Analysis of Prognostic Factors in Patients with Resected Peripheral T1 Adenocarcinoma of the Lung

Lima, Cláudio F.; Matsui, Kazuhiro; Kitagawa, Maki; Mizushima, Yutaka; Noto, Hirofumi; Miwa, Atsuo

doi:10.1016/s0344-0338(11)80837-x

Cited by 5 publications

(7 citation statements)

References 18 publications

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“…A total of 35 studies fulfilled the criteria of selection (Zimmerman et al, 1987;Tirindelli-Danesi et al, 1987;Ten Velde et al, 1988;Volm et al, 1988;Yamaoka et al, 1989;Cibas et al, 1989;Dazzi et al, 1990;Isobe et al, 1990;Sahin et al, 1990;Shiota et al, 1990;Miyamato et al, 1991;Mizumoto et al, 1991;Liewald et al, 1992;Ogawa et al, 1992;Filderman et al, 1992;Morkve et al, 1993;Cheon et al, 1993;Pence et al, 1993;Rice et al, 1993;Ichinose et al, 1993;Lima et al, 1993;Shimizu et al, 1993;Yu et al, 1993;Usuda et al, 1994;Salvati et al, 1994;Tanaka et al, 1995;Pujol et al, 1996;Huang et al, 1996;Nagai et al, 1996;Jeanfaivre et al, 1997;Muguerza et al, 1997;Kolodzeijski et al, 1997;Graziano et al, 1997;Dalquen et al, 1997;Asamura et al, 1999; (Table 1)). Among the 4033 assessable patients, 2626 suffered from NSCLC with aneuploid DNA content (overall frequency of aneuploidy: 0.65; 95% Cl: (0.64-0.67)).…”

Section: Resultsmentioning

confidence: 99%

“…British Journal of Cancer (2001) Zimmerman;1987 Tirindelli;1987 Ten velde;1988 Volm;1988 Yamaoka;1989 Cibas;1989 Dazzi;1990 Isobe;1990 Sahin;1990 Shiota;1990 Miyamoto;1991 Mizumoto;1991 Liewald;1992 Ogawa;1992 Filderman;1992 Morkve;1993 Cheon;1993 Pence;1993 Rice;1993 Ichinose;1993 Yu;1993 Lima;1993 Shimizu;1993 Usuda;1994 Salvati;1994 Tanaka;1995 Pujol;1996 Huang;1996 Nagai;1996 Jeanfaivre;1997 Muguerza;1997 Kolodziejski;1997 Graziano;1997 Dalquen;1997 Asamura;1999 Overall iploidy better Aneuploidy better 0 0.5 1 1.5 2 2.5 3 3.5 4 4.5 5 I yr D…”

Section: Meta-analysis Of Ploidy In Nsclc 17mentioning

confidence: 99%

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Aneuploidy and prognosis of non-small-cell lung cancer: a meta-analysis of published data

