Analysis of neutral isomeric low molecular weight carbohydrates using ferrocenyl boronate derivatization and tandem electrospray mass spectrometry

Williams, Dudley; Young, Mary K.

doi:10.1002/1097-0231(20001130)14:22<2083::aid-rcm136>3.0.co;2-w

Cited by 31 publications

(20 citation statements)

References 36 publications

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“…5 (1) [24].™ After normalizing, these values are converted to the calculated™ percentages™ by™ dividing™ each™ value™ by™ the™ sum™ of the two values. Thus, the molar percent of T3 and rT3 in the mixture is obtained.…”

Section: Quantification Of T3 and Rt3mentioning

confidence: 99%

Detection and quantification of 3,5,3′-triiodothyronine and 3,3′,5′-triiodothyronine by electrospray ionization tandem mass spectrometry

Zhang

Conrad

2005

J. Am. Soc. Mass Spectrom.

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A novel and rapid method for identifying and quantifying 3,5,3=-triiodothyronine (T3) and 3,3=,5=-triiodothyronine (rT3; reverse T3) has been introduced using electrospray ionization tandem mass spectrometry (ESI-MS/MS). MS 2 spectra in either negative ionization mode or positive ionization mode can be used to differentiate T3 and rT3. Quantification of the T3 and rT3 isomers under the negative ionization mode is also achieved without prior separation by HPLC. (J Am Soc Mass Spectrom 2005, 16, 1781-1786

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Section: Quantification Of T3 and Rt3mentioning

confidence: 99%

Detection and quantification of 3,5,3′-triiodothyronine and 3,3′,5′-triiodothyronine by electrospray ionization tandem mass spectrometry

Zhang

Conrad

2005

J. Am. Soc. Mass Spectrom.

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“…The derivatives were applied to a complex carbohydrate mixture from honey [107]. Ferrocenyl boronates (6) of N-acetylaminohexoses have been differentiated by mass spectral fragmentation after they were formed within the spray of an electrospray instrument [108] and differentiation of isomeric monoand -disaccharides has been achieved by the same technique [109]. It was believed that both five-and six-membered rings were formed.…”

Section: Cyclic Alkane Boronatesmentioning

confidence: 99%

Derivatization of carbohydrates for analysis by chromatography; electrophoresis and mass spectrometry

Harvey¹

2011

Journal of Chromatography B

217

156

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“…The applicability of the method was demonstrated for different compound classes like metal complexes, metal porphyrins, fullerenes, and other compounds that form stable organic radicals. Neutral mono-and disaccharides could be oxidized as their cyclic ferrocenyl boronic esters and analyzed by MS-MS and MS-MS-MS [48]. Ferrocenecarboxylic acids [49] were used for derivatization and even alkenes could be ionized with electrochemical oxidation by derivatization with an electroactive group like ferrocene boronic acid [50,51].…”

Section: Electrochemistrymentioning

confidence: 99%

LC-MS analysis in the aquatic environment and in water treatment ? a critical review

Zwiener

Frimmel

2004

Analytical and Bioanalytical Chemistry

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LC-MS has become an invaluable technique for trace analysis of polar compounds in aqueous samples of the environment and in water treatment. LC-MS is of particular importance due to the impetus it has provided for research into the occurrence and fate of polar contaminants, and of their even more polar transformation products. Mass spectrometric detection and identification is most widely used in combination with sample preconcentration, chromatographic separation and atmospheric pressure ionization (API). The focus of the first part of this review is directed particularly toward instruments and method development with respect to their applications for detecting emerging contaminants, microorganisms and humic substances (HS). The current status and future perspectives of 1) mass analyzers, 2) ionization techniques to interface liquid chromatography (LC) with mass spectrometry (MS), 3) methods for preconcentration and separation with respect to their application for water analysis are discussed and examples of applications are given. Quadrupole and ion trap mass analyzers with electrospray ionization (ESI) and atmospheric pressure chemical ionization (APCI) are already applied in routine analysis. Time-of-flight (TOF) mass spectrometers are of particular interest for accurate mass measurements for identification of unknowns. For non-polar compounds, different ionization approaches have been described, such as atmospheric pressure photoionization (APPI), electrochemistry with ESI, or electron capture ionization with APCI. In sample preconcentration and separation, solid phase extraction (SPE) with different non-selective sorbent materials and HPLC on reversed-phase materials (RP-HPLC) play the dominant role. In addition, various on-line and miniaturized approaches for sample extraction and sample introduction into the MS have been used. Ion chromatography (IC), size-exclusion chromatography (SEC), and capillary electrophoresis (CE) are alternative separation techniques. Furthermore, the issues of compound identification, matrix effects on quantitation, development of mass spectral libraries and the topic of connecting analysis and toxicity bioassays are addressed.

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Analysis of neutral isomeric low molecular weight carbohydrates using ferrocenyl boronate derivatization and tandem electrospray mass spectrometry

Cited by 31 publications

References 36 publications

Detection and quantification of 3,5,3′-triiodothyronine and 3,3′,5′-triiodothyronine by electrospray ionization tandem mass spectrometry

Detection and quantification of 3,5,3′-triiodothyronine and 3,3′,5′-triiodothyronine by electrospray ionization tandem mass spectrometry

Derivatization of carbohydrates for analysis by chromatography; electrophoresis and mass spectrometry

LC-MS analysis in the aquatic environment and in water treatment ? a critical review

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