Analysis of prognostic factors in 1180 patients with oral cavity primary cancer treated with definitive or adjuvant radiotherapy

Murthy, Vedang; Agarwal, Jitendra; Laskar, Siddhartha; Gupta, Tejpal; Budrukkar, Ashwini; Pai, Prathamesh; Chaturvedi, Pankaj; Chaukar, Devendra; D’Cruz, Anil

doi:10.4103/0973-1482.73360

Cited by 60 publications

(46 citation statements)

References 18 publications

(19 reference statements)

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“…[17]. However, our cohort had over 75% of patients with T3–T4 disease on presentation, and over 85% with AJCC Stage III or greater, which may have masked the influence of most prognostic factors.…”

Section: Discussionmentioning

confidence: 98%

Definitive chemoradiation for primary oral cavity carcinoma: A single institution experience

et al. 2015

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Summary Objectives While surgery with or without adjuvant radiation therapy (RT) is the standard of care for oral cavity cancer (OCC), a select group requires nonsurgical treatment. We provide a single-institution experience using definitive chemotherapy and RT for primary OCC. Materials and methods We examined 73 patients with previously untreated, non-metastatic primary OCC treated definitively from 1990 to 2011. There were 39 male and 34 female, with a median age of 63 years (range, 35–89). The disease distribution was Stage I and II (7% each), Stage III (14%), and Stage IV (73%). Oral tongue was the most common (48%), followed by floor of mouth (19%), retromolar trigone (13.7%), and others (8.2%). Median tumor dose was 70 Gy. Sixty-two percent of patients (n = 45) were treated with concurrent chemotherapy, predominantly platinum-based. Results Median follow-up among surviving patients was 73.1 months (interquartile range 14.2– 81.4 months). Actuarial 5-year overall survival was 15%. Incidences of locoregional and distant failures were 41.1% and 20.5%, respectively. Kaplan-Meier estimated 5-year rates of locoregional control and freedom from distant metastasis were 37% and 70%, respectively. Mucositis was the most common ≥ Grade 3 acute toxicity (49%). Incidences of Grade 3 late dysphagia and trismus were 15% and 13%, respectively. Conclusion This study demonstrates over 20 years of experience using definitive chemoradiation for OCC at our institution. Our results illustrate the challenges in treating patients with advanced disease who are not surgical candidates, and the need for adequate and early treatment to prevent distant disease and improve survival outcomes.

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Section: Discussionmentioning

confidence: 98%

Definitive chemoradiation for primary oral cavity carcinoma: A single institution experience

et al. 2015

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“…Resultado semelhante foi encontrado em estudo de sobrevida de cinco anos que avaliou pacientes com carcinoma de células escamosas em língua (45,5% de sobrevida contra 96,1% em pacientes tratados cirurgicamente) 43 . A cirurgia é o principal tratamento para o câncer de boca, de forma exclusiva, ou em combinação com radioterapia e/ou quimioterapia 2,5,12,36,37,44 .…”

Section: Para Pacientes Diagnosticadosunclassified

“…A despeito dessas considerações e de que um dos mais importantes objetivos de um sistema de saúde é prover diagnóstico precoce e assistência oportuna a sua população, mais da metade dos casos tem sido diagnosticada em estágios avançados, o que implica em pior prognóstico e diminuição da taxa de sobrevida 1,2,3,7,8,9,10,11,12 . Sugerem-se diversas situações que poderiam levar a essa demora: profissionais que não sabem orientar corretamente pacientes; pacientes que não procuram o profissional por medo do diagnóstico ou somente o procuram quando já sofrem alguma restrição alimentar, de fala ou de convívio social 7,10,13 .…”

Section: Introductionunclassified

Sobrevida de cinco anos e fatores associados ao câncer de boca para pacientes em tratamento oncológico ambulatorial pelo Sistema Único de Saúde, Brasil

et al. 2014

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O objetivo foi analisar a sobrevida específica de cinco anos e fatores associados para câncer de boca no Brasil. Trata-se de coorte retrospectiva, cuja fonte de dados foi a Base Onco, que realizou o relacionamento probabilístico-determinístico de todos os registros de autorização para radioterapia e/ou quimioterapia pelo Sistema Único de Saúde, entre 2000 e 2006, gerando-se cadastro único para cada paciente. O presente estudo incluiu os pacientes diagnosticados entre 2002 e 2003 com câncer de boca, exceto lábio, e idade entre 19 e 100 anos (N = 6.180). A taxa de sobrevida específica em cinco anos foi de 60%. Foram associados à menor sobrevida específica: ter idade > 40 anos; apresentar estádio III ou IV; localização em língua, assoalho de boca e base de língua; não realizar tratamento cirúrgico, realizar somente quimioterapia ou radioterapia e quimioterapia e residir em determinados estados do Brasil. Os resultados reforçam a necessidade de incluir a avaliação das disparidades dos territórios de planejamento como possibilidade para incrementar as ações de saúde e melhorar os indicadores de sobrevida.

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“…Metastasis to neck node is the most important prognostic factor for oral cancer. Tumor size and T stage is another factor (Woolgar et al, 1995;Lee, 2005;Murthy et al, ????). In this study the T (p=0.02) and N (p=0.00) stage emerged as independent predictors of survival, which was in agreement with most published results (Montoro et al, 2008;Murthy et al, ????…”

Section: A) B) C) D) E) F)mentioning

confidence: 99%

Survival Following Non Surgical Treatments for Oral Cancer: a Single Institutional Result

Larizadeh

Shabani²

2012

Asian Pacific Journal of Cancer Prevention

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Analysis of prognostic factors in 1180 patients with oral cavity primary cancer treated with definitive or adjuvant radiotherapy

Abstract: The results indicate superior outcomes with PORT particularly in advanced stages of oral cancer and inferior outcomes in tongue and floor of mouth subsites. There is scope for improving outcomes by adopting treatment intensification strategies.

Cited by 60 publications

References 18 publications

Definitive chemoradiation for primary oral cavity carcinoma: A single institution experience

Definitive chemoradiation for primary oral cavity carcinoma: A single institution experience

Sobrevida de cinco anos e fatores associados ao câncer de boca para pacientes em tratamento oncológico ambulatorial pelo Sistema Único de Saúde, Brasil

Survival Following Non Surgical Treatments for Oral Cancer: a Single Institutional Result

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