Choma

Daurès²,

Quantin

et al. 2001

Br J Cancer

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Ploidy status predicts disease-free intervals and short-term survival in numerous human malignancies (Barlogie et al 1983; Friedlander et al 1984). In lung cancer, the prognostic value of ploidy is controversial. The effect of ploidy status on patient outcome has been investigated particularly in non-small-cell lung cancers (NSCLC), a group of different histologies including squamous cell carcinoma (SQC), adenocarcinoma (ADC) and large cell carcinoma (LCC). Although authors from different laboratories have suggested that patients presenting an aneuploid tumour have a shorter survival than patients presenting a nearly diploid tumour, others did not find such a difference. Many factors could explain the differences in estimating the ploidy-survival relationship. Possible interpretation could lie in the heterogeneity of the abnormal DNA patterns gathered under the common term of aneuploidy, i.e. hyperdiploidy, hypodiploidy and multiploidy . Differences in methods used to analyse DNA content could also have been responsible for the above-mentioned controversy inasmuch as some studies were founded on flow cytometry data whereas others used static cytometry. Finally, the difference might be related to the histological and clinical characteristics of the studied patient population.We therefore made a meta-analysis of published studies aimed at determining the prognostic effect of aneuploidy in surgically resected NSCLC. TRIALS AND METHODS Eligibility criteriaThe most conventional definition of ploidy status is as follows: ploidy was determined for each specimen using DNA index which represents the ratio of the cell DNA content of tumour G 0/1 cells to the diploid G 0/1 peak (2n). A coefficient of variation (CV) for this DNA index (DI) has been specifically defined for each study. Thus, a DNA index = 1 defined a near diploid specimen i.e. only one peak of G 0/1 cells in the near diploid region (2n, DNA index = 1) with few G 2 M tumour cells in the tetraploid region (4n Summary In lung cancer, DNA content abnormalities have been described as a heterogeneous spectrum of impaired tumour cell DNA histogram patterns. They are merged into the common term of aneuploidy and probably reflect a high genotypic instability. In non-small-cell lung cancer, the negative effect of aneuploidy has been a subject of controversy inasmuch as studies aimed at determining the survival-DNA content relationship have reported conflicting results. We made a meta-analysis of published studies aimed at determining the prognostic effect of aneuploidy in surgically resected non-small-cell lung cancer. 35 trials have been identified in the literature. A comprehensive collection of data has been constructed taking into account the following parameters: quality of specimen, DNA content assessment method, aneuploidy definition, histology and stage grouping, quality of surgical resection and demographic characteristics of the analysed population. Among the 4033 assessable patients, 2626 suffered from non-small-cell lung cancer with aneuploid DNA content ...

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Section: Resultsmentioning

confidence: 99%

Section: Meta-analysis Of Ploidy In Nsclc 17mentioning

confidence: 99%

Aneuploidy and prognosis of non-small-cell lung cancer: a meta-analysis of published data

Choma

Daurès²,

Quantin

et al. 2001

Br J Cancer

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“…Furthermore, when cases were divided by stage, the negative prognostic value of OPN expression was restricted to stage 1 cases 7,28 . In addition, histological grade per se is not universally accepted as an independent predictor of prognosis in lung adenocarcinoma 29,30 …”

Section: Discussionmentioning

confidence: 99%

“…7,28 In addition, histological grade per se is not universally accepted as an independent predictor of prognosis in lung adenocarcinoma. 29,30 We set out to study patterns of expression of OPN, cancer markers and MMPs in an effort to form a working hypothesis on their interactions and we took advantage of recently developed antibodies to the activated, phosphorylated forms of molecules involved in signalling pathways. However, we are aware that an immunohistochemical study cannot provide functional information and that our hypothesis awaits biochemical validation.…”

Section: Opn In MMmentioning

confidence: 99%

Osteopontin is linked to p65 and MMP‐9 expression in pulmonary adenocarcinoma but not in malignant pleural mesothelioma

Frey

Wali²,

Pass

et al. 2007

Histopathology

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“…37 Environment-Related Factors: A full description of therapeutic options and their efficacy is beyond our intended scope in this article. Medical decision making must consider at least two conditional prognoses (eg, the prognosis with one treatment and the prognosis with an alternative treatment), hence, the prognostic significance of a therapeutic intervention 10,80 "N" factor 46,[80][81][82] Weight loss 51,52 Hypercalcemia 54 Performance status 55 Additional factors Anatomic Sex 52 "T" factor 46,[83][84][85][86][87] Tumor size [88][89][90] Age 91,92 Nodal level 86,93 Pleural cytology 63,94,95 Intrapulmonary metastasis 96…”

Section: Tumor-related Factorsmentioning

confidence: 99%

Prognostic Factors in Non-small Cell Lung Cancer

Brundage

Davies

Mackillop

2002

Chest

515

334

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Analysis of Prognostic Factors in Patients with Resected Peripheral T1 Adenocarcinoma of the Lung

Cited by 5 publications

References 18 publications

Aneuploidy and prognosis of non-small-cell lung cancer: a meta-analysis of published data

Aneuploidy and prognosis of non-small-cell lung cancer: a meta-analysis of published data

Osteopontin is linked to p65 and MMP‐9 expression in pulmonary adenocarcinoma but not in malignant pleural mesothelioma

Prognostic Factors in Non-small Cell Lung Cancer

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