Angiodysplasia of the Gallbladder: An Unknown Risk Factor for Cholecystolithiasis

Švagelj, Ivan; Vučko, Mirta; Hrskanović, Mato; Švagelj, Dražen

doi:10.1155/2020/7192634

Cited by 4 publications

(13 citation statements)

References 8 publications

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“…The incidence rate of gallstone is rising because of the change of living standard. However, 8%~25% of patients have choledocholithiasis, which may lead to serious complications if effective treatment is not taken in time [ 4 , 5 ]. However, the treatment of cholecystolithiasis combined with common bile duct stones is more difficult.…”

Section: Introductionmentioning

confidence: 99%

Effect of Microscope Combined with Wechat Smart Platform on Clinical Efficacy and Gastrointestinal Function of Patients with Cholecystolithiasis Combined with Common Bile Duct Stones

Guo

Zhang

et al. 2022

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To explore the clinical efficacy of microscope combined with Wechat smart platform in patients with cholecystolithiasis and choledocholithiasis, this paper proposes the effect of microscope combined with Wechat smart platform intervention after laparoscopic lithotomy and choledocholithotomy on the clinical efficacy and gastrointestinal function of patients with cholecystolithiasis combined with choledocholithiasis. From February 2018 to March 2019, 78 patients with gastric cancer were selected by our clinic and included in the research team. Evaluate the efficacy of endoscopic biliary lithotomy (LBL) + bile duct lithotomy (TBL) + T-tube drainage therapy to provide reliable evidence for improved efficacy and efficacy in order to provide a strong reference for improving the effectiveness and safety of surgical treatment of choledocholithiasis. Safety of surgical treatment of diseases. Gallstone disease. The experiments did not show any significant differences between the two groups during surgery. Diabetes was lower in the control group, and hospital incidence was lower in the control group. There were no significant differences between the two groups for preoperative WHOQOL-100 scores. Two weeks and four weeks after surgery, the man-key-100 score was higher than that of the control group. Endoscopic cholecystectomy + choledocholithotomy + choledochoscopic lithotomy + T-tube fluid have been shown to be effective in promoting rapid intestinal function and improving patient quality of life and are appropriate for therapeutic use.

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Section: Introductionmentioning

confidence: 99%

Effect of Microscope Combined with Wechat Smart Platform on Clinical Efficacy and Gastrointestinal Function of Patients with Cholecystolithiasis Combined with Common Bile Duct Stones

Guo

Zhang

et al. 2022

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“…What causes gallstones concomitant with gallbladder angiodysplasia? To answer this question Ivan et al [11] hypothesized that vascular abnormalities in the gallbladder can deform the muscular wall, resulting in decreased motility, which can be involved in the development of gallstones. Consequently, Ivan et al proposed that gallbladder angiodysplasia could be a risk factor for the development of cholelithiasis in younger female patients, and may even be the primary cause.…”

Section: Discussionmentioning

confidence: 99%

Gallbladder angiodysplasia: a literature review

Rehman,

Salehi,

Lorraine Co

et al. 2023

International Journal of Surgery: Global Health

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Introduction: Angiodysplasia is a vascular lesion responsible for 6% of lower gastrointestinal bleeding cases. It is generally located in the cecum and ascending colon in elderly patients. Angiodysplasia of the gallbladder is a rare condition. The main objective of this literature review was to summarize the demographics, clinical signs and symptoms, gross findings, histopathology, immunohistochemistry, treatment, and follow-up of patients with gallbladder angiodysplasia. Methods and materials: The authors searched PubMed, ScienceDirect, and Google Scholar using relevant keywords. The search was performed in line with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, using appropriate keywords. The case reports included were those dealing exclusively with human subjects, were published in the English language, and had free, full-text, public access. Data was extracted and case reports were evaluated. Results: Of the 1097 studies initially identified, 3 (0.27%) were analyzed. There were two females (66.6%) and one male (33.3%). The mean age of presentation was 47.6 years. The most common presenting complaint was colicky right upper abdominal pain in two cases (66.6%). Elective cholecystectomy was performed in only two cases (66.6%). In one case (33.3%), petechiae were diffusely present in the gastric mucosa and patchy in the gallbladder, duodenum, jejunum, ileum, cecum, and ascending colon on autopsy. Histopathological findings were consistent with gallbladder angiodysplasia in all three cases (100%). On immunohistochemistry CD-34, CD-31, and D2-40 were positive in only one case. Conclusions: Despite conflicting data, histological and immunohistochemical analyses play major roles in the diagnosis of gallbladder angiodysplasia. Nonetheless, further clinical studies are required to provide universal guidelines for the treatment and diagnosis of angiodysplasia of the gallbladder.

