With rapid changes in climate and the seasonal amplitude of carbon dioxide (CO 2 ) in the Arctic, it is critical that we detect and quantify the underlying processes controlling the changing amplitude of CO 2 to better predict carbon cycle feedbacks in the Arctic climate system. We use satellite and airborne observations of atmospheric CO 2 with climatically forced CO 2 flux simulations to assess the detectability of Alaskan carbon cycle signals as future warming evolves. We find that current satellite remote sensing technologies can detect changing uptake accurately during the growing season but lack sufficient cold season coverage and near-surface sensitivity to constrain annual carbon balance changes at regional scale. Airborne strategies that target regular vertical profile measurements within continental interiors are more sensitive to regional flux deeper into the cold season but currently lack sufficient spatial coverage throughout the entire cold season. Thus, the current CO 2 observing network is unlikely to detect potentially large CO 2 sources associated with deep permafrost thaw and cold season respiration expected over the next 50 y. Although continuity of current observations is vital, strategies and technologies focused on cold season measurements (active remote sensing, aircraft, and tall towers) and systematic sampling of vertical profiles across continental interiors over the full annual cycle are required to detect the onset of carbon release from thawing permafrost.carbon cycle | permafrost thaw | climate | Earth system models | remote sensing T he future trajectory of carbon balance in the Arctic-Boreal Zone (ABZ) is of global importance because of the vast quantities of carbon sequestered in permafrost soils (1). Climate warming threatens to increase permafrost thaw and release soil carbon back to the atmosphere as a positive feedback promoting additional warming (2). It is unclear whether the observed intensification of the northern high-latitude carbon cycle is dominated by plant productivity or microbial decomposition, both of which seem to be increasing (3-6). Although warming temperatures and C/N fertilization promote greening and higher summer productivity during the short, intense growing season, these same factors also drive increased emissions during the long cold season (3-5).Detecting changes in ABZ carbon balance requires sustained observations over the full annual cycle. In the last decade, researchers have recognized the importance of year-round landatmosphere CO 2 flux observations (3-5). Synthesis studies of these data show that increasing growing season uptake has been offset by stronger winter respiration. Measurements of atmospheric CO 2 collected from in situ and remote sensing instruments provide spatially and temporally integrated constraints of net CO 2 exchange on regional to pan-Arctic scales. In situ observations have been limited primarily to a small network of surface towers and infrequent, short duration airborne campaigns designed primarily to detect the pan-Ar...