Analysis of Some Organosilicon Compounds in Biological Materal

Vessman, Jörgen; Hammar, Carl-Gustaf; Lindeke, Björn; Strömberg, Signhild; LeVier, Robert R.; Robinson, Ron; Spielvogel, David E.; Hanneman, Larry F.

doi:10.1007/978-1-4613-4018-8_25

Cited by 4 publications

(3 citation statements)

References 16 publications

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“…Si–O cleavage can be expected to occur in living organisms also after an organooligosiloxane is incorporated. This had in fact been observed early, as cis -2,6-diphenylhexamethylcyclotetrasiloxane was converted to Me 2 Si(OH) 2 , PhMeSi(OH) 2 , (HO)PhMeSiOSiMe 2 (OH) in rat, monkey, and man . Small amounts of three compounds thought to be MeSi(OH) 3 , PhSi(OH) 3 , and phenol were also formed; see Scheme .…”

Section: Degradation Of Organosiloxanesmentioning

confidence: 99%

“…Several further Si-containing compounds aquired the status of drug candidates up to human clinical trials but were not further developed for various reasons. , Unfortunately, we found information on the metabolism of only one of these compounds. Three minor products obtained after administering 2,6- cis -diphenylhexamethylcyclotetrasiloxane to rat, monkey, and humans were tentatively identified as MeSi(OH) 3 , PhSi(OH) 3 , and phenol, all being products of Si–C cleavage; see section , Scheme …”

Section: Degradation Of Organosiloxanesmentioning

confidence: 99%

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Environmental Chemistry of Organosiloxanes

2014

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Section: Degradation Of Organosiloxanesmentioning

confidence: 99%

Section: Degradation Of Organosiloxanesmentioning

confidence: 99%

Environmental Chemistry of Organosiloxanes

2014

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“…Organ specimens analyzed at post mortern examinations indicate that Cisobitan accumulates in fat and prostate tissues. The major metabolites in man have been identified as silanediols: dimethylsilanediol, methylphenylsilanediol and trimethylphenyldisiloxanediol (Vessman, Hammar, Lindeke, Stromberg, Levier, Robinson, Spielvogel & Hanneman, 1978). The major metabolites in man have been identified as silanediols: dimethylsilanediol, methylphenylsilanediol and trimethylphenyldisiloxanediol (Vessman, Hammar, Lindeke, Stromberg, Levier, Robinson, Spielvogel & Hanneman, 1978).…”

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Cisobitan® in Treatment of Prostatic Cancer

Alfthan

Andersson

et al. 1983

Scandinavian Journal of Urology and Nephrology

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Cisobitan, an organosilicon compound with estrogenic and antigonadotropic properties has been evaluated clinically in comparison with an estrogen preparation. In a multicenter study a total of 140 patients with well and moderately well differentiated prostatic cancer were randomly allocated to treatment with Cisobitan or Estradurin/Etivex, 70 to each group. Of 34 patients with poorly differentiated prostatic cancer 18 were given Cisobitan--and 16 were given Estracyt-treatment. Among the patients with well and moderately well differentiated prostatic cancer there were, disregarding mortality, no major differences in subjective, objective or laboratory response to the two kinds of treatment. The pattern of side effects was similar, but oedema requiring diuretics occurred more often in the estrogen treated group. There was a significant difference in mortality at 12 months between the groups, two in the Cisobitan group and ten in the estrogen treated group. Cancer was the cause of death in two patients in the estrogen treated group. All other patients succumbed in cardiovascular diseases. At 24 months the difference in mortality rate was less pronounced: Another ten patients had died in the Cisobitan treated group and seven among the estrogen treated patients. Cancer was responsible for the deaths in seven of the Cisobitan patients compared to four of the estrogen treated patients. Within three years one more patient in both groups had died. Of the 34 patients with poorly differentiated cancer, twelve were alive at the 24 months' follow up, six in the Cisobitan group and six in the Estracyt group.

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Syntheses and properties of bioactive organo-silicon compounds

Tacke

Wannagat

Topics in Current Chemistry

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Analysis of Some Organosilicon Compounds in Biological Materal

Cited by 4 publications

References 16 publications

Environmental Chemistry of Organosiloxanes

Environmental Chemistry of Organosiloxanes

Cisobitan® in Treatment of Prostatic Cancer

Syntheses and properties of bioactive organo-silicon compounds

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