“…However, the use of beneficial microbes is hindered by a lack of risk assessment and ethical frameworks, necessitating a careful balance between the risk of inaction and the need for rapid action [ 40 ]. Selecting and applying probiotics for wildlife involves science-informed exclusion of potential pathogens and consideration of ethical and environmental safety management [ 40 , 45 ]. Global debates with stakeholders, independent scientific entities, and community consultations aligned with international regulations should inform decisions [ 40 , 45 ].…”
Section: Reviewmentioning
confidence: 99%
“…Selecting and applying probiotics for wildlife involves science-informed exclusion of potential pathogens and consideration of ethical and environmental safety management [ 40 , 45 ]. Global debates with stakeholders, independent scientific entities, and community consultations aligned with international regulations should inform decisions [ 40 , 45 ].…”
Rheumatic diseases are a group of disorders that affect the joints, muscles, and bones. These diseases, such as rheumatoid arthritis, lupus, and psoriatic arthritis, can cause pain, stiffness, and swelling, leading to reduced mobility and disability. Recent studies have identified the microbiome, the diverse community of microorganisms that live in and on the human body, as a potential factor in the development and progression of rheumatic diseases. Harnessing the microbiome offers a promising new avenue for developing therapeutic strategies for these debilitating conditions. There is growing interest in the role of oral and gut microbiomes in the management of rheumatoid arthritis and other autoimmune disease. Microbial metabolites have immunomodulatory properties that could be exploited for rheumatic disorders. A wide range of microorganisms are present in the oral cavity and are found to be vulnerable to the effects of the environment. The physiology and ecology of the microbiota become intimately connected with those of the host, and they critically influence the promotion of health or progression toward disease. This article aims to provide a comprehensive overview of the current state of knowledge on oral and gut microbiome and its potential future role in the management of rheumatic diseases. This article will also discuss newer treatment strategies such as bioinformatic analyses and fecal transplantation.
“…However, the use of beneficial microbes is hindered by a lack of risk assessment and ethical frameworks, necessitating a careful balance between the risk of inaction and the need for rapid action [ 40 ]. Selecting and applying probiotics for wildlife involves science-informed exclusion of potential pathogens and consideration of ethical and environmental safety management [ 40 , 45 ]. Global debates with stakeholders, independent scientific entities, and community consultations aligned with international regulations should inform decisions [ 40 , 45 ].…”
Section: Reviewmentioning
confidence: 99%
“…Selecting and applying probiotics for wildlife involves science-informed exclusion of potential pathogens and consideration of ethical and environmental safety management [ 40 , 45 ]. Global debates with stakeholders, independent scientific entities, and community consultations aligned with international regulations should inform decisions [ 40 , 45 ].…”
Rheumatic diseases are a group of disorders that affect the joints, muscles, and bones. These diseases, such as rheumatoid arthritis, lupus, and psoriatic arthritis, can cause pain, stiffness, and swelling, leading to reduced mobility and disability. Recent studies have identified the microbiome, the diverse community of microorganisms that live in and on the human body, as a potential factor in the development and progression of rheumatic diseases. Harnessing the microbiome offers a promising new avenue for developing therapeutic strategies for these debilitating conditions. There is growing interest in the role of oral and gut microbiomes in the management of rheumatoid arthritis and other autoimmune disease. Microbial metabolites have immunomodulatory properties that could be exploited for rheumatic disorders. A wide range of microorganisms are present in the oral cavity and are found to be vulnerable to the effects of the environment. The physiology and ecology of the microbiota become intimately connected with those of the host, and they critically influence the promotion of health or progression toward disease. This article aims to provide a comprehensive overview of the current state of knowledge on oral and gut microbiome and its potential future role in the management of rheumatic diseases. This article will also discuss newer treatment strategies such as bioinformatic analyses and fecal transplantation.
“…parasalivarius strains, ZAP-70-mutant SKG mice developed chronic arthritis [ 159 ]. A case‒control study reported that Treponema was greatly enriched in the PD and RA groups compared with the healthy controls by analyzing subgingival plaques [ 160 ]. In addition, early-stage RA patients and at-risk individuals had higher levels of Prevotella and Veillonella in saliva samples [ 161 ].…”
The human body is colonized by abundant and diverse microorganisms, collectively known as the microbiome. The oral cavity has more than 700 species of bacteria and consists of unique microbiome niches on mucosal surfaces, on tooth hard tissue, and in saliva. The homeostatic balance between the oral microbiota and the immune system plays an indispensable role in maintaining the well-being and health status of the human host. Growing evidence has demonstrated that oral microbiota dysbiosis is actively involved in regulating the initiation and progression of an array of autoimmune diseases.Oral microbiota dysbiosis is driven by multiple factors, such as host genetic factors, dietary habits, stress, smoking, administration of antibiotics, tissue injury and infection. The dysregulation in the oral microbiome plays a crucial role in triggering and promoting autoimmune diseases via several mechanisms, including microbial translocation, molecular mimicry, autoantigen overproduction, and amplification of autoimmune responses by cytokines. Good oral hygiene behaviors, low carbohydrate diets, healthy lifestyles, usage of prebiotics, probiotics or synbiotics, oral microbiota transplantation and nanomedicine-based therapeutics are promising avenues for maintaining a balanced oral microbiome and treating oral microbiota-mediated autoimmune diseases. Thus, a comprehensive understanding of the relationship between oral microbiota dysbiosis and autoimmune diseases is critical for providing novel insights into the development of oral microbiota-based therapeutic approaches for combating these refractory diseases.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.