Analysis of quantitative changes in hair growth during treatment with chemotherapy or tamoxifen in patients with breast cancer: a cohort study

Kanti, Varvara; Nuwayhid, R.; Lindner, Judith; Hillmann, Kathrin; Stroux, Andrea; Bangemann, Nikola; Kleine-Tebbe, A.; Blume-Peytavi, Ulrike; Bartels, Natalie Garcia

doi:10.1111/bjd.12716

Cited by 32 publications

(44 citation statements)

References 36 publications

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“…On the other hand, it has to be considered that the fronto-parietal scalp is covered with a comparatively high amount of hair follicles in the anagen phase extremely sensible to toxic effects of cytostatics [23].…”

Section: Discussionmentioning

confidence: 99%

The Influence of Various Parameters on the Success of Sensor-Controlled Scalp Cooling in Preventing Chemotherapy-Induced Alopecia

et al. 2015

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Background: The influence of systemic comorbidities on the success of scalp cooling during chemotherapy (CT) is widely unexplored. Comorbidities often require additional medication which itself can occasionally cause alopecia. This study investigates the influence of selected parameters on the efficacy of scalp cooling for the prevention of CT-induced alopecia. Patients and Methods: 226 cancer patients were treated with various CT regimens in combination with sensor-controlled scalp cooling. 136 breast cancer patients received (neo)adjuvant therapy, and 76 of these patients received epirubicine and cyclophosphamide (4× EC 3w) followed by paclitaxel (12× T w). The following parameters were prospectively investigated: chemotherapy-induced alopecia, systemic comorbidities and co-medication, nicotine abuse, hair treatment, menopausal status, and trichologic status. Results: Scalp cooling was successful (no or not visible hair loss; common toxicity criteria 0-1) in 65% of all patients, in 65% of the 136 breast cancer patients, and in 68% of the 76 patients receiving EC/T. In this subgroup, premenopausal patients (p = 0.009) and those without systemic comorbidities (p = 0.003), without co-medication (p < 0.001) and with high hair density (p = 0.038) showed less hair loss during CT; an effect was also seen for nicotine abuse (p = 0.023). Hair length and hair treatment had no significant influence. Conclusion: Sensor-controlled scalp cooling represents an effective addition to supportive cancer therapy. The success of scalp cooling depends on the applied CT regimen. Parameters like menopausal status, systemic comorbidities, medication, nicotine abuse, and original hair density also influence the outcome of hair loss prevention.

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Section: Discussionmentioning

confidence: 99%

The Influence of Various Parameters on the Success of Sensor-Controlled Scalp Cooling in Preventing Chemotherapy-Induced Alopecia

et al. 2015

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“…UV exposure, aging, nutritional deficiencies, morbidity, medication use, and acute metal poisoning has been described to cause natural deterioration and hair structural changes that affect the ability of hair to retain elements [14,36,37]. Specifically in disease, the levels of elements in the body may not be optimal and indirectly affect hair growth and hence hair structure.…”

Section: Hair Elemental Uptake Mechanisms and Factors That Affect Haimentioning

confidence: 99%

Ion Beam, Synchrotron Radiation, and Related Techniques in Biomedicine: Elemental Profiling of Hair

Cloete¹

2018

Accelerator Physics - Radiation Safety and Applications

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Elements play an imperative role in the physiological and metabolic processes of the human body. When elemental levels deviate from physiologically accepted levels due to for example poor nutrition, the body's intricate elemental and metabolic balance is disturbed. Over time, disease may develop as a result of elemental dyshomeostasis or alternatively, disease may trigger elemental dyshomeostasis as an adaptive metabolic response to an unhealthy environment. There is now a growing interest in screening human tissue to identify and quantify elemental changes as biomarkers of disease or alternatively, as outcomes of disease. The unique properties of human hair brand it the ideal substrate for the quantitative identification of elements in the body. Hair bioaccumulates elements, provides a historical overview of elemental status depending on length, and is easy and economical to sample and store. The fundamental outcome and application of hair elemental screening, however, are strongly influenced by a range of factors, including choice of analytical method. This chapter will provide a background summary of ion beam and synchrotron radiation techniques and its diverse applications for unraveling the elemental signature of hair in various fields.

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“…Sie tritt auf, wenn die metabolische und mitotische Aktivität des Follikelepithels plötzlich unterdrückt wird [27,28]. Die am häufigsten mit Anageneffluvium assoziierten Chemotherapeutika sind Cyclophosphamid, Ifosfamid, Mechlorethamin, Daunorubicin, Idarubicin, Paclitaxel, Docetaxel, Topotecan, Irinotecan, Etoposid, Vincristin, Actinomycin D, Gemcitabin und Busulfan.…”

Section: Anageneffluviumunclassified

“…3). Innerhalb von 3 Monaten nach Beendigung der Chemotherapie beginnt das Haar wieder zu wachsen [28]. Die Behandlung umfasst zunächst die Identifizierung und Therapie der zugrunde liegenden Ursache.…”

Section: Anageneffluviumunclassified

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Alopezien infolge von Medikamenten oder von anderen Haut- und systemischen Erkrankungen

Guzmán-Sánchez¹,

Asz-Sigall²

2016

Kompass Dermatol

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In diesem Kapitel werden die häufigsten Formen der Alopezie vorgestellt, die durch medikamentöse Therapien oder durch andere Hautkrankheiten und systemische Erkrankungen hervorgerufen werden können. Die folgenden Haarerkrankungen werden analysiert: das Telogeneffluvium (akut und chronisch); das Anageneffluvium; die follikulotrope Mycosis fungoides sowie Follikulitiden infolge von Bakterien, Pilzen, Parasiten, humanem Immundefizienzvirus, Lupus erythematodes und Sarkoidose. Dabei werden die Epidemiologie und Ätiologie, die klinische Manifestation und Diagnose sowie die aktuellen Therapien der einzelnen Krankheiten abgedeckt.

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Analysis of quantitative changes in hair growth during treatment with chemotherapy or tamoxifen in patients with breast cancer: a cohort study

Cited by 32 publications

References 36 publications

The Influence of Various Parameters on the Success of Sensor-Controlled Scalp Cooling in Preventing Chemotherapy-Induced Alopecia

The Influence of Various Parameters on the Success of Sensor-Controlled Scalp Cooling in Preventing Chemotherapy-Induced Alopecia

Ion Beam, Synchrotron Radiation, and Related Techniques in Biomedicine: Elemental Profiling of Hair

Alopezien infolge von Medikamenten oder von anderen Haut- und systemischen Erkrankungen

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