Analysis of permeation profiles of drugs from systems containing micelles.

Juni, Kazuhiko; Tomitsuka, Toshiaki; Nakano, Masahiro; Arita, Takaichi

doi:10.1248/cpb.26.837

Cited by 8 publications

(3 citation statements)

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“…The eŠects of complexation, 29) micellar solubilization, 30,31) emulsion and cosolvent systems 32) on release rate through synthetic membranes were examined.…”

Section: Examination Of Biodegradable Polymers For Sustained Drug Relmentioning

confidence: 99%

From Physical Pharmacy to Clinical Pharmacology

Nakano

2005

YAKUGAKU ZASSHI

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Research works on molecular interactions in solutions were carried out at School of Pharmacy, the University of Wisconsin under the direction of Prof. T. Higuchi and at Faculty of Pharmaceutical Sciences, Kyoto University under the direction of Prof. H. Sezaki. Studies on permeation of drugs through polymer membranes were carried out at Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Canada and at Pharmaceutical Chemistry Research Laboratories at Food and Drug Directorate, Department of Health and Welfare, Canada. Studies on modiˆcation of delivery patterns by means of pharmaceutical approaches were carried out at Faculty of Pharmaceutical Sciences, Hokkaido University. Topics related to modiˆcation of drug delivery patterns include employment of amorphous forms such as ground mixture with micro-crystalline cellulose and coprecipitate with polyvinylpyrrolidone, use of biodegradable polymers such as polylactic acid and polycarbonates, gel-forming materials such as konjac, agar and hydroxypropylcellulose, and physicochemical systems such as complexation. Works related to drug delivery and disposition of drugs in humans were carried out at Department of Pharmacy, Kumamoto University Hospital. Topics related to drug delivery in humans include injections containing anticancer drugs for intra-arterial administration, lidocaine gels for dermal anesthesia, glucagon solution for nasal administration. Topics related to disposition of drugs in humans include clinical pharmacokinetic studies in infants and elderly and medical uses of adsorbents.

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“…The eŠects of complexation, 29) micellar solubilization, 30,31) emulsion and cosolvent systems 32) on release rate through synthetic membranes were examined.…”

Section: Examination Of Biodegradable Polymers For Sustained Drug Relmentioning

confidence: 99%

From Physical Pharmacy to Clinical Pharmacology

Nakano

2005

YAKUGAKU ZASSHI

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“…The transport of surfactants through porous polymeric materials is important in the treatment of wastewater containing detergents by membrane separation processes, the chemical modification of fabrics and leather by dyeing and tanning operations, , and the controlled release of surface-active drugs or chemical agents through polymeric membranes. − Surfactants have also been used in the controlled release of poorly water-soluble bioactive or chemical solutes across polymeric membranes by using micelles to increase the reservoir capacity of the solute. − The poorly water-soluble solute was dissolved at a high concentration, relative to the pure water phase, within the micelles of an aqueous surfactant solution. In those studies, the polymeric membranes were either solid, so that no micelle could diffuse across, or the membranes contained pores that were smaller than the micelle so that micelle transport could not occur either.…”

Section: Introductionmentioning

confidence: 99%

“…[4][5][6][7][8] Surfactants have also been used in the controlled release of poorly water-soluble bioactive or chemical solutes across polymeric membranes by using micelles to increase the reservoir capacity of the solute. [9][10][11] The poorly water-soluble solute was dissolved at a high concentration, relative to the pure water phase, within the micelles of an aqueous surfactant solution. In those studies, the polymeric membranes were either solid, so that no micelle could diffuse across, or the membranes contained pores that were smaller than the micelle so that micelle transport could not occur either.…”

Section: Introductionmentioning

confidence: 99%

Micelle-Mediated Transport of a Sparingly Soluble Drug through Nanoporous Membranes

Bhown¹,

Stroeve

2006

Ind. Eng. Chem. Res.

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Micelle-mediated solute transport through nanoporous membranes can considerably increase total solute transport compared to free diffusion of solute alone. Micelle-mediated solute transport is of importance in chemical modification of porous media and controlled-release applications when the solute is sparingly soluble in water. Experimental and theoretical results are given for the transport of a local anesthetic, n-butyl-paminobenzoate, dissolved in a micellar solution of iso-octylphenoxypolyethoxyethanol through nanoporous polypropylene membranes. The membranes have slit-like pores with a characteristic dimension of 40 nm. The theory, based on the phase-separation model, is in good agreement with the experimental results on micelle-mediated transport of the anesthetic through the nanoporous membranes. Hindered diffusion of micelles inside the slit-like pores is taken into account in the theory since the micelles are spherical with a diameter of 9.28 nm.

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A theoretical analysis of micelle-mediated transport through porous membranes

Krovvidi

Stroeve

1986

Journal of Colloid and Interface Science

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Analysis of permeation profiles of drugs from systems containing micelles.

Cited by 8 publications

References 0 publications

From Physical Pharmacy to Clinical Pharmacology

From Physical Pharmacy to Clinical Pharmacology

Micelle-Mediated Transport of a Sparingly Soluble Drug through Nanoporous Membranes

A theoretical analysis of micelle-mediated transport through porous membranes

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