Analysis of Risk Factors Associated with the Development of Hepatocellular Carcinoma in Chronic HBV-Infected Chinese: A Meta-Analysis

Lyu, Xiang; Liu, Kui; Chen, Yongdi; Wang, Zhifang; Yao, Jun; Cai, Guanqiang; Jiang, Zhenggang; Wang, Zhengting; Jiang, Jianmin; Gu, Hongtao

doi:10.3390/ijerph13060604

Cited by 13 publications

(17 citation statements)

References 28 publications

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“…Our study also showed that older age, cirrhosis, lower baseline HBV DNA levels, and AFP level 8 ng/mL at 12 months of treatment were independent factors of HCC. Surprisingly, our study showed that a lower baseline HBV DNA level was independently associated with HCC, which was in contradiction to a previous study [22]. The possible reason was that patients with cirrhosis had lower baseline HBV DNA than non-cirrhotic patients (7.02 ± 0.72 versus 7.32 ± 0.73, p < 0.001), and cirrhosis attributed as a major factor for HCC development.…”

Section: Discussioncontrasting

confidence: 99%

Comparison of the efficacy and safety of entecavir and tenofovir in nucleos(t)ide analogue-naive chronic hepatitis B patients with high viraemia: a retrospective cohort study

Hung

et al. 2017

Clinical Microbiology and Infection

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Section: Discussioncontrasting

confidence: 99%

Comparison of the efficacy and safety of entecavir and tenofovir in nucleos(t)ide analogue-naive chronic hepatitis B patients with high viraemia: a retrospective cohort study

Hung

et al. 2017

Clinical Microbiology and Infection

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“…The pronounced replication of HBV during CHB has been linked to the development of cirrhosis and hepatocellular carcinoma [23, 24]. Notably, this replication also seems to be affected by host factors.…”

Section: Discussionmentioning

confidence: 99%

Positive association between serum apolipoprotein M levels and hepatitis B virus DNA load in HBeAg-negative chronic hepatitis B

Shen

et al. 2016

Lipids Health Dis

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BackgroundHepatitis virus B (HBV) has infected millions of people worldwide. Notably, such infections can be associated with hepatic complications. Levels of apolipoprotein M (apoM), a component of high-density lipoprotein (HDL), are known to be significantly elevated in patients with chronic hepatitis B (CHB). The aim of this study was to investigate the relationship between HBV DNA load in serum and serum apoM levels in patients with CHB.MethodsA total of 73 HBeAg-negative CHB patients, 50 HBeAg-positive CHB patients, and 79 non-CHB controls were included in the study cohort. The age and body mass index (BMI) of the study participants were matched. Serum levels of apoM and the HBV antigens HBsAg and HBeAg were measured by enzyme-linked immunosorbent assay (ELISA) analysis. Serum levels of alanine aminotransferase (ALT), aspartate transaminase (AST), cholesterol, and triglycerides (TG) were assessed using an automatic biochemical analyzer. Serum HBV DNA levels were quantified by real-time PCR analysis. Data were analyzed by Spearman’s rank correlation coefficient, Pearson correlation coefficient, and multivariate linear regression model (continuous variables), or Student’s t-test (mean differences).ResultsBoth the HBeAg-negative CHB and HBeAg-positive CHB patient groups exhibited elevated serum levels of apoM. Moreover, serum apoM levels were positively correlated with serum HBV DNA levels in HBeAg-negative CHB patients (r = 0.394, p < 0.001). Conversely, there was no significant relationship between apoM and HBV DNA levels in the HBeAg-positive CHB group (r = 0.197, p = 0.170). The median log copies/mL value for HBV DNA (4.00) was considered the cutoff point for the HBeAg-negative CHB group. Notably, a significant number of patients with HBV DNA levels above the cutoff point also had higher serum apoM levels (63.38 ± 29.84 vs. 41.41 ± 21.84; p = 0.001).ConclusionsOur findings reveal that the correlation between serum apoM levels and viral loads may depend on HBeAg status, as serum apoM levels were positively correlated with HBV DNA levels in HBeAg-negative CHB patients. These results suggest that HBeAg may play a role in apoM-related lipid metabolism and anti-inflammatory functions in hepatitis B patients. Thus, our findings may facilitate the clinical management of HBV infection.