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“…Vessels are indispensable, integrative structures of all tissues 1. Therefore, vessel malformations are the cause of many pathological situations 1.…”

Section: Introductionmentioning

confidence: 99%

“…Vessels are indispensable, integrative structures of all tissues 1. Therefore, vessel malformations are the cause of many pathological situations 1. Angiodysplasia is characterised by abnormally dilated submucosal and mucosal blood vessels, which are lined with normal endothelium and surrounded by scant or no smooth muscle but without correlation with hereditary, skin or systemic disease 1 2.…”

Section: Introductionmentioning

confidence: 99%

“…Therefore, vessel malformations are the cause of many pathological situations 1. Angiodysplasia is characterised by abnormally dilated submucosal and mucosal blood vessels, which are lined with normal endothelium and surrounded by scant or no smooth muscle but without correlation with hereditary, skin or systemic disease 1 2. Angiodysplasia of the gastrointestinal (GI) tract is a common cause of occult GI bleeding (GIB).…”

Section: Introductionmentioning

confidence: 99%

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Rare cause of obstructive haemobilia with recurrent biliopancreatic complications: a paradigmatic case

et al. 2022

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Haemobilia is an unusual but significant cause of upper gastrointestinal bleeding. Two-thirds of haemobilia cases are secondary to invasive hepato-biliopancreatic procedures. Biliary angiodysplasia is exceptionally unusual, with only three cases reported. Herein, we report the case of an autonomous 80-year-old woman with a history of cholecystectomy 5 years ago and cardiovascular disease—hypertension, heart failure, acute myocardial infarction, stroke and non-valvular atrial fibrillation, anticoagulated with apixaban 2.5 mg two times per day. Since July 2019, she had four episodes of acute cholangitis of mild-to-moderate severity, having undergone broad spectrum antibiotics treatment and endoscopic retrograde cholangiopancreatography (ERCP), with sphincterotomy and bile sludge extraction. After 3 months, the patient presented with a new episode of acute cholangitis, this time with haemobilia (Quincke’s triad). An abdominal CT angiography showed no evidence of active bleeding, with plastic biliary prosthesis left by ERCP. The patient continued presenting new episodes of acute cholangitis with haemobilia, some of them with associated pancreatitis. A cholangioscopy with Spyglass DS II was performed, showing an angiodysplasia occupying half of the luminal circumference of the middle choledoccus, without active haemorrhage. After a multidisciplinary meeting and given the high haemorrhagic/thrombotic risk (CHA2DS2-VASc 8), closure of the left atrial appendage was considered. However, relapse of the condition after beginning the antiaggregation protocol for cardiovascular intervention made it unfeasible. Another cholangioscopy with an ultra-thin endoscope for argon-plasma coagulation was attempted, without success. The abdominal CT angiography was repeated, this time with identification of dilated ramifications of the gastroduodenal and inferior pancreatic arteries. After embolisation of these aberrant vessels with microcoils, the patient went well, with no recurrence of bleeding or biliopancreatic complications. We present a case of obstructive haemobilia with multiple biliopancreatic complications, secondary to an extremely rare cause—choledochal angiodysplasia. Cholangioscopy had a decisive role in the diagnosis and therapeutic guidance. The diagnostic/therapeutic challenge associated with haemobilia stands out, with the need for a personalised and multidisciplinary approach.

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Angiodysplasia of the Gallbladder: An Unknown Risk Factor for Cholecystolithiasis

Cited by 4 publications

References 8 publications

Effect of Microscope Combined with Wechat Smart Platform on Clinical Efficacy and Gastrointestinal Function of Patients with Cholecystolithiasis Combined with Common Bile Duct Stones

Effect of Microscope Combined with Wechat Smart Platform on Clinical Efficacy and Gastrointestinal Function of Patients with Cholecystolithiasis Combined with Common Bile Duct Stones

Gallbladder angiodysplasia: a literature review

Rare cause of obstructive haemobilia with recurrent biliopancreatic complications: a paradigmatic case

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