Analysis of steroids in environmental water samples using solid-phase extraction and ion-trap gas chromatography–mass spectrometry and gas chromatography–tandem mass spectrometry

Kelly, Carole

doi:10.1016/s0021-9673(99)01261-3

Cited by 105 publications

(49 citation statements)

References 3 publications

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“…Solid phase extraction (SPE) and pressurized liquid extraction (PLE) approaches are the two techniques which have been increasingly used in the extraction of organic compounds in aqueous and solid samples [31][32][33]. Various SPE cartridges such as C18 and HLB have been applied in the extraction of organic compounds in water samples [2,8,23].…”

Section: Introductionmentioning

confidence: 99%

Simultaneous determination of benzotriazoles and ultraviolet filters in ground water, effluent and biosolid samples using gas chromatography–tandem mass spectrometry

Liu

Ying

Shareef

et al. 2011

Journal of Chromatography A

138

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Section: Introductionmentioning

confidence: 99%

Simultaneous determination of benzotriazoles and ultraviolet filters in ground water, effluent and biosolid samples using gas chromatography–tandem mass spectrometry

Liu

Ying

Shareef

et al. 2011

Journal of Chromatography A

138

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“…Although both LC-MS [15][16][17][18][19][20] and GC-MS [15,16,[21][22][23] have been used for the rapid and sensitive identification of estrogens and their metabolites, GC-MS usually requires derivatization which adds to the complexity of sample preparation, increases the time required per analysis, and might introduce artifacts. To eliminate the need for sample derivatization, we developed a method based on LC-MS-MS. From among the solution-phase ionization methods that have been reported for the mass spectrometric analysis of estrogens, such as fast atom bombardment (FAB) [24,25], atmospheric pressure chemical ionization (APCI) [15,19], and electrospray [15,16,20,25,26], we selected electro-spray ionization.…”

mentioning

confidence: 99%

Ultrafiltration tandem mass spectrometry of estrogens for characterization of structure and affinity for human estrogen receptors

Sun

Liu

et al. 2005

J. Am. Soc. Mass Spectrom.

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Although hormone replacement therapy (HRT) is used by post-menopausal women for the relief of menopausal symptoms and the potential reduction of osteoporosis, HRT also increases their risk of Alzheimer's disease, stroke, breast cancer, and endometrial cancer. Since the majority of these effects are associated primarily with estrogen binding to only one of the estrogen receptors (ER), new assays are needed that can more efficiently evaluate ER-binding and identify ligands selective for ER-␣ and ER-␤. High performance liquid chromatographytandem mass spectrometry (LC-MS-MS) was combined with ultrafiltration as a new method to investigate the relative binding of compounds to the ERs and to evaluate the structures of these estrogens. Mixtures of estradiol and six equine estrogens, including equilin, equilenin, 8,9-dehydroestrone, and their 17␤-hydroxyl derivatives, were assayed simultaneously to determine their relative binding to human ER-␣ and ER-␤. Estrogens containing a 17␤-OH group were found to have higher relative affinities for the estrogen receptors than their ketone analogs. In addition, 17␤-EN showed selectivity for binding to ER-␤ over ER-␣. The results were compared to the IC 50 values obtained by using a conventional radiolabled estradiol competitive binding assay. Finally, the utility of negative ion electrospray tandem mass spectrometry for the unambiguous identification of these estrogen isomers was investigated. Several characteristic recyclization pathways during tandem mass spectrometry were identified, which might be useful for distinguishing related estrogens. (J Am Soc Mass Spectrom 2005, 16, 271-279)

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“…This process involves the off-line purification of substances using solid phase extraction (SPE) and specific compounds for derivatization, prior to GC-MS analysis (i.e. Kelly, 2000;Kuch and Ballschmiter, 2000;Jeannot et al, 2002). To analyze plant and water samples for estrogenic compounds, off-line sample preparation was necessary.…”

Section: Estrogen and The Estrogen Derivative Gc-ms Analysesmentioning

confidence: 99%

Invasive species may offer advanced phytoremediation of endocrine<br>disrupting chemicals in aquatic ecosystems

Trueman

Erber

2013

Emir. J. Food Agric

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One of the major areas of advancement in environmental science is bioremediation. Researchers have been using bacteria, fungi, algae and now macrophytes to remove pollutants from aquatic and terrestrial ecosystems. Here we share the results of a study on the macrophyte uptake of xenoestrogens from an urban river. We found that the invasive curly leaf pond weed (Potamogeton illinoensis) accumulated an average of 66% higher levels of estrogenic compounds and 94% more Bisphenol-A than the native Illinois pondweed (Potamogeton crispus) in an urban river, in the watershed for the greater Chicago, IL area. The invasive species accumulated 76% more estrone, 55% more 17 β-estradiol and 31% more 17 α-ethynylestradiol than the native species. The Nonnative plants were also 72% larger than the native Illinois Pondweed. Managers may consider using invasive species to remove pollutants from ecosystems and restore ecosystem biogeochemistry.

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Analysis of steroids in environmental water samples using solid-phase extraction and ion-trap gas chromatography–mass spectrometry and gas chromatography–tandem mass spectrometry

Cited by 105 publications

References 3 publications

Simultaneous determination of benzotriazoles and ultraviolet filters in ground water, effluent and biosolid samples using gas chromatography–tandem mass spectrometry

Simultaneous determination of benzotriazoles and ultraviolet filters in ground water, effluent and biosolid samples using gas chromatography–tandem mass spectrometry

Ultrafiltration tandem mass spectrometry of estrogens for characterization of structure and affinity for human estrogen receptors

Invasive species may offer advanced phytoremediation of endocrine<br>disrupting chemicals in aquatic ecosystems

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