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“…Our meta-analysis also demonstrated that, for CHB patients, drinking alcohol and cigarette smoking could signifi cantly increase the risk of LC development. These fi ndings also were confi rmed by a meta-analysis of risk factors for development of HCC in similar subjects [39]. This result hinted that banning drink alcohol and cigarette smoking could decrease the number of LC development.…”

Section: Discussionmentioning

confidence: 53%

Meta-Analysis of Risk Factors for Development of Liver Cirrhosis in Chronic Hepatitis B Patients

Cai¹,

Chen²,

Li³

et al. 2018

Glob J Infect Dis Clin Res

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Chronic hepatitis B virus (HBV) infection and chronic hepatitis C virus (HCV) are main reasons for the development of liver cirrhosis (LC) on a worldwide scale. Chronic HBV infection is a main reason for the development of LC in high-risk areas, for example, China and Africa, whereas chronic HCV infection is a main reason in developed countries. In China, the harm of LC is serious, and 30 million of chronic hepatitis B (CHB) patients is the major source of LC and the one-year cumulative incidence rate of LC in CHB patients was 2.1%-6%. The risk factors of the development of LC in CHB patients reported were controversial. Therefore, we took CHB as participants, and we searched for studies in Chinese Medical Journal Database, Pubmed, Elsevier, Springer, Wiley, OVID, and EBSCO via BoKu data service platform, and did a meta-analysis and evaluated whether those published risk factors changed the development risk of LC. Both odds ratio (OR) and mean difference (MD) with 95% confi dence intervals (CI) were calculated by Review Manager 5.0. In this meta-analysis, 2928cases and 6530controls from 29 studies were analyzed. The pooled OR with 95% CI for 5 factors analyzed were: drinking alcohol 1.32 (1.11, 1.59), cigarette smoking 1.26 (1.04, 1.52), hepatitis B e antigen (HBeAg) seropositivity 0.42 (0.19, 0.94), a family history of hepatitis B 1.95 (1.05, 3.62), and male gender 1.33 (1.08, 1.65), respectively. And the pooled MD with 95% CI for 6 factors analyzed were: serum aspartate aminotransferase/alanine aminotransferase (AST/ALT) ratio 0.29(0.18,0.39), serum total bilirubin (TBil) levels 8.25(5.58,10.92)umol/L, duration of hepatitis B 2.68(2.21,3.15) years, age 7.37(4.60,10.14)years, serum alpha fetoprotein (AFP) levels-0.91(-16.04,14.22) ug/L, and serum HBV DNA levels 0.37 (-0.28, 1.02)copies/ml, respectively. In CHB patients, habits of drinking alcohol and cigarette smoking, elevated serum levels of TBil and serum AST/ALT ratio, increased duration of hepatitis B, a family of hepatitis B, male gender and older age can increase the risk of LC development.

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Analysis of Risk Factors Associated with the Development of Hepatocellular Carcinoma in Chronic HBV-Infected Chinese: A Meta-Analysis

Cited by 13 publications

References 28 publications

Comparison of the efficacy and safety of entecavir and tenofovir in nucleos(t)ide analogue-naive chronic hepatitis B patients with high viraemia: a retrospective cohort study

Comparison of the efficacy and safety of entecavir and tenofovir in nucleos(t)ide analogue-naive chronic hepatitis B patients with high viraemia: a retrospective cohort study

Positive association between serum apolipoprotein M levels and hepatitis B virus DNA load in HBeAg-negative chronic hepatitis B

Meta-Analysis of Risk Factors for Development of Liver Cirrhosis in Chronic Hepatitis B Patients

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