The Bidirectional Relationship between Sleep and Neurodegeneration: Actionability to Improve Brain Health

Ibrahim, Abubaker; Högl, Birgit; Stefani, Ambra

doi:10.3390/ctn8010011

Cited by 2 publications

(1 citation statement)

References 72 publications

(76 reference statements)

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“…Disturbances in rhythmicity correlate with disease risk and severity ( Fishbein et al, 2021 ) in a bidirectional manner. This has been validated for numerous pathologies, including immune ( Liu et al, 2017 ; Shivshankar et al, 2020 ; Awuah et al, 2023 ), cardiovascular ( Gottlieb et al, 2019 ; Hayter et al, 2021 ), psychiatric ( Wehr et al, 1987 ; Meyer et al, 2024 ; Scheer and Chellappa, 2024 ), and neurodegenerative disorders ( Fernández-Arcos et al, 2019 ; Sharma et al, 2020 ; Ibrahim et al, 2024 ). Given this wide reach, investigating the circadian dimension of disease is imperative.…”

Section: Research Needsmentioning

confidence: 99%

Flight to insight: maximizing the potential of Drosophila models of C9orf72-FTD

d’Almeida,

Tipping

2024

Front. Mol. Neurosci.

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Advancements in understanding the pathogenesis of C9orf72-associated frontotemporal dementia (C9orf72-FTD) have highlighted the role of repeat-associated non-ATG (RAN) translation and dipeptide repeat proteins (DPRs), with Drosophila melanogaster models providing valuable insights. While studies have primarily focused on RAN translation and DPR toxicity, emerging areas of investigation in fly models have expanded to neuronal dysfunction, autophagy impairment, and synaptic dysfunction, providing potential directions for new therapeutic targets and mechanisms of neurodegeneration. Despite this progress, there are still significant gaps in Drosophila models of C9orf72-FTD, namely in the areas of metabolism and circadian rhythm. Metabolic dysregulation, particularly lipid metabolism, autophagy, and insulin signaling, has been implicated in disease progression with findings from animal models and human patients with C9orf72 repeat expansions. Moreover, circadian disruptions have been observed in C9of72-FTD, with alterations in rest-activity patterns and cellular circadian machinery, suggesting a potential role in disease pathophysiology. Drosophila models offer unique opportunities to explore these aspects of C9orf72-FTD and identify novel therapeutic targets aimed at mitigating neurodegeneration.

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Section: Research Needsmentioning

confidence: 99%

Flight to insight: maximizing the potential of Drosophila models of C9orf72-FTD

d’Almeida,

Tipping

2024

Front. Mol. Neurosci.

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Temporal progression of sleep electroencephalography features in isolated rapid eye movement sleep behaviour disorder

Angerbauer,

Stefani,

Zitser

et al. 2024

Journal of Sleep Research

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SummaryPrevious studies indicated that patients with isolated rapid eye movement (REM) sleep behaviour disorder (iRBD) exhibit alterations in spectral electroencephalographic (EEG), spindle, and slow‐wave features. As it is currently unknown how these EEG features evolve over time, this study aimed to evaluate their temporal progression in patients with iRBD in comparison to controls. We included 23 patients with iRBD and 23 controls. Two polysomnographies (baseline and follow‐up) were recorded with a mean (standard deviation) interval of 4.0 (2.5) years and were automatically analysed for sleep stages, spectral bandpower, spindles, and slow waves. We used linear models to evaluate differences at each time point, and linear mixed‐effects models to analyse differences in temporal progression between the groups. At baseline, patients with iRBD presented EEG slowing both in REM (expressed as significantly reduced α‐bandpower and increased δ‐bandpower in frontal channels) and in non‐REM (NREM) sleep (significantly increased slow‐to‐fast ratio in central channels). These differences vanished at follow‐up. In both REM and NREM sleep, γ‐bandpower was increased at follow‐up in patients with iRBD, resulting in significantly different temporal progression between groups (in occipital channels during REM sleep and frontal channels during NREM sleep). Relative power of sleep spindles was significantly higher at baseline in patients with iRBD in frontal channels, but we observed a significant reduction over time in central channels. Finally, slow waves were significantly shorter in patients with iRBD at both time‐points. Our results underscore the need of considering longitudinal data when analysing sleep EEG features in patients with iRBD. The observed temporal changes as markers of progression of neurodegeneration require further investigations.

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The Bidirectional Relationship between Sleep and Neurodegeneration: Actionability to Improve Brain Health

Cited by 2 publications

References 72 publications

Flight to insight: maximizing the potential of Drosophila models of C9orf72-FTD

Flight to insight: maximizing the potential of Drosophila models of C9orf72-FTD

Temporal progression of sleep electroencephalography features in isolated rapid eye movement sleep behaviour disorder

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