A theoretical analysis of micelle-mediated transport through porous membranes

Krovvidi, K.R.; Stroeve, Pieter

doi:10.1016/0021-9797(86)90396-6

Cited by 6 publications

(7 citation statements)

References 21 publications

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“…However, the diffusion cjf associating solutes is more frequently described by using pseudobinary transport equations (8,(21)(22)(23)(24)(25)(26)(27)(28)(29) Can. J. Chem.…”

Section: Discussionmentioning

confidence: 99%

Coupled diffusion of butanol solubilized in aqueous sodium dodecylsulfate micelles

Leaist¹

1990

Can. J. Chem.

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DEREK G. LEAIST. Can. J. Chem. 68, 33 (1990).Ternary interdiffusion coefficients have been measured for ten compositions of the system sodium dodecylsulfate (NaDS) + 1-butanol (BuOH) + water at 25OC. The diffusivity of BuOH in this system is lower than in pure water because about one half of the alcohol is solubilized in the slowly-diffusing NaDS micelles. Yet, surprisingly, diffusion of the NaDS component transports only minor amounts of BuOH. Diffusion of the BuOH component, however, produces a substantial coupled flow of NaDS. Although added BuOH increases the solution viscosity and the size of the micelles, the diffusivity of the NaDS component does not change significantly. The Harned restricted diffusion method for the determination of electrolyte diffusivities is extended to electrolyte + nonelectrolyte solutes.

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“…However, the diffusion cjf associating solutes is more frequently described by using pseudobinary transport equations (8,(21)(22)(23)(24)(25)(26)(27)(28)(29) Can. J. Chem.…”

Section: Discussionmentioning

confidence: 99%

Coupled diffusion of butanol solubilized in aqueous sodium dodecylsulfate micelles

Leaist¹

1990

Can. J. Chem.

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“…As shown by Krovvidi and Stroeve 27 for a surfactant−drug system, larger values of the equilibrium distribution coefficient are often associated with larger micelles, which implies that the micellar pore permeability may be smaller. However, the relationship between κ and P M may be complex with κ being more sensitive to micelle size than P M . , In general, for the approximations considered here, eqs 16−18 show that the contribution of micelle-mediated drug transport increases as the product of P M κ C increases relative to the pore permeability of the drug, P D .…”

Section: Discussionmentioning

confidence: 92%

“…Equation 2 assumes that the spherical molecule diffuses along the axis of the pore. In our case of drug diffusion, the radius of the drug (∼0.4 nm) is much smaller than the half width of the pore (∼16.5 nm, after surfactant adsorption) and, therefore, the pore diffusivity is nearly equal to the free diffusivity …”

Section: Theorymentioning

confidence: 88%

“…In our case of drug diffusion, the radius of the drug (∼0.4 nm) is much smaller than the half width of the pore (∼16.5 nm, after surfactant adsorption) and, therefore, the pore diffusivity is nearly equal to the free diffusivity. 27 The pore diffusivity is based on the concentration of solute in the pore. The solute concentration in the pore can be related to the bulk concentration by assuming thermodynamic equilibrium between the bulk and the pore mouth.…”

Section: Theorymentioning

confidence: 99%

“…Nanoporous membranes are of current interest for the selective transport of species. − Micelle-mediated solute transport through nanoporous polymeric membranes can occur if the pores in the membranes are larger than the micelles. − The diffusion of micelles encapsulating another species, a “solubilizate”, through the pores of the membrane can considerably increase the transport compared to the transport obtained from purely Fickian diffusion of the solubilizate alone. Micelle-mediated transport of drugs through nanoporous membranes is of interest in controlled-release applications. ,− …”

Section: Introductionmentioning

confidence: 99%

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Micelle-Mediated Transport of a Sparingly Soluble Drug through Nanoporous Membranes

Bhown¹,

Stroeve

2006

Ind. Eng. Chem. Res.

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Micelle-mediated solute transport through nanoporous membranes can considerably increase total solute transport compared to free diffusion of solute alone. Micelle-mediated solute transport is of importance in chemical modification of porous media and controlled-release applications when the solute is sparingly soluble in water. Experimental and theoretical results are given for the transport of a local anesthetic, n-butyl-paminobenzoate, dissolved in a micellar solution of iso-octylphenoxypolyethoxyethanol through nanoporous polypropylene membranes. The membranes have slit-like pores with a characteristic dimension of 40 nm. The theory, based on the phase-separation model, is in good agreement with the experimental results on micelle-mediated transport of the anesthetic through the nanoporous membranes. Hindered diffusion of micelles inside the slit-like pores is taken into account in the theory since the micelles are spherical with a diameter of 9.28 nm.

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