Analysis of risk factors for mild cognitive impairment based on word list memory test results and questionnaire responses in healthy Japanese individuals registered in an online database

Abstract

Although the development of effective therapeutic drugs and radical treatment options for dementia and Alzheimer’s disease (AD) remains urgent, progress in recent clinical trials of AD drugs has been less than adequate. In order to advance the progress of clinical trials, it is necessary to establish more efficient methods of recruitment. In Japan, there are registration systems stratified by mild cognitive impairment and preclinical and clinical stages of early and advanced stage dementia, but there is no registration system for healthy individuals yet. Therefore, in the present study, we developed a large-scale, internet-based health registry to investigate factors associated with cognitive function among registered participants. A total of 1038 participants completed the initial questionnaire and word list memory test. Among these participants, 353 individuals completed a second questionnaire and memory test. Stepwise multiple regression analysis was performed using IBM SPSS version 23.0 for Windows at a statistical significance level of p<0.05. We found that mood, motivation, and a decreased ability to perform activities of daily living were significantly associated with cognitive function. The results of the present study suggest that maintaining social involvement is important to prevent decreases in physical activity, daily function, mood, and motivation.

Subjective and Objective Mental and Physical Functions Affect Subjective Cognitive Decline in Community-Dwelling Elderly Japanese People

“…However, almost all recent clinical trials of drugs aimed at treating AD have been unsuccessful [ 3 ]. Hence, until effective therapeutic agents are developed, it is important to elucidate the risk factors for dementia onset and adopt interventions, where possible, to change lifestyle and individual patient’s characteristics [ 4 ]. In recent years, to prevent and delay the progression of pathological cognitive decline in older adults, it has been recommended that intervention be initiated at an early stage of AD, such as at the preclinical phase [ 5 ].…”

Longitudinal analysis of risk factors for dementia based on Mild Cognitive Impairment Screen results and questionnaire responses from healthy Japanese individuals registered in an online database

“…The same analysis using linear mixed-effect model identified a question “Are you basically satisfied with your life?” as a contributing factor. The question belonged to the category of “mood.” A cross-sectional study using registry data from the IROOP® [6] identified mood as one of the contributing factors toward cognitive functions. Because social involvement inhibits the development of depression [19] , social engagements and presence of friends to call, in the present study, indicate the presence of social connections, inhibiting the development of depression and acting as a protective factor against cognitive decline.…”

“…To date, risk factors for dementia have been identified and discussed previously. We reported that the maintenance of mood, motivation, and basic activities of daily living, and so forth contribute to preventing cognitive decline for a short interval of 6 months [6] . We also advised against the hasty consideration of differences among study results and highlighted the need for further data and continuous monitoring.…”

“…Until the availability of therapeutic or disease-modifying drugs for AD, the pressing issues include investigating risk factors for dementia and performing interventions to correct modifiable risk factors. In Japan, a large-scale registry system had not targeted healthy adults until we created the Integrated Registry of Orange Plan (IROOP®) [6] , a large-scale Internet-based registry system, to facilitate the smooth recruitment of participants in clinical trials focused on secondary prevention. The IROOP® is operated for identifying risk factors for dementia that are applicable to primary and secondary prevention.…”

Aktivitas Bermain Domino Sebagai Media Untuk Meningkatkan Kemampuan Fungsi Kognitif Berhitung Pada Lansia

“…Penyakit degeneratif pada lansia terdiri dari beberapa jenis, salah satunya adalah kerusakan saraf otak atau penurunan kognitif (pikun). Berdasarkan penelitian Ogawa, et al (2018) yang dilakukan pada 483 lansia dari usia 60-89 tahun menunjukkan bahwa semakin meningkatnya umur lansia maka fungsi kognitifnya akan semakin menurun.…”