Analysis of Normal Retinal Nerve Fiber Layer Thickness by Age, Sex, and Race Using Spectral Domain Optical Coherence Tomography

Alasil, Tarek; Wang, Kaidi; Keane, Pearse A.; Lee, Hang; Baniasadi, Neda; Boer, Johannes F. de; Chen, Teresa C.

doi:10.1097/ijg.0b013e318255bb4a

Cited by 239 publications

(205 citation statements)

References 16 publications

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“…In the present research, a statistically meaningful negative correlation was demonstrated between the global mean peripapillary RNFL thickness and age, which has been reported before in various studies (15,16). Yet no significant difference was observed between the two age groups and two sex groups in the present study, which suggested that age and sex may not affect macular retinal thickness and RNFL thickness.…”

Section: Comparisons Between Se Groups (P-value) --------------------supporting

confidence: 67%

“…From the present results, it may be proposed that the global RNFL thickness has a linear increase with the increase of SE. This trend may explain why the average global RNFL thickness in the present study (100.08 µm) was thinner than 102 µm obtained in a study by Zhao et al (15), but close to 100.7 µm obtained in a study by Alasil et al (16). All three studies were concerned with Asian individuals.…”

Section: Discussioncontrasting

confidence: 39%

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Evaluation of myopia on retinal nerve fiber layer thickness measured by Spectralis optical coherence tomography

Zha

Zhuang

Lin

et al. 2017

Experimental and Therapeutic Medicine

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Abstract. The aim of the present study was to evaluate the retinal nerve fiber layer (RNFL) thickness of myopic subjects using Spectralis optical coherence tomography (OCT) and to determine variations with age and sex. A total of 271 Chinese participants with a spherical equivalent <+0.50 diopters were enrolled in the research. All subjects underwent a full ophthalmic examination. RNFL thickness was measured and compared according to sex, age and spherical equivalent. No significant difference was demonstrated between RNFL thickness in males and females. No significant difference was observed between RNFL thickness of the two age groups (≤12 years old and >12 years old). Significant differences were observed in all subfields of RNFL thickness among different spherical equivalent groups (P<0.05). In conclusion, myopia did have special influence on RNFL thickness, which was not related to sex or age.

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Section: Comparisons Between Se Groups (P-value) --------------------supporting

confidence: 67%

Section: Discussioncontrasting

confidence: 39%

Evaluation of myopia on retinal nerve fiber layer thickness measured by Spectralis optical coherence tomography

Zha

Zhuang

Lin

et al. 2017

Experimental and Therapeutic Medicine

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“…Refractive error and age at examination are some of the well-known confounding factors in the interpretation of peripapillary RNFL thickness. [32][33][34][35][36][37][38] In addition, we performed correlation analysis between various baseline factors and peripapillary RNFL thicknesses in multiple sectors separately. As there was a difference in the pattern of RNFL distribution according to different sectors, it would be more accurate to analyze RNFL thickness in each sector separately.…”

Section: Variablementioning

confidence: 99%

Retinal nerve fiber layer thickness in prematurity is correlated with stage of retinopathy of prematurity

2015

Eye

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Purpose To compare retinal nerve fiber layer (RNFL) thickness profiles between preterm and full-term children and to investigate factors affecting the RNFL distribution in preterm children.Methods We performed Spectral domain optical coherence tomography (SD-OCT) peripapillary RNFL circular scan centered on the optic disc in 50 premature and 58 full-term children. RNFL thickness profiles were compared between preterm and fullterm children using a linear regression model. Among preterm patients in this study, 20 patients previously received laser treatment for severe retinopathy of prematurity (ROP).Results Global average, nasal, and superior disc RNFL thickness profiles were significantly smaller in preterm children (92.70 ± 16.57 μm, 56.02 ± 17.04 μm, and 108.74 ± 27.36 μm, respectively) compared with full-term children (101.63 ± 9.21 μm, P = 0.006, 69.14 ± 14.15 μm, Po0.001, and superior, 129.11 ± 18.14 μm, Po0.001, respectively). Multivariable analysis revealed that ROP stage was inversely correlated with nasal RNFL thickness (P = 0.010).Conclusions Our SD-OCT data demonstrate decreased global average, nasal, and superior disc RNFL thicknesses in preterm children. ROP stage was inversely correlated with nasal RNFL thickness. Further studies are needed to better understand the association between these structural changes and visual functions in preterm children.

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“…The control participants were race, age and gender matched to the participants with keratoconus. Study participants were aged between 18 years and 33 years to minimise the effect of age on RNFL thickness, as previous studies 30, 31 have reported a decrease in RNFL thickness with increasing age.…”

Section: Methodsmentioning

confidence: 99%

Retinal nerve fibre layer and ganglion cell complex thickness in patients with keratoconus

Cuppusamy

Makhanya

Methula

et al. 2018

Afr. vis. eye health

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Background: Keratoconus, a corneal ectasia, is associated with corneal thinning and altered optical media. Consequently, assessment of the visual field, optic nerve head and intraocular pressure measurements may be challenging in patients with keratoconus. Few studies have investigated posterior segment variables including the retinal nerve fibre layer (RNFL) and ganglion cell complex (GCC) thickness in patients with keratoconus.Aim: To investigate RNFL and GCC thickness in patients with keratoconus.Methods: A comparative quantitative research design was used. The sample consisted of 56 participants (28 with mild, moderate or severe keratoconus, and 28 controls) who accessed the optometry clinic at the University of KwaZulu-Natal. There was an equal distribution of male (n = 14) and female (n = 14) participants in the keratoconus and control groups. Most participants were black (n = 34) or Indian (n = 18). Corneal power and refractive error were assessed with the Oculus Keratograph and subjective refraction respectively. The iVue-100 optical coherence topography device was used to measure RNFL and GCC thickness. Data were analysed by descriptive and inferential statistics.Results: The mean global RNFL thickness was slightly higher in the control group than the keratoconus group for the right (106 µm vs. 99 µm) and left (103 µm vs. 98 µm) eyes but these differences were not significant (p ≥ 0.057). For all RNFL quadrants, slightly lower mean RNFL measurements were found in the keratoconus group. The mean GCC thicknesses were marginally higher (3 µm – 6 µm) in the control group.Conclusion: The RNFL and GCC thickness differences between patients with keratoconus and controls are not clinically significant. Therefore, abnormally reduced RNFL and GCC thickness measurements in patients with keratoconus warrant further investigation for other pathologies specifically glaucoma.

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Analysis of Normal Retinal Nerve Fiber Layer Thickness by Age, Sex, and Race Using Spectral Domain Optical Coherence Tomography

Cited by 239 publications

References 16 publications

Evaluation of myopia on retinal nerve fiber layer thickness measured by Spectralis optical coherence tomography

Evaluation of myopia on retinal nerve fiber layer thickness measured by Spectralis optical coherence tomography

Retinal nerve fiber layer thickness in prematurity is correlated with stage of retinopathy of prematurity

Retinal nerve fibre layer and ganglion cell complex thickness in patients with keratoconus

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