Analysis of Postoperative Pain After Extraction of Impacted Mandibular Third Molars and Administration of Preemptive Analgesia

Neychev, Deyan; Chenchev, Ivan; Simitchiev, Kiril

doi:10.5272/jimab.2017233.1697

Cited by 5 publications

(8 citation statements)

References 12 publications

(8 reference statements)

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“…Preemptive analgesia is a controversial topic. Differences between experimental models, including different routes of administration, drug combinations, time of postoperative pain evaluation, types of surgery, [19]. There are numerous techniques for analgesic treatment of postoperative pain, but the interest in recent years has been focused on the preemptive analgesia.…”

Section: Resultsmentioning

confidence: 99%

Knowledge and Awareness on the Usage of Preemptive Analgesics in Third Molar Extraction among Dental Students: A Survey

Balaji

Prabu

2020

JPRI

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Postoperative pain control after extraction of third molars is important for patients because of the effect of pain symptoms on the healing process and quality of life. The aim of this study was to assess the knowledge and awareness of dental students towards the use of preemptive analgesics in third molar extractions. A questionnaire based survey was conducted among 100 dental students. Questionnaire was distributed through a survey link. Results were collected and analysed using IBM SPSS Statistical Analyzer (23.0 version). Frequency distribution and descriptive analysis were carried out. The variables were analysed using Pearson Chi square test. P Value less than or equal to 0.05 was considered to be statistically significant. The results of the study showed that the knowledge and awareness of dental students about the usage of preemptive analgesics in day to day practice varied according to their year of study. Interns were observed to have more knowledge and awareness regarding preemptive analgesics in comparison to third years and final years. Preemptive analgesics play a significant role in the elimination of postoperative pain in patients after removal of third molars. Therefore, it is of utmost importance for dental students to gain sufficient knowledge regarding the usage and importance of preemptive analgesics in dentistry.

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Section: Resultsmentioning

confidence: 99%

Knowledge and Awareness on the Usage of Preemptive Analgesics in Third Molar Extraction among Dental Students: A Survey

Balaji

Prabu

2020

JPRI

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“…Prevention and management of these processes is an important objective in dentistry. According to literature, a scientifically justified drug for controlling pain and inflammation is nimesulide, which is due to its high clinical effectiveness, safety profile and short onset of action [ 25 , 26 , 27 , 28 ]. According to the results of our survey, dentists most frequently use nimesulide to manage inflammation following dental interventions.…”

Section: Discussionmentioning

confidence: 99%

“…Like the quantitative optical microscopy we used in this work, laser diffraction analysis is a direct method of studying the size distribution of nimesulide API particles. But this method requires expensive specialized equipment [ 25 ], highly qualified and specially trained personnel, complex preparation for the final analytical process of the test, so it is not rapid and easy to perform. Based on this, in our opinion, laser diffraction analysis will be difficult to use as a "generally accessible" method of pilot detection of abnormal lots of generic drugs nimesulide on the market, in contrast to the proposed method of pharmacopoeial quantitative optical microscopy.…”

Section: Discussionmentioning

confidence: 99%

A survey and optical microscopy in pilot comparative analysis of generic and original nimesulide granules

Leonenko

Ostanina

Kokoieva

et al. 2021

Heliyon

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Background: Secondary to increased development of generic nonsteroidal anti-inflammatory drugs (NSAIDs), there is a lack of simple and inexpensive ways of pilot detection of differences between the batches of generic drugs and the original ones. Objectives: To determine the peculiarities of the use of generic NSAIDs in routine practice through a pilot survey of dentists and to conduct a pilot comparative analysis of generic and original NSAIDs containing nimesulide granules using optical microscopy. Methods: The first part of the study included a pilot survey Convenience sampling of 192 dentists to study the use of generic NSAIDs in their routine practice. The second part included the use of a pilot optical microscopy of nimesulide particles isolated from four drugs: original drug (NA) and generic ones (NB, NC, ND). Results: In the questionnaires, dentists pointed to a 68.7% lower clinical efficacy and a 62.6% higher percentage of side effects of generic NSAIDs compared to the original ones. Based on the results of pilot optical microscopy, a statically significant difference in the size distribution of the drug substance particles in all generic nimesulide granules was determined as follows: NB (χ 2 : 15.15; p < 0.01); NC (χ 2 : 11.09; p < 0.05); ND (χ 2 : 1625.34; p < 0.001) compared with the original drug NA. Conclusions: A pilot survey of dentists showed that doctors noted the practical difference in the effects of the original and generic NSAIDs. A significant difference in the size of nimesulide particles and their distribution in generic drugs NB, NC, ND compared to the original NA suggests a possible difference in bioavailability and bioequivalence.

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“…The pain assessment was carried out 6 hours post-dental extraction and every 12 h thereafter on the same day of extraction and the following two days, because the highest pain point is between 6 to 8 h after extraction and intensity of pain has been shown to reach its maximum in the first 24 h [5,6]. The pain assessment was recorded by the patient via a questionnaire (data collecting sheet) using the Visual Analogue Scale (VAS).…”

Section: Assessment Of Post-operative Dental Painmentioning

confidence: 99%

“…A recent study indicated that the intensity of pain reaches its maximum score in the first 24 h after surgical tooth extraction using the McGill Pain Questionnaire [5]. The highest pain point occurs between 6 and 8 h after extraction with conventional local anesthetic techniques, as a result of trauma to the hard and soft tissues caused by surgical dental extraction.…”

Section: Introductionmentioning

confidence: 99%

Loxoprofen Sodium Versus Diclofenac Potassium for Post-Dental Extraction Pain Relief: A Randomized, Triple-Blind, Clinical Trial

et al. 2019

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One of the most common post-operative complications of tooth extraction is pain. Oral analgesics, namely loxoprofen sodium and diclofenac potassium, are often prescribed; however, the efficacy of these drugs irrespective of gender and type of extraction has not been tested. Therefore, this study aimed to compare the efficacy of these two drugs in post-dental extraction pain relief among male and female patients in cases of simple and surgical tooth extraction. A single-center, triple-blind, randomized clinical trial was conducted among 100 male and female patients who underwent tooth extraction at Taibah University Dental College and Hospital in Al-Madinah, Saudi Arabia. The patients reported their pain post-operatively after 6 hours and every 12 h for 3 days using the Verbal Descriptor Scale (e.g., “no pain”, “mild pain”). Descriptive statistics and chi-square tests were run to analyze the data. An equal number of patients received either the drug loxoprofen sodium or diclofenac potassium and completed the study follow-up. Patients allocated to the diclofenac potassium drug group after 36 h were statistically significantly in their reporting of “no pain” and “mild pain” compared to patients allocated to the loxoprofen sodium group (86% vs. 66%, respectively; p = 0.019), irrespective of gender or type of tooth extraction. However, both groups demonstrated comparable (p > 0.05) post-operative pain relief over the other aforementioned allocated time intervals. In conclusion, the diclofenac potassium group had slightly better control over post-operative pain than the group receiving loxoprofen sodium.

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Analysis of Postoperative Pain After Extraction of Impacted Mandibular Third Molars and Administration of Preemptive Analgesia

Cited by 5 publications

References 12 publications

Knowledge and Awareness on the Usage of Preemptive Analgesics in Third Molar Extraction among Dental Students: A Survey

Knowledge and Awareness on the Usage of Preemptive Analgesics in Third Molar Extraction among Dental Students: A Survey

A survey and optical microscopy in pilot comparative analysis of generic and original nimesulide granules

Loxoprofen Sodium Versus Diclofenac Potassium for Post-Dental Extraction Pain Relief: A Randomized, Triple-Blind, Clinical Trial

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