Analysis of prognostic factors in soft tissue sarcoma: Cancer registry from a single tertiary hospital in Indonesia. A retrospective cohort study

Abstract

Background Soft tissue sarcoma is one cause of mortality in adult malignancies. This tumor is rare, persistent, and highly-recurrent. Many patients are came in late stage. It is important to identify a prognostic tool that is reliable, easily obtainable, and widely applicable. The aim of this study is to investigate and analyze the prognostic value of clinicopathological and biomarker factors in patients with soft tissue sarcoma. Methods This retrospective study extracts data from the musculoskeletal tumor registry from January 2012 to December 2018 in a single tertiary hospital. Eighty patients with diagnosis of soft tissue sarcoma were included. Preoperative modified Glasgow Prognostic Score, Neutrophils/Lymphocytes Ratio, Hemoglobin, serum lactate dehydrogenase data were analyzed along with demographic, clinical, radiological and histopathological data. The relationship between variables on overall survival, distant metastasis, and local recurrence were evaluated using univariate and multivariate Cox regression. Results On univariate analysis, there was significant relationship between hemoglobin, Neutrophils/Lymphocytes Ratio and modified Glasgow Prognostic Score with overall survival (p = 0.031, HR = 1.99; p = 0.04, HR = 1.129; and p = 0.044, HR = 3.89). A significant relationship was found between age and soft tissue sarcoma stage with distant metastasis (p = 0.046, HR = 1.95; and p = 0.00, HR = 3.22). In addition, we also found significant relationship between surgical margin with local recurrence (p = 0.018, OR = 3.44). However, on multivariate analysis the independent prognostic factor for overall survival was only modified Glasgow Prognostic Score (HR = 2.138; p = 0.011). Stage IIIA (HR = 5.32; p = 0.005) and IIIB (HR = 13.48; p = 0.00) were independent prognostic for distant metastasis. Surgical margin was independently associated with local recurrence (HR = 14.84; p = 0.001). Conclusion Modified Glasgow Prognostic Score can be used as prognostic tool of overall survival in soft tissue sarcoma patients. Moreover, stage of STS and surgical margin can be used as a prognostic factor for distant metastasis and local recurrence of soft tissue sarcoma respectively.

Prognostic value of pretreatment anemia in patients with soft tissue sarcoma

“…A total of 9 studies explored the relationship between pre-treatment anemia and the OS of patients with STS [14,21,22,24,26–29,41] . The pooled data shows that pre-treatment anemia is related to a poor OS (HR: 2.13, 95%CI: 1.52–2.98, P < .00001).…”

“…The prognostic value of pre-treatment anemia for OS/ DSS/DFS A total of 9 studies explored the relationship between pretreatment anemia and the OS of patients with STS. [14,21,22,24,[26][27][28][29]41] The pooled data shows that pre-treatment anemia is related to a poor OS (HR: 2.13, 95%CI: 1.52-2.98, P < .00001). A random-effect model was used due to the discovery of significant heterogeneity (I 2 = 75.9%; Fig.…”

“…Wang et al [14] 2016 USA 54 Mixed Mixed 10 OS Iqbal et al [27] 2016 India 110 Mixed Metastatic 10 OS/DFS Panotopoulos et al [21] 2015 Austria 85 Surgery Mixed 13.1 OS/DSS Szkandera et al [22] 2014 Austria 367 Surgery Nonmetastatic 13/12 * OS/DSS Kasper et al [29] 2013 Multi-country 343 Drug Metastatic NA OS/DFS Willegger et al [24] 2017 Austria 132 Surgery Mixed NA OS/DSS/DFS Stefanovski et al [28] 2012 Italy 376 Mixed Mixed 10 OS Nakamura et al [23] 2017 UK 376 Surgery Nonmetastatic 13/12 * DSS Nakamura et al [20] 2017 Japan 47 Mixed Metastatic 13/12 * DSS Maretty-Kongstad et al [25] 2017 Denmark 403 Mixed Nonmetastatic NA DSS de Nonneville et al [26] 2019 France 72 Drug Metastatic 12 OS/DFS Mahyudin et al [41] 2020 Indonesia 80 Surgery Nonmetastatic NA OS DFS = disease-free survival, DSS = disease-specific survival, NA = not available, OS = overall survival. * 13 mg/L in male and 12 mg/L in female.…”

An atypical lipomatous tumor of the hypopharynx, a unique entity? A rare case report

“…Furthermore, adjuvant chemoradiotherapy was added following the surgery. It based on the recurrence rate will be lower if the surgical margin is free from the tumor [17] . Around 80 % of cases of incomplete tumor excision were associated with an increased risk of local recurrence.…”

Karakteristik Soft Tissue Tumor Ekstremitas Berdasarkan Time Intensity Curve Pada Dynamic Contrast Enhancement - Mri

“…Meskipun dengan rasio rendah, angka kejadian di Amerika pada tahun 2019, kurang lebih mencapai 13.000 orang (Roland, 2020). Menurut data dari rumah sakit rujukan nasional kanker di Indonesia, menyatakan sarkoma jaringan lunak masuk dalam sepuluh jenis kanker paling sering di tahun 2013 dan sekitar 75% terjadi pada regio ekstremitas (Mahyudin dkk, 2020). Pada CT Scan massa menunjukkan kepadatan yang sama dengan otot dan kurang memberikan informasi yang spesifik.…”