Analysis of results of volatile organic compound (VOC) measurements using breathanalyzer on COVID-19 confirmed patients with pneumonia and without pneumonia

Abstract

WHO declared COVID-19 infection as a pandemic since 2020. A rapid noninvasive examination is needed for screening and diagnostic. Exhaled Volatile Organic Compound (VOC) is a sample directly connected to the affected organ, which is the lung, and can be measured as an endogenous volatile marker resulted from oxidative stress. This study aims to analyze differences in VOC concentration in COVID-19 patients with pneumonia and without pneumonia. This Case Control Study used 93 confirmed case samples of COVID-19 and 42 healthy subject. Demographic and clinical data taken from anamnesis and/or medical records. VOC’s data of respiratory track are taken through the exhalation air in a bag and analyzed with breathanalyzer. Statistical analysis was conducted using Mann-Whitney test. In the analysis of confirmed samples of COVID-19 between pneumonia and without pneumonia, co components were found to affect the incidence of pneumonia in confirmed samples of COVID-19 (p=0.003). This conclusion is Components of CO in confirmed COVID-19 have a meaningful effect on an event of pneumonia.

Results of Analysis of Volatile Organic Compound (VOC) Measurements Using Breath Analyzer on Coronavirus Disease 2019 (COVID-19) Confirmed Patients with Healthy People

“…Patient confirmed COVID-19 with pneumonia and without pneumonia differences in VOC results. There was an increase in the CO, NH4 and Acetone components in confirmed samples of COVID-19 with pneumonia, and a decrease in the components in CO2 and TVOC in samples confirmed for COVID-19 accompanied by pneumonia [6]. Hypertension is one of the most common comorbidities in COVID-19 patients.…”

“…When people are infected with SARS-CoV-2, characteristic protein and metabolite changes are observed; and more than 100 lipids have been reported to be down-regulated in their blood sera [5]. VOC's data of respiratory track are taken through the exhalation air in a bag and analyzed with breath analyzer [6]. In this study, profiling and analysis of Volatile Organic Compound (VOC) using a breathanalyzer will be carried out in patients diagnosed with Covid-19 and healthy people.…”