Analysis of risk factor and clinical characteristics of angiodysplasia presenting as upper gastrointestinal bleeding

Abstract

Background/Aims:Angiodysplasia is important in the differential diagnosis of upper gastrointestinal bleeding (UGIB), but the clinical features and outcomes associated with UGIB from angiodysplasia have not been characterized. We aimed to analyze the clinical characteristics and outcomes of angiodysplasia presented as UGIB.Methods:Between January 2004 and December 2013, a consecutive series of patients admitted with UGIB were retrospectively analyzed. Thirty-five patients with bleeding from angiodysplasia were enrolled. We compared them with an asymptomatic control group (incidental finding of angiodysplasia in health screening, n = 58) and bleeding control group (simultaneous finding of angiodysplasia and peptic ulcer bleeding, n = 28).Results:When patients with UGIB from angiodysplasia were compared with the asymptomatic control group, more frequent rates of nonantral location and large sized lesion (≥ 1 cm) were evident in multivariate analysis. When these patients were compared with the bleeding control group, they were older (mean age: 67.94 ± 9.16 years vs.55.07 ± 13.29 years, p = 0.03) and received less transfusions (p = 0.03). They also had more frequent rate of recurrence (40.0% vs. 20.7%, p = 0.02).Conclusions:Non-antral location and large lesions (≥ 1 cm) could be risk factors of UGIB of angiodysplasia. UGIB due to angiodysplasia was more common in older patients. Transfusion requirement would be less and a tendency of clinical recurrence might be apparent.

A Risk Assessment of Factors for the Presence of Angiodysplasias During Endoscopy and Factors Contributing to Symptomatic Bleeding and Rebleeds

“…Thirteen studies assessed risk factors for the presence of angiodysplasias detected during endoscopy (Table 1, 2) [15, 28–39, 41]. Nine studies (Table 1) assessed risk factors for the presence of angiodysplasias in patients with overt or occult gastrointestinal bleeding compared to patients without angiodysplasias and bleeding.…”

Angiodysplasia of the Gallbladder: An Unknown Risk Factor for Cholecystolithiasis

“…This type of lesion occurs at higher frequencies in patients with aortic stenosis, cirrhosis, pulmonary disease, renal failure, and von Willebrand's disease [ 2 ]. The most common site is the colon in the lower gastrointestinal tract or the stomach and duodenum in the upper gastrointestinal tract [ 5 , 8 ]. Except for the gallbladder, which is an extremely rare site of angiodysplasia, cases of the appendix, minor papilla, and proximal bile duct are also described in the literature [ 9 – 11 ].…”

Recurrence of Multiple Gastrointestinal Angioectasias Despite Treatment with Argon Plasma Coagulation Requiring Thalidomide Treatment in a Patient with Cirrhosis: A Rare Case Report

“…Variceal bleeding accounts for a high percentage of bleeding episodes overall in individuals with cirrhosis (approximately 80%). Dae Bum et al reported angiodysplasias in association with aortic valve disease, systemic sclerosis, hereditary hemorrhagic telangiectasia and in patients with end-stage renal disease [10-12].…”