebellar nuclei and their relation with the cerebellar peduncles that are difficult to visualize in three dimensions (Perrini et al, 2013).…”

Section: Discussionmentioning

confidence: 99%

Neuroanatomy: The added value of the Klingler method

Silva

Andrade

2016

Annals of Anatomy - Anatomischer Anzeiger

View full text Add to dashboard Cite

“…The fronto-limbic circuit, which manages executive function, learning and memory, emotions, and fear behavior, has been of clinical and academic concern for more than 100 years (Newman and Harris, 2009;Papez, 1995;Shah et al, 2012;Triarhou, 2008). These are functions that most distinguish humans, and to a large extent non-human primates, including Rhesus macaque, from lower animals.…”

Section: Discussionmentioning

confidence: 99%

A novel analytical brain block tool to enable functional annotation of discriminatory transcript biomarkers among discrete regions of the fronto-limbic circuit in primate brain

et al. 2015

View full text Add to dashboard Cite

Fronto-limbic circuits in the primate brain are responsible for executive function, learning and memory, and emotions, including fear. Consequently, changes in gene expression in cortical and subcortical brain regions housing these circuits are associated with many important psychiatric and neurological disorders. While high quality gene expression profiles can be identified in brains from model organisms, primate brains have unique features such as Brodmann Area 25, which is absent in rodents, yet profoundly important in primates, including humans. The potential insights to be gained from studying the human brain are complicated by the fact that the post-mortem interval (PMI) is variable, and most repositories keep solid tissue in the deep frozen state. Consequently, sampling the important medial and internal regions of these brains is difficult. Here we describe a novel method for obtaining discrete regions from the fronto-limbic circuits of a 4 year old and a 5 year old, male, intact, frozen non-human primate (NHP) brain, for which the PMI is exactly known. The method also preserves high quality RNA, from which we use transcriptional profiling and a new algorithm to identify region-exclusive RNA signatures for Area 25 (NFκB and dopamine receptor signaling), the anterior cingulate cortex (LXR/RXR signaling), the amygdala (semaphorin signaling), and the hippocampus (Ca(++) and retinoic acid signaling). The RNA signatures not only reflect function of the different regions, but also include highly expressed RNAs for which function is either poorly understood, or which generate proteins presently lacking annotated functions. We suggest that this new approach will provide a useful strategy for identifying changes in fronto-limbic system biology underlying normal development, aging and disease in the human brain.

show abstract

Analysis of the anatomy of the Papez circuit and adjoining limbic system by fiber dissection techniques

Cited by 183 publications

References 11 publications

White Matter Damage Disorganizes Brain Functional Networks in Amnestic Mild Cognitive Impairment

White Matter Damage Disorganizes Brain Functional Networks in Amnestic Mild Cognitive Impairment

Neuroanatomy: The added value of the Klingler method

A novel analytical brain block tool to enable functional annotation of discriminatory transcript biomarkers among discrete regions of the fronto-limbic circuit in primate brain

Contact Info

Product

Resources

About