Analysis of sleep, daytime sleepiness, and autonomic function in multiple system atrophy and Parkinson disease: a prospective study

Eckhardt, Christine; Fanciulli, Alessandra; Högl, Birgit; Heidbreder, Anna; Eschlböck, Sabine; Raccagni, Cecilia; Krismer, Florian; Leys, Fabian; Kiechl, Stefan; Ransmayr, Gerhard; Frauscher, Birgit; Seppi, Klaus; Wenning, Gregor K.; Stefani, Ambra

doi:10.5664/jcsm.10268

Cited by 4 publications

(3 citation statements)

References 51 publications

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“…Moreover, the heart rate response to leg movements was significantly lower in patients with Parkinson’s disease and iRBD compared to controls ( Sorensen et al, 2012 ). Other autonomic functions that were reported to be impaired in RBD included sudomotor abnormalities ( Zitser et al, 2020 ), impaired temperature sensation with higher thermal detection thresholds ( Strobel et al, 2018 ), lower supine norepinephrine plasma levels and adversely affected cold and vibration detection threshold levels in quantitative sensory testing ( Koch et al, 2022 ), and orthostatic hypotension and constipation ( Eckhardt et al, 2023 ).…”

Section: Rem Sleep Behavior Disordermentioning

confidence: 99%

Clinical neurophysiology of REM parasomnias: Diagnostic aspects and insights into pathophysiology

Bergmann,

Högl,

Stefani

2024

Clinical Neurophysiology Practice

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Section: Rem Sleep Behavior Disordermentioning

confidence: 99%

Clinical neurophysiology of REM parasomnias: Diagnostic aspects and insights into pathophysiology

Bergmann,

Högl,

Stefani

2024

Clinical Neurophysiology Practice

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“…In patients with dementia with Lewy bodies, sleep disorders such as REM sleep behavior disorder, insomnia, snoring, sleep apnea, hypersomnia, restless legs syndrome, and nocturnal visual hallucinations have been described [10]. Patients with multiple system atrophy report REM sleep behavior disorder, sleep fragmentation, sleep-related breathing disorders, and excessive daytime sleepiness [11,12]. In progressive supranuclear palsy, REM sleep behavior disorder can be present in 10-20% of patients, and insomnia is frequent [13].…”

Section: Sleep and Circadian Rhythms In Neurodegenerative Diseasesmentioning

confidence: 99%

The Bidirectional Relationship between Sleep and Neurodegeneration: Actionability to Improve Brain Health

Ibrahim,

Högl,

Stefani

2024

CTN

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Recently, it has become increasingly clear that there is a bidirectional relationship between sleep/circadian rhythms and neurodegeneration. Knowledge about this topic further improved after the description of the glymphatic system, which is mainly active during sleep. Changes in sleep and circadian rhythms are present not only in overt neurodegenerative diseases but also in their early, prodromal, and preclinical phases, supporting that they precede (and contribute to) the development of neurodegeneration. This narrative review provides a brief overview of sleep and circadian rhythm disruption in neurodegeneration, highlights the bidirectional relationship between sleep changes and neurodegeneration, and addresses future perspectives, in particular, whether sleep changes are able to predict neurodegeneration and the potential sleep actionability to prevent or modulate the development of neurodegenerative diseases.

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“…[ 15 , 21 , 22 , 23 ]. Additionally, some studies have described the relationship between excessive daytime sleepiness (EDS) and autonomic parameter activity in different cardiorespiratory (obstructive sleep apnea, hypertension) [ 24 , 25 ] and neurological (spinal cord injury, Parkinson’s disease) [ 26 , 27 ] patient cohorts. Nevertheless, the physiological mechanism behind this association remains unclear.…”

Section: Introductionmentioning

confidence: 99%

Association between Daytime Sleepiness, Fatigue and Autonomic Responses during Head-Up Tilt Test in Multiple Sclerosis Patients

Zawadka-Kunikowska,

Rzepiński,

Cieślicka

et al. 2023

Brain Sciences

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We aimed to assess dynamic changes in hemodynamic and autonomic function in response to the head-up tilt test (HUTT) in patients with multiple sclerosis (MS) compared to healthy controls (HCs) and evaluate its relationship with the patients’ reported daytime sleepiness and fatigue symptoms. A total of 58 MS patients and 30 HCs were included in the analysis. Fatigue and sleepiness were evaluated using the Chalder Fatigue Scale (CFQ) and the Epworth Sleepiness Scale (ESS), respectively. Hemodynamic response, baroreflex sensitivity, heart rate variability, and systolic and diastolic blood pressure (BP) variability (SBPV, DBPV) parameters were calculated at rest, and in response to the HUTT. The MS patients displayed attenuated BP responses coupled with a more pronounced decrease in cardiac index as well as a reduced increase in the low frequency (LFnu) of DBPV (p = 0.021) and the sympathovagal ratio (p = 0.031) in the latter-phase orthostatic challenge compared to HCs. In MS patients, the ESS score showed no correlation with CFQ or clinical disease outcomes, but exhibited a moderate correlation with LFnu of BPVrest. Fatigue and disease variants predicted blood pressure response to HUTT. These findings underscore the importance of subjective daytime sleepiness and fatigue symptoms and their role in blood pressure regulation in MS patients.

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Analysis of sleep, daytime sleepiness, and autonomic function in multiple system atrophy and Parkinson disease: a prospective study

Cited by 4 publications

References 51 publications

Clinical neurophysiology of REM parasomnias: Diagnostic aspects and insights into pathophysiology

Clinical neurophysiology of REM parasomnias: Diagnostic aspects and insights into pathophysiology

The Bidirectional Relationship between Sleep and Neurodegeneration: Actionability to Improve Brain Health

Association between Daytime Sleepiness, Fatigue and Autonomic Responses during Head-Up Tilt Test in Multiple Sclerosis Patients